Prascend (Pergolide) Tablets for Horses, slide 1 of 1

Prascend (Pergolide) Tablets for Horses, 1 mg, 10 tablets

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Prascend Tablets for Horses is a dopamine receptor agonist that works to help control the signs of PPID —also known as Cushing’s disease— in your horse. PPID is known to affect over 20% of older horses and ponies, generally over the age of 15 years old. Prascend Tablets for Horses can offer you an easy and effective way to help manage symptoms, while also helping to treat the pain and discomfort associated with Cushing’s disease. Unmanaged Cushing’s disease in your horse can impact her overall health and wellbeing, including weight loss and delayed shedding. Horses treated with Prascend Showed improved clinical signs within 3 months with 75% of cases considered treatment successes.

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For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses.

Possible Side Effects

To read more about possible side effects, please review the package insert.

Drug & Food Interactions

Pease consult with your veterinarian for any Food and Drug interaction concerns.


Treatment with PRASCEND (pergolide tablets) may cause inappetence. The use of PRASCEND in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation. PRASCEND is approximately 90% associated with plasma proteins. Use caution if administering PRASCEND with other drugs that affect protein binding. Dopamine antagonists, such as neuroleptics (phenothiazines, domperidone) or metoclopramide, ordinarily should not be administered concurrently with PRASCEND (a dopamine agonist) since these agents may diminish the effectiveness of PRASCEND. Keep PRASCEND in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Dogs have eaten PRASCEND tablets that were placed in food intended for horses or dropped during administration of the tablets to the horses. Adverse reactions may occur if animals other than horses ingest PRASCEND tablets. PRASCEND is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives.

  1. Prescribing Information

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  • Item Number
  • Administration Form
  • For Use With
  • Generic Name
  • Common Brand Name(s)
  • Product Form
  • Health Condition
    Cushing's Disease, Pituitary Pars Intermedia Dysfunction (PPID)
  • Drug Type


Recommended Dosage

Administer PRASCEND (pergolide tablets) orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily. The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment. See prescribing information for more dosing instructions.

Storage Instructions

Store at 68F- 77 F (20-25 C). Excursions between 59 F- 86 F (15-30 C) are permitted.


Can Prascend be used in breeding, pregnant, or lactating mares?

PRASCEND has not been evaluated in breeding, pregnant, or lactating animals. As PRASCEND is a dopamine agonist, it may interfere with reproductive hormones involved in these groups of animals.

How long until I begin seeing improvement with my horse after beginning treatment with Prascend?

Depending on the specific clinical sign, improvement may be observed beginning within 30 days and continue through 6 months of initial treatment.

What is the benefit of FDA-Approval?

Obtaining FDA approval is a strict and rigorous process. PRASCEND is manufactured according to the strict specifications set forth by the US Food & Drug Administration. PRASCEND is manufactured to provide a consistent, safe, and efficacious product.

What is the best way to administer Prascend?

PRASCEND can be hidden in an apple or treat. The tablet may be administered orally by dissolving in a small amount of water, with or without sweetener. Administer the liquid with a syringe or as a top-dressing on feed. After dissolving, the tablet should be given immediately. PRASCEND should not be crushed due to the potential for increased human exposure. See package insert for full prescribing information.

What are the benefits of treatment with Prascend?

PRASCEND helps reduce the clinical signs of PPID and improve horses quality of life. Treatment with PRASCEND may cause loss of appetite. Most cases are mild.

What else can I do to help my horse besides treating with Prascend?

Horses with PPID will also benefit from an overall excellent general health care along with individual nutrition recommendations from your veterinarian.

  • Diet and exercise
  • Proper vaccination
  • Deworm regularly
  • Regular care from hoof to teeth
  • Body clipping, if needed

What are the signs a horse has PPID?

Signs of PPID vary widely and may be in the early or advanced stages. Often early clinical signs can go unrecognized. Below is a check list of both early and advanced signs of PPID. If you notice any of these signs in your horse, check with your veterinarian.

  • Decreased athletic performance and/or lethargy
  • Delayed shedding/decreased shedding
  • Weight loss
  • Cresty neck/fat pads around tail head/swollen sheath
  • Excessive thirst
  • Excessive urination
  • Abnormal (increased or decreased) sweating
  • Loss of muscle mass
  • Laminitis
  • Recurrent infections

What breeds are most prone to developing PPID?

PPID may be seen in all breeds of horses including ponies. It also affects both male and female horses.

What age is PPID usually seen?

PPID is not just an old horse disease. In rare cases, it has been seen in horses as young as 5 years of age.

How is PPID diagnosed?

Your veterinarian will examine your horse and determine if your horse should be tested for PPID. A blood test is often performed to determine if your horse is positive for the disease.

What is the treatment for PPID?

Pergolide is considered the treatment of choice for PPID. PRASCEND is the most proven treatment available to control the clinical signs associated with PPID in horses. PRASCEND is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives.

Is there a cure?

No. There is currently no cure for PPID. It is a chronic, lifelong disease that requires daily medical treatment. However, treatment with PRASCEND can reduce clinical signs of the disease, improving the quality of life for the affected horse. PRASCEND has not been evaluated in breeding, pregnant or lactating horses.

Rating: 5.0 of 5 stars 4 Reviews 4 Reviews 5 out of 5 Stars

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  • 5 out of 5 stars

    Education needed

    By MaryC on Sep 11, 2021

    I have been using this medication for my senior horse for 2 years now. I like that I can save money with Chewy but it seems that Chewy doesn't understand how this medication is used. It is a lifelong treatment that would never be prescribed for just one tablet. They need to make whole boxes available. I hope this statement is seen by the persons making that kind of decision.

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  • 5 out of 5 stars

    Vet ordered

    By Whimmy on May 9, 2021

    My mare showed typical sounds of cushings so we did the test, placed her on the meds and within 5 days she started to show signs of improvement. Now about ordering from chewy vs the others, I love the ordering options of by the pill, not by the box of 30. It makes a lot more sense! They still come in the sheets of 10 (which chewy can edit for your order), but in a clear bag which I prefer! The boxes never survive the month for me. Also I can put the equioxx bottle in the baggie and keep all my old lady's meds together! Glad I found them on chewy.

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  • 5 out of 5 stars

    The Doc gets meds.

    By Willieboy on Jun 20, 2021

    Thank Goodness Chewy is getting meds for Larger animals !! The price was Great !! It was easy to order !! Thanks Chewy !!

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  • 5 out of 5 stars

    Pracend for my Savannah

    By Wendy on May 27, 2021

    Price with extra discount is Good Got my order quick!

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