Vectra 3D Flea & Tick Spot Treatment for Dogs, 21-55 lbs

By Vectra
Rated 3.6768 out of 5 stars

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This Item – Vectra 3D Flea & Tick Spot Treatment for Dogs, 21-55 lbs, 3 Doses (3-mos. supply)
Rated 3.6768 out of 5 stars
$49.99Chewy Price

Spend $100, Get $30 eGift Card with code: FALL

Total Price: $191.34

About This Item


  • This monthly treatment helps protect dogs ages 8 weeks and older weighing 21–55 pounds from fleas, ticks, mosquitoes, lice, mites plus biting and sand flies—excluding mange mites.
  • Starts to reduce flea bites in five minutes and kill fleas in four hours.
  • Works to repel and kill fleas, ticks and mosquitoes—no biting required!
  • This easy-to-apply topical treatment is quick drying, fragrance free, non-greasy and waterproof after 24 hours.
  • No prescription required.

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Learn More About Vectra From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

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Top IngredientsDinitefuran, Pyriproxyfen, Permethrin.Dinitefuran, Pyriproxyfen, Permethrin.Dinitefuran, Pyriproxyfen, Permethrin.Dinitefuran, Pyriproxyfen, Permethrin.Active Ingredients: Fipronil 9.8%, (S)-Methoprene 8.8%.
LifestagePuppy, Adult, SeniorPuppy, Adult, SeniorPuppy, Adult, SeniorPuppy, Adult, SeniorAdult
Breed SizeMedium BreedsLarge BreedsSmall BreedsExtra Small BreedsSmall Breeds, Medium Breeds

Questions & Answers

10 Customer Questions

My dog weighs 106. Can I use 2 of the 21-55 tubes at once

Do I treat my dog with 3 doses right away, or use one dose a month?
Answer by ChewyMay 06, 2020
This flea and tick treatment should be administered once a month.

Some products that are safe for dogs are NOT safe for use around cats. I have 2 dogs and 1 cat is it safe to use on the dogs with a cat in the house?
Answer by ChewyJun 22, 2020
Due to their unique physiology and inability to metabolize the permethrin in Vectra 3D® for Dogs, this product must not be used on cats. As a precaution, when using this product in households with both dogs and cats, please keep the dog(s) that have been treated with a Vectra 3D® product separated from cats until the product has completely dried. Once dry, cats and dogs may again interact freely. Average drying time for Vectra 3D is 6-8 hours however drying times can vary. To ensure that the product is completely dry, you may run a facial tissue along the application site. When there is no evidence of moisture on the tissue, the product is dry.

Does this need veterinarian approval?
Answer by ChewySep 18, 2019
This treatment does not require a prescription.

ReviewsWrite a Review

Rated 3.6768 out of 5 stars
99 Ratings
Would recommend to a friend

99 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Disappointed on Sep 2, 2023

does not work

Tried and gave this brand a chance but it does nothing to work to solve the fleas on my dog. This is the first year battling fleas ever and I have also treated yard and home along with this product. Don’t waste you’re money.

Rated 5 out of 5 stars
By cw on Jul 11, 2023

no ticks

This product works great! First year that I have no ticks. I have always gave my dogs the digestive tick medicine to find out that it doesn't provide effective Lyme disease for the full three months and now my dog has Lyme disease, plus the ticks always came in the house and I got tick bites. This product repels ticks or kills ticks and none of us have ticks!

Rated 5 out of 5 stars
By Angela on Apr 30, 2023


Kind of a pain to apply, because you have to get it directly on the skin all the way from the neck to base of tail. Then when you're done it does leave some wet residue in your dog's hair, which you're not supposed to touch until it's dry. My dog was told to use this by his vet, and we have been and it seems to work just fine, but it does make his back itchy. I just wait until its fully dry and brush/scratch his back. But we havent had any issues with flea or ticks, etc.

Rated 5 out of 5 stars
By Kobi on Apr 28, 2023

A Very Good Product

We first used Vectra 3D about 13 years ago when we lived in Maryland. Fleas got out of hand, they were everywhere and our regular flea/tick product did nothing. I researched flea/tick topical products for a long time and found Vectra to be one of the least toxic to dogs and still do the job. We've stuck with Vectra ever since and no fleas or ticks. We now live in the middle of the woods on a mountain, so a good test area.

Rated 5 out of 5 stars
By Winston on Sep 5, 2023


Ordering was easy, shipping and tracking was easy, communication good. I like Chewy!

Rated 5 out of 5 stars
By Yazmin on Jun 7, 2023


I live in Florida and my 4 dogs had a good amount of fleas I administered this as instructions and on May 25 today is June 7 so far zero fleas on them loved it

Rated 1 out of 5 stars
By Bobster on May 16, 2023

Too many side effects

I bought this and opened the package. When I looked at the precautions it showed a lot of side effects. It was my mistake but I won’t be giving this to my dog.

Rated 1 out of 5 stars
By AussieMom on Mar 23, 2023

ZERO stars, plenty of Benadryl

My dog was a healthy adult when I tried this, and within a few minutes of application, he went from being his usual calm, sweet self to agitated, rubbing against the furniture, rubbing his back on the floor, crying, and yelping a few times. I called the vet, who directed me to give a dose of Benadryl and then bathe him ASAP and I soaped him at least twice in the first bath. It took a few days of Benadryl and several more baths over the weekend to get my guy back to a more normal condition.

Rated 4 out of 5 stars
By Connie on Mar 22, 2023

vet recommended

As far as I can tell it is repelling the fleas and ticks. It is taking a few days for the product to "rub-in". Bella has long hair and the oiliness is noticeable in the places I put the product.

Rated 5 out of 5 stars
By De on Sep 7, 2023


Quick, efficient and done. Thank you!