Lysodren (Mitotane) Tablets, 500-mg, 10 tablets

Have a Chewy account?
Sign in to quickly add pet health details.
$243.10 First Time Autoship Price
this order
Save 35% (up to $20) today when you set up Autoship. 

$249.94 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Never miss a dose with easy refills
  • Skip, change, or cancel anytime
$263.10 Chewy Price
($26.31 /ea)
Promo, Save 20% on first Rx order with code
Promo, Save 20% on first Rx order with code RX20

In Stock
FREE delivery
Usually arrives in 3-5 days
Prescription approval made easy
We’ll reach out to your vet clinic.

No interest if paid in full in 6 months. .

Medications ship separately. Delivery times may vary.

About This Item

Details

Lysodren is an oral tablet prescription medication used to help those who suffer from pituitary-dependent Cushing's disease. Plus, it can be used to treat some of the symptoms associated with adrenal gland tumors.We directly source prescription medications from manufacturers and wholesale distributors registered with the FDA and licensed by applicable state boards. Guaranteed genuine, and where applicable, backed by the manufacturer.

Ingredients

Instructions

FAQ

Learn More About Lysodren From Our Team of Experts
4.3
Rated 4.3 out of 5 stars
33 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

85% Positive

Effectiveness

83% Positive

Ingredients

90% Positive

Long-Term Benefits

81% Positive

13 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Bradley on Sep 8, 2025

Easy Ordering and Support

My dog was prescribed a new and rather expensive medication. I ordered what I thought the Vet wanted but got it wrong. The Chewy pharmacy was great, fixed the problem

My dog was prescribed a new and rather expensive medication. I ordered what I thought the Vet wanted but got it wrong. The Chewy pharmacy was great, fixed the problem and made it right. Then when I got a double order and double bill, that was also fixed quickly and the reimbursement was very prompt. Nothing but great service hence the 5 stars.


Rated 2 out of 5 stars
By David on Nov 30, 2024

Unreliable shipping

My order was a prescription drug that I needed urgently. The item was being delivered by Fed Ex and I was tracking the shipment. I was not at home at the time,

My order was a prescription drug that I needed urgently. The item was being delivered by Fed Ex and I was tracking the shipment. I was not at home at the time, so once the item status when to "out for delivery" I drove 170 miles to pick it up. While waiting for the delivery to arrive at the house, the status changed to "delayed" due to "operational issues". I had to drive back to where I had been staying and return the next day to get the item, costing a significant amount of time and money for gas. I have had similar issues with FedEx in the past and I will certainly look for purchase options in the future from vendors who do not use FedEx.


Rated 1 out of 5 stars
By Denny on Nov 1, 2024

Poor treatment

Chewy, ad on TV, 20% off 1st order. I did not get the discount. Had to call, had to talk to super. Pretty poor way to treat people.

Chewy, ad on TV, 20% off 1st order. I did not get the discount. Had to call, had to talk to super. Pretty poor way to treat people.


Rated 5 out of 5 stars
By Sandra on Jun 30, 2024

Cancer

He seems to have perked up some and runs a little with my younger dog. I think it is making him very hungry. He is always "always asking me for treats." The vet

He seems to have perked up some and runs a little with my younger dog. I think it is making him very hungry. He is always "always asking me for treats." The vet is very pleased with how he looks, his tests, and how he acts with him at an appointment. I would recommend, but I think you should try other avenues of treatments first.


Rated 1 out of 5 stars
By alfred on Oct 6, 2024

Didn’t stop water intake

Went from 50 oz of water to over 60. 13 lb dog.

Went from 50 oz of water to over 60. 13 lb dog.


Rated 4 out of 5 stars
By Sandra on Apr 6, 2024

Prescribed by my Vet

I have a Miniature Schnauzer who has Cushings. This was recommended for her by one Vet. Another told me it was not used much anymore, but the dog is doing so well

I have a Miniature Schnauzer who has Cushings. This was recommended for her by one Vet. Another told me it was not used much anymore, but the dog is doing so well on it she simply said we will keep her on it. My dog takes it twice a week and is doing just fine so I would of course recommend this for any dog that has Cushings.


Rated 1 out of 5 stars
By Elaine on Apr 13, 2024

A very high cost increase

My fur baby is on his medication due to Cushing’s disease. I am on Social Security only and I’m afraid of having to go off of this medication due to your rate i

My fur baby is on his medication due to Cushing’s disease. I am on Social Security only and I’m afraid of having to go off of this medication due to your rate increase.


Rated 5 out of 5 stars
By tracy on Jan 14, 2025

Helped my pup who had Cushings

Cushings meds

Cushings meds


Rated 5 out of 5 stars
By Mary on Mar 23, 2024

Great service and prompt delivery.

Will need this Lysodren for the future. Would love a discount in price due to my limited income

Will need this Lysodren for the future. Would love a discount in price due to my limited income


Rated 5 out of 5 stars
By Mary on Dec 10, 2024

Fast delivery

Thank you!

Thank you!