Zymox Hydrocortisone Free Dog & Cat Ear Infection Solution, 1.25-fl oz bottle

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About This Item

At a Glance

  • All Lifestages
  • All Breeds

Details

  • Paw-fect for dogs and cats of all ages, this solution works to soothe ear infections, redness and inflammation.
  • Gentle, no-sting formula helps ease painful ear infections caused by germs, fungi and yeast.
  • This natural solution contains no medication or hydrocortisone—ideal for pets with sensitive skin.
  • No pre-cleaning of painful ears required—simply fill the ear canal and let the solution get to work.
  • ZYMOX's LP3 Enzyme System helps clear ear secretions and promotes healthy ears.

Ingredients

Instructions

Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.

About ZYMOX

Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.
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Questions & Answers

3 Customer Questions


Is this product safe for pregnant dogs?

Answer by ChewyAug 01, 2020
These ear drops are suitable to be used on any age dog, cat, exotic, as well as those that are pregnant or lactating.

Does this product leave an oily residue?

Answer by ChewyOct 08, 2019
This product should not leave behind any oily residue.

Would this be safe to use for a Guinea pig?

Answer by ChewyApr 03, 2023
This solution may be used with small pets such as a Guinea pig.
4.5
Rated 4.5 out of 5 stars
74 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

91% Positive

Ease of Use

97% Positive

Effectiveness

97% Positive

Safety

92% Positive

34 Customer Reviews



Rated 4 out of 5 stars
By Adam on Sep 10, 2025

Helps more than just ear solution

My lab/staffie mix has ear issues/allergies and regular ear wash doesn't always work the best. Using this just once a day seems to clear up those red, itchy ears

My lab/staffie mix has ear issues/allergies and regular ear wash doesn't always work the best. Using this just once a day seems to clear up those red, itchy ears of his though....


Rated 5 out of 5 stars
By Theresa on Sep 23, 2025

This works

I’ve used this for years on my Shih Tzu and my cats. It helps keep their ears clean and itch free. Helps with inflammation from allergies as well.

I’ve used this for years on my Shih Tzu and my cats. It helps keep their ears clean and itch free. Helps with inflammation from allergies as well.


Rated 5 out of 5 stars
By Cherry on Nov 28, 2025

Love that it is steroid free

This helps relieve itchiness quickly. Very useful to always keep in stock.

This helps relieve itchiness quickly. Very useful to always keep in stock.


Rated 5 out of 5 stars
By Amanda on Feb 14, 2025

Works, and not dangerous!

I have a water dog, plus she likes to roll around and grow stuff which doesn’t help the ears. Honestly, I need to get around to using the Zymox branch regular ear,

I have a water dog, plus she likes to roll around and grow stuff which doesn’t help the ears. Honestly, I need to get around to using the Zymox branch regular ear, cleaning wipes and solution more. I saw it at a pet store recently and thought that prevention is better than a cure but if need a cure, this works really well. It is a go to. Completely avoids vet visits. You don’t have to be consistent, and make sure that your dog ears are dry. And be sure to have a nice clean dry washcloth nearby so you can diligently wipe out the excess for a few minutes each time. Honestly, don’t know what we would do without this product. It’s a really important component of our care kit. I’m very grateful that they make it. it especially hydrocortisone free.


Rated 5 out of 5 stars
By Laurie on May 11, 2025

Zymox works well!

Use on my Pomeranian dog, keeps her from getting yeast infections in her ears. She likes to play in water to keep cool in summertime. use once A Day for 14 days

Use on my Pomeranian dog, keeps her from getting yeast infections in her ears. She likes to play in water to keep cool in summertime. use once A Day for 14 days.


Rated 5 out of 5 stars
By VICKI on Jun 30, 2025
Top 1000 Contibutor

Quality at a good price

Zymox items are effective, affordable and work well for me. Always my go-to brand.

Zymox items are effective, affordable and work well for me. Always my go-to brand.


Rated 5 out of 5 stars
By Lisa on Feb 20, 2025

Great product

Used this product when working in the veterinary field, and continue to use it and recommend it on a personal level. Zymox is great for environmental allergies affecting

Used this product when working in the veterinary field, and continue to use it and recommend it on a personal level. Zymox is great for environmental allergies affecting the ears, and good with food allergy infections. Also like to use it preventatively after bathes.


Rated 5 out of 5 stars
By Jacqueline on Dec 9, 2025

Fast shipping

Good price

Good price


Rated 5 out of 5 stars
By Joyce on Nov 2, 2024

Buddy’s Infection Free Ears

Buddy, a 12-1/2 yr.old Shih-Tzu had both ears badly infected at age 1-1/2 yrs. His vet recommended using every day for 1 week & maintenance 3x/week. He has never

Buddy, a 12-1/2 yr.old Shih-Tzu had both ears badly infected at age 1-1/2 yrs. His vet recommended using every day for 1 week & maintenance 3x/week. He has never had another ear infection! I believe in ZYMOX!!


Rated 5 out of 5 stars
By Stephanie on Feb 23, 2025

Works great for minor ear problems

I’d recommend for maintenance first your dogs ears.

I’d recommend for maintenance first your dogs ears.