K9 Advantix II Flea & Tick Spot Treatment for Dogs, 4-10 lbs, 6 Doses (6-mos. supply)

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About This Item

Details

  • Helps to protect small dogs weighing 4 to 10 pounds from fleas, ticks, mosquitoes, biting flies and lice.
  • Starts working within hours of application.
  • Kills and repels on contact, so fleas don’t have to bite your furbaby to die.
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours.
  • No prescription needed.

Ingredients

Instructions

Size

FAQ

Learn More About K9 Advantix II From Our Team of Experts
Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About K9 Advantix II

K9 Advantix II Fights 5 Major Pests

K9 Advantix II protects against fleas, ticks, mosquitoes, biting flies, and lice. It kills fleas on dogs within 12 hours and continues to prevent infestations for 4 weeks. Do not use on cats.

How K9 Advantix II Works

The active ingredients in K9 Advantix II (imidacloprid, permethrin, and pyriproxyfen) spread over the skin. Fleas and ticks are killed through contact, so they don’t have to bite your dog to die.

Flea Treatment & Prevention

K9 Advantix II kills and repels fleas, ticks, and mosquitoes.

Kills & Repels

These flea drops kill adult fleas, flea larvae, and flea eggs to break the flea lifecycle.

Same-Day Effectiveness

K9 Advantix II kills fleas on dogs within 12 hours, and it keeps working for four weeks to prevent reinfestation.

No Prescription Needed

You don’t have to go to the vet to get quality flea and tick protection for your dog—simply buy and apply.

Fragrance-Free

This flea topical formula is fragrance-free and waterproof 24 hours after application.

Frequently Asked Questions

Can I use K9 Advantix II on My Dog?

K9 Advantix II is for dogs 7 weeks of age and older. This product comes in four sizes: Small Dog (4-10 lbs.), Medium Dog (11-20 lbs.), Large Dog (21-55 lbs.), and Extra Large Dog (over 55 lbs.). Choose the right size based on your dog’s weight, and do not use on cats.

How Do I Apply K9 Advantix II?

Break the seal on the tube, then part the hair along the top of your dog’s back and evenly apply the contents from the shoulder down to the base of the tail. The number of application spots will depend on the size and weight of your dog—refer to the product label for detailed instructions.

The Advantage Family

Get the Advantage over fleas with complete flea protection for your pet, home, and yard. The Advantage family of products has everything you need for a complete flea treatment and prevention plan, including monthly topical treatments, pet shampoos and sprays, household sprays for carpets and crevices, and even a yard and premise spray. Just be sure to get the right product for each need and use only as directed.

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Questions & Answers

15 Customer Questions

Are there side effects from using Advantix for small dogs

Answer by Teresab • Apr 06, 2022
We haven’t experienced any! We hold our dog a few minutes until the drops have time to dry ( she tries to wipe it off in her dog bed)

does Advantix require a prescription from the vet?

Answer by Chewy • Jun 29, 2018
A prescription is not needed to purchase this flea and tick treatment.

I have two puppies toy poodle 6 and 7 pounds, do I have to keep the separate for 12 hours or any suggestions of what can I do, to be on the safe side. Like maybe keep them separate for 12 hours. Or wearing clothes after the 12 hours or after; what are your suggestions?

Answer by Chewy • Mar 24, 2021
Do not allow the dogs to lick any of the application sites and keep separated for 30 minutes.

Will this product work on sticktight fleas

Answer by Chewy • May 24, 2018
This Treatment works to kill and repel all fleas present on the dog including Sticktight Fleas.
Reviews
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4.4
Rated 4.4 out of 5 stars
1713 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

80% Positive

Effectiveness

79% Positive

Ingredients

75% Positive

Long-Term Benefits

79% Positive

811 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 3 out of 5 stars
By Tammy on Dec 8, 2025

My dog kept itching

My dog was good for several days and started itching again. It wasn’t as bad as it had been but it still didn’t get rid of the fleas completely. I get it’s not from

My dog was good for several days and started itching again. It wasn’t as bad as it had been but it still didn’t get rid of the fleas completely. I get it’s not from the vet but I used this product before and it worked really well. Maybe it just works differently on each dog. I’m going to stick with it and see if it gets better over the next few months. If not I will have to reevaluate.

Rated 3 out of 5 stars
By Jenny on Jan 24, 2026

Dosage

For 4-10 lbs the liquid inside the capsule sounded and extracted very little. I've ordered this before from other third party, and it was never this little.

For 4-10 lbs the liquid inside the capsule sounded and extracted very little. I've ordered this before from other third party, and it was never this little.

Rated 4 out of 5 stars
By vannah on Nov 1, 2025

Effective at flea control but

my dog unfortunately seems to be allergic to the active ingredients and has been moderately itchy at the application site for 2 days. Not the fault of the product

my dog unfortunately seems to be allergic to the active ingredients and has been moderately itchy at the application site for 2 days. Not the fault of the product and is a common side effect. We will have to try a different product

Rated 5 out of 5 stars
By Nancy on Nov 24, 2025

No more fleas

We recently moved across the state and noticed our old flea treatment system wasn’t working very well. Local vet recommended this product and it has taken cont

We recently moved across the state and noticed our old flea treatment system wasn’t working very well. Local vet recommended this product and it has taken control.

Rated 2 out of 5 stars
By Linda on Oct 19, 2025

The first tube I open was dry out

I open it and went put on mila and nothing came out I try open it wider and shook it bit was dried out. These are to expensive to lose even one dose im going look

I open it and went put on mila and nothing came out I try open it wider and shook it bit was dried out. These are to expensive to lose even one dose im going look at other options see if there something better for my pumpkin mila

Rated 1 out of 5 stars
By catherine on Oct 26, 2025

N/A

It was in auto delivery but nobody called me to verify if this product would work for me because it is got a 6 pound dog but my dog is now 14 pounds - needless to

It was in auto delivery but nobody called me to verify if this product would work for me because it is got a 6 pound dog but my dog is now 14 pounds - needless to say, it is not the right oroduct

Rated 5 out of 5 stars
By Renita on Jan 20, 2026

Ticks/Fleas

No fleas and only one tick and it was dead when removed. Great product!!!!!

No fleas and only one tick and it was dead when removed. Great product!!!!!

Rated 1 out of 5 stars
By Dawn on Jan 23, 2026

Cpupon not honored

I don't know why you didn't use my $15 off coupon for my order.

I don't know why you didn't use my $15 off coupon for my order.

Rated 1 out of 5 stars
By YorkieMom on Jul 30, 2025

Caused Scratching & Burning

Caused excessive burning and scratching to the point one dog hurt her back leg trying to keep scratching at the back of her neck. I only gave her about half a dose

Caused excessive burning and scratching to the point one dog hurt her back leg trying to keep scratching at the back of her neck. I only gave her about half a dose. She walked on 3 legs and had to be carried up and down the stairs for several days. I got a few drops on my skin by accident and had to put aloe on it for a few hours due to the burning of my skin. I gave them a bath approximately 18 hours later and they were still trying to scratch where I originally put it. Finally calmed down after several days.

Rated 4 out of 5 stars
By DaiSuki2U on Oct 18, 2025

Somewhat Effective

I hate using poison on my dogs period but this seems to be the most effective way. I had never had to deal with fleas on my dogs till I moved to Eastern Texas.

I hate using poison on my dogs period but this seems to be the most effective way. I had never had to deal with fleas on my dogs till I moved to Eastern Texas.