Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Medium Dogs

By Nutramax
Rated 4.6383 out of 5 stars

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$42.99Chewy Price
$43.99Chewy Price
$40.84Autoship Price
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About This Item


  • Denamarin contains s-adenosylmethionine (SAMe) to help increase your dog’s glutathione levels and support his liver’s detoxification capabilities.
  • Silybin found in Denamarin has shown better absorption in dogs than the milk thistle extract found in many other products.
  • Supporting your dog’s liver health promotes the liver’s ability to remove toxins, store energy, aid digestion and support the immune system.
  • Nutramax Laboratories Veterinary Science has made supplements to support joint health, digestive health and overall wellness for over 30 years.
  • Veterinarian formulated with high-quality ingredients to ensure supplement safety.

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Nutritional Information

Feeding Instructions


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Top IngredientsActive Ingredients: S-Adenosylmethionine, Silybin A+B.Active Ingredients: S-Adenosylmethionine, Silybin A+B.Active Ingredients: S-Adenosylmethionine, Silybin A+B.S-Adenosylmethionine 225 mg, Silybin-phosphatidylcholine complex (SPC)* 82 mg, *Providing 24 mg of Silybin A+B....Actual Ingredients: S-Adenosylmethionine.
Breed SizeSmall Breeds, Medium Breeds, Large BreedsExtra Small Breeds, Small Breeds, Medium Breeds...Small Breeds, Medium Breeds, Large BreedsMedium BreedsMedium Breeds, Large Breeds, Giant Breeds
Health FeatureLiver CareLiver CareLiver CareLiver Care, Vitamins & MineralsLiver Care
LifestageAdult, SeniorAdult, SeniorAdult, SeniorAll LifestagesAdult, Senior
Food FormSupplementSupplementSupplementSupplementSupplement

Questions & Answers

18 Customer Questions

When do you think the Denamarin tablets in?

Which is easier for the dogs to take, the regular or chewable?
Answer by ChewyJun 20, 2019
Ease of administration between these tablets and the chews will vary from pet to pet. This medication should be administered on an empty stomach at least 1 hour before eating. If you must mask with food it is recommended to use no more than a tablespoon.

How long can my dog stay on denamarin?
Answer by ChewyMay 09, 2018
This depends on the current condition of your dog. These tablets are safe for long term use. We recommend consulting a veterinarian for accurate feeding regimes based on your dog's health.

Are there any side effects from taking Denarmarin
Answer by ChewyFeb 04, 2020
The active ingredients in Denamarin have been shown to be well-tolerated by both dogs and cats with a wide margin of safety. We advised consulting with your veterinarian before administering.

ReviewsWrite a Review

Rated 4.6383 out of 5 stars
459 Ratings
Would recommend to a friend

446 Customer Reviews

Rated 2 out of 5 stars
By Kc83 on Nov 29, 2023

impossible to make dog eat. far too big

My dog will eat anything. Any slight flavoured or chewable tablet he will eat without the need of disguising. Any other pill he eats in a pill pocket no fuss. This is only one he’s ever managed to spit out every single time. i have to tr multiple times and ita costing a lot in pill pockets. sometimes i just cannot get them in him without forcing so i give up. he is a rescue and very sensitive with trust issues so i can't do this to him unless its life or death and these are supplements. He is within the weight range and they are very big and they are very hard. Also, they are BRIGHT blue. if you get it on your fingers it stains and does not wash off easily. why are they bright blue?what kind of artificial unnecessary additives are in them?

Rated 1 out of 5 stars
By Toni on Oct 6, 2023

Stupid Caplets

Whyyy??? So frustrating that these were not chewable and I missed that when ordering. You have to give this med either one hour before a meal or two hours after a meal. Then you have to crush the heck out of it to wrap in peanut butter to try and get it down their throat. You cannot prep the med earlier either because the humidity makes it like glue. I use like four things (utensils and bowls) to prep this med to be able to give it to my dog. I bought two bottles and most likely will not purchase again for my senior dog. It’s like chasing a toddler around my house trying to get her to take it. Such a mess. Do not buy unless you want to get in a workout to get your dog to take this!

Rated 5 out of 5 stars
By Christine on Nov 22, 2023

My senior pup has liver issues

Denamarin has been helpful in battling her elevated liver enzymes. Although just a supplement, I believe it is an important component in her overall medical care for her liver giving her every chance at a long and healthy life.

Rated 5 out of 5 stars
By Rita on Nov 12, 2023

Tablets in bottle better

I switched to the brown tablets in the bottle instead of the turquoise tablets in the blister packs. Since my Corgi won’t take tablets any way except pushing down her throat, I no longer have turquoise-stained fingers!!!

Rated 5 out of 5 stars
By PeachyQ on Sep 3, 2023

Beware of melting in summer heat

This product in all of its forms has been a life saver for several of my dogs over the years. Somehow my product was changed from the blister pack with blue tablets to these tan coated bottle of tablets. This product has several storage reuirements and we've had some record breaking heat waves so i checked the temperature in the box when it arrived and it was over 100F degrees and the tablets were melted inside. I also noticed my dog was not feeling well. Anyway, the blister pack tablets seem to be better in the heat. I'm grateful for this product and of course, we all know Chewy is going to make everything okay again. Just a note: please be aware of heat effects on medication shipments.

Rated 3 out of 5 stars
By JR on Aug 27, 2023


I’ve been giving this to my dog since well before I can remember. Recently the shape was changed from capsule to tablet; the tablets are not easy to camouflage in anything because they are so large. In addition, I have experienced, several times, a shortage in the product and was in a panic; I contacted the company. Thank God, this is not a prescription, as then it would be required to take daily (for which I wouldn’t have enough of and my dogs would wind up going into withdrawal with side effects).

Rated 5 out of 5 stars
By Terry067 on Oct 16, 2023

My 15 year old Boston Terrier has been on Denamarin for several years. It has helped keep his liver in check and I can't be happier with the results. I hope to use this medication for many years to come.

Rated 5 out of 5 stars
By Sandra on Oct 30, 2023


Just to let you know Will not be needing any auto fills on Nutramax. My fur baby Bandit passed away this morning. Thank you for all you've done for Bandit.

Rated 5 out of 5 stars
By Lindy on Jul 24, 2023

Noticeable improvement

My 14 (almost 15) year old yorkie mix had blood work down that showed extremely high liver enzymes, ALK-P specifically was over 2000. Less than 1 month on this supplement he was down to under 800. He is on this daily and we will continue to monitor but There is a very noticeable improvement in his alertness and energy level.

Rated 5 out of 5 stars
By Elizabeth on Nov 9, 2023


The Denamarin has been very helpful in helping my dog recover from a liver infection.