Equisul-SDT Oral Suspension for Horses, 400mg/mL, 560mL

Is Equisul-SDT� FDA approved? *Yes! It is approved for oral administration, BID * It is the only sulfonamide labeled for twice a day oral use in horses *Note: Human approved SMZ/TMP tabs and 2x day dosing of powder formulations are inappropriate extra label use according to AMDUCA law and all liability for adverse events falls on the prescriber

Is Equisul-SDT a liquid formulation of SMZ tabs? *No! Equisul-SDT�s formulation is different than SMZs * Equisul-SDT is an oral suspension of micronized trimethoprim particles in a solution of sulfadiazin

What makes Equisul-SDT unique? *Bioavailability. Equisul SDT obtains a steady state plasma concentration in excess of MIC 90 for Streptococcus equi subsp. zooepidemicus * It is formulated for optimum absorption by the horse�s GI tract

Is Equisul-SDT safe? *Yes! * It is the only oral sulfonamide antibiotic approved for use in horses that has undergone a modern safety study for approval

Why does Equisul-SDT have an increased bioavailability? A little about drug absorption: Drugs are absorbed into systemic circulation by going into solution. The speed at which this transition happens is highly controlled by two things: particle size and local pH.

• Equisul-SDT�s unique formulation controls its increased absorption
• The sulfadiazine component is already in solution made possible by controlling for pH
• The trimethoprim component is micronized particles which increase the surface area to volume ratio of the particles lending to rapid dissolution

Is Equisul-SDT more effective than other sulfa formulations? * Human approved SMZ/TMP tabs and competitor powder have reduced bioavailability for two main reasons: (1) feed inhibiting their absorption and (2) the poor ability of sulfas to go into solution while in the small intestine of horses * Only Equisul-SDT reaches consistent target plasma concentrations in fed or fasted horses * Equisul-SDT�s formulation ensures proper absorption in the small intestine

Can Equisul-SDT be used in foals? * Efficacy and safety studies performed for FDA approval were only done in adult horses * One pharmacokinetics study was done post-approval in neonatal foals by Dr. Swain-O�Fallon See reference: Swain O�Fallon, et. al., Journal of Veterinary Pharmacology and Therapeutics, 2020;00:1-8