Epizyme Powder for Dogs & Cats, 12-oz

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$136.55 First Time Autoship Price
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$156.55 Chewy Price
($13.05 /oz)
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Medications ship separately. Delivery times may vary.

About This Item

Details

Epizyme is a prescription powder that acts as a digestive aid. This medication is most commonly used in those who are not able to properly digest food due to the lack of digestive enzymes created by the pancreasa condition known as exocrine pancreatic insufficiency (EPI). Epizyme helps to improve the digestion of proteins, carbohydrates and fats, while also helping your pet get to a healthy weight.

We directly source prescription medications from manufacturers and wholesale distributors registered with the FDA and licensed by applicable state boards. Guaranteed genuine, and where applicable, backed by the manufacturer.

Ingredients

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FAQ

Learn More About Epizyme From Our Team of Experts

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4.5
Rated 4.5 out of 5 stars
259 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

82% Positive

Effectiveness

81% Positive

Ingredients

80% Positive

Long-Term Benefits

81% Positive

113 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Tracy on Jan 28, 2026

Processed the order quickly

My dog needs to take these enzymes every day, so I liked the autoship reminder and the options of day sent and frequency and the quickness of filling the order.

My dog needs to take these enzymes every day, so I liked the autoship reminder and the options of day sent and frequency and the quickness of filling the order.

Rated 5 out of 5 stars
By Glenda on Oct 7, 2025

Convience

The medication is helping our fur baby live her best life, our little rescue is a pure joy. She is doing better in the Epixyme then the other pancrease med from

The medication is helping our fur baby live her best life, our little rescue is a pure joy. She is doing better in the Epixyme then the other pancrease med from the vet and at a lower cost.

Rated 5 out of 5 stars
By Cathi on Nov 5, 2025

Abby has EPI

Abby needs this to stay alive. So thankful Chewy could get it to us so quickly. Abby is doing fine with the powder.

Abby needs this to stay alive. So thankful Chewy could get it to us so quickly. Abby is doing fine with the powder.

Rated 2 out of 5 stars
By Karon on Aug 17, 2025

saw slow improvements at first but EPI dog won't eat now

literature reco'd powder and very slowly improvements started after three days. However, now, less than a week in, GSD 2 yr old refused to eat the food. Have now

literature reco'd powder and very slowly improvements started after three days. However, now, less than a week in, GSD 2 yr old refused to eat the food. Have now ordered pancreplus tablets instead. Reviewers said dogs will eat the tabs readily. I will review tablets results once we have tried them.

Rated 5 out of 5 stars
By Georgia on Dec 2, 2025

IPE Treatment

Putting this enzyme on my dog’s food has really worked to control her IPE symptoms.

Putting this enzyme on my dog’s food has really worked to control her IPE symptoms.

Rated 5 out of 5 stars
By Tonua on Sep 16, 2025

Quality of the product

My dog was diagnosed with EPI. After a couple of weeks I could really tell a difference in her overall body. This product has made a difference in our Audrey’s

My dog was diagnosed with EPI. After a couple of weeks I could really tell a difference in her overall body. This product has made a difference in our Audrey’s health.

Rated 2 out of 5 stars
By Jacquie on Jul 1, 2025

Enzyme Powder

I initially tried the PancrePlus enzyme powder, which was working very well, but switched to the Epizyme because it is $50 cheaper. Unfortunately, the Epizyme

I initially tried the PancrePlus enzyme powder, which was working very well, but switched to the Epizyme because it is $50 cheaper. Unfortunately, the Epizyme enzyme powder is not working Rainey. The PancrePlus which we had only used for one month, pretty much had her back to normal. But after using this for a couple of weeks, she is actually reverting back to where we were after the diagnosis. Where this might work for some dogs, it is not working for her.

Rated 5 out of 5 stars
By Cindy on Jun 7, 2025

It worked great.

This was a good enzyme to help when the pancreas is not processing food. But you have to wait the 10-15 min for it to activate in the food before giving it to your

This was a good enzyme to help when the pancreas is not processing food. But you have to wait the 10-15 min for it to activate in the food before giving it to your pet. I wish I had know about this when my Macy had bad gas. It was the start to her pancreatic cancer and didn't start using this until she was diagnosed a year later. It's worked great and her poo wasn't perfect, but it wasn't diarreha which meant it was processing the food in her tummy. Also had to take out all hard kibble and feed only soft food. Soft food digested better.

Rated 5 out of 5 stars
By Sandra on Sep 25, 2025

Saves my puppy

My Molly has EPI. Her pancreas doesn't work. This powder goes on her can food and helps her pancreas work.

My Molly has EPI. Her pancreas doesn't work. This powder goes on her can food and helps her pancreas work.

Rated 5 out of 5 stars
By Susy on Nov 27, 2025

Chewy got this item to me quite quickly when I desperately needed it!

Weird product but it works well and I’m thrilled to have it!

Weird product but it works well and I’m thrilled to have it!