Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone, 1.25-fl oz bottle

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About This Item

Details

  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.

Ingredients

Instructions

Learn More About Zymox From Our Team of Experts

Related to This Item

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.

About ZYMOX

Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.
Shop ZYMOX

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Ingredients           
Active Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose, Glucose Oxidase, Glycerin, Hydroxypropyl Cellulose,
Active Ingredient: Hydrocortisone 1.0%., Inactive Ingredients: Benzyl Alcohol, Bet-Glucanase, Cellulase, Dextranase, Dextrose, D-Mannose, Glucose
Propylene Glycol, Glycerin, Benzyl Alcohol, Dextrose, Hydroxypropyl Cellulose, Purified Water, Potassium Iodide, Lactoperoxidase, Glucose Oxidase,
Benzyl Alcohol, Beta-Glucanase, Cellulase, Dextranase, Dextrose, D-Mannose, Glucose Oxidase, Glycerine, Hydroxypropyl, Lactoferrin Cellulose,
Active Ingredients: Hydrocortisone 0.5% USP Inactive Ingredients: Benzyl Alcohol, Deionized Water, Dextrose, Glucose Oxidase, Glycerin,
Purified Water, Glycerin, Coco-Glucoside, Propylene Glycol, Benzyl Alcohol, Lactoperoxidase, Lactoferrin, Lysozyme, Glucose Oxidase, Zinc Gluconate.
Exclusive Formulation of Chelated Silver and Distilled Water.
Purifed Water, Glycerin, Coco Glucoside, Propylene Glycol, Benzyl Alcohol, Lactoperoxidase, Lactoferrin, Lysozyme, Glucose Oxidase, Zinc Gluconate.
Deionized Water, Propylene Glycol, Aloe Vera, SD Alcohol 40, Lactic Acid, Glycerin, Dioctyl Sodium Sulfosuccinate, Salicylic Acid, Fragrance, Benzoic
Deionized Water, Propylene Glycol, Aloe Vera Gel, SD Alcohol 40, Lactic Acid, Glycerin, Dioctyl Sodium Sulfosuccinate, Salicyclic Acid, Vitamins A, C,
Benzalkonium Chloride, Alcohol, Thymol, Phenol, Phenyl Salicylate, Benzoic Acid, Water, Aloe Vera, Tromethamine Benzyl Alcohol, Disodium EDTA, White
Purified Water, Propylene Glycol, Salicylic Acid, Alpha-Hydroxy, Ethyl Alcohol, Acetic Acid, Avena Sativa Oatmeal, Fresh Scent, Boric Acid.
Breed Size           
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
—
Health Feature           
Ear Care
Ear Care
Ear Care
Ear Care
Ear Care
Ear Care
Ear Care
Ear Care
Ear Care
Ear Care
Ear Care
Ear Care
Grooming Feature           
Medicated
Medicated
Medicated
Medicated
—
—
Medicated
—
—
Deodorizing
Cruelty-Free
Deodorizing, Medicated

Frequently bought together

Questions & Answers

20 Customer Questions

Is this safe for cats as well ?

Answer by Suzanna • May 14, 2021
Yes

How many drops do you put in ?

Answer by Chewy • Nov 24, 2022
The amount of drops to use will vary based on individual pet and their condition. You should squeeze this product liberally into the uncleaned ear, filling their ear canal. Gently massage and work into the infected area. Wipe away any excess. Apply for 7 days, 14 days for chronic infections. It is safe for extended use on persistent cases.

I was putting another ear infection medicine on my dog. When I get this one do I clean my dogs ears before putting the zymox or do I just put it ?

Answer by Chewy • Apr 30, 2021
Cleaning the ear prior to use of this product is not recommended

Does this contain a drying agent?

Answer by Chewy • Apr 18, 2019
Zymox does not contain any drying agents.
Reviews
Write a Review
4.8
Rated 4.8 out of 5 stars
5499 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

85% Positive

Ease of Use

91% Positive

Effectiveness

91% Positive

Safety

88% Positive

3248 Customer Reviews

Rated 5 out of 5 stars
By Doodle Mom on Oct 4, 2025

Best treatment for my dogs ear infection

I have a doodle that my former vet once said had the hairiest ear canal she had ever seen. He's prone to ear infections if his ear hair gets thick or sometimes in

I have a doodle that my former vet once said had the hairiest ear canal she had ever seen. He's prone to ear infections if his ear hair gets thick or sometimes in summer. I spent $$$ at the new vet after my vet had retired and tried so many products when he had a stubborn ear infection. This worked even after the new vet said there was nothing I could do but put my dog on very expensive restrictive diet due to unknown allergies. This stuff is amazing and worth every penny. I hope it works as well for you and your fur baby/ies.

Rated 5 out of 5 stars
By Katherine on Oct 12, 2025

No more Vet needed

My neighbor told me she used this product so I gave it a try. Works great & have not had any problems yet with infection in her ear. Has saved me lots of money &

My neighbor told me she used this product so I gave it a try. Works great & have not had any problems yet with infection in her ear. Has saved me lots of money & wasted time & my cats discomfort just by using ZYMOX per instructions on bottle. A warning though, give it some body heat so they don’t mind it so bad! Who likes cold stuff hitting your eardrum?

Rated 5 out of 5 stars
By Karen on Oct 3, 2025

Save me a visit to the vet

Zymox Otic dog ear infection treatment with hydrocortisone saved me a trip to the vet. vet told me over the phone to get this. Can I used it for the prescribed seven

Zymox Otic dog ear infection treatment with hydrocortisone saved me a trip to the vet. vet told me over the phone to get this. Can I used it for the prescribed seven days and it cleared up before our appointment time so was able to cancel the appointment with the vet. Saved me over $100 so I’m a very very happy camper. I will use this from now on first before contacting the vet.

Rated 4 out of 5 stars
By Stephanie on Sep 1, 2025

Effective

It was my first time trying this product and it helped my dog's ear infection. I didn’t want to pay $100+ for a vet visit since it’s gotten very expensive. I read

It was my first time trying this product and it helped my dog's ear infection. I didn’t want to pay $100+ for a vet visit since it’s gotten very expensive. I read the reviews and decided to try it out and I’m pleased with the improvement I’ve seen. I unfortunately was not consistent for the 7 days that it states due to work, but I did do it for 3-4 days and I noticed less irritation/ inflammation and less wax coming out. I believe it relieved my dogs ear discomfort since he would constantly shake his head before this product and seemed to always be uncomfortable and stressed. :( After using this product he seems calmer, less pain, and no shaking. His demeanor is better (those who know your dogs body language very well will understand. ) Plus it seemed to clear the actual infection but my dogs normal earwax still continues but very little and that is expected anyway. Regardless I’m content since I have a senior boy and wanted to alleviate his pain and it seemed to be successful! Will continue to shop at Chewy.

Rated 5 out of 5 stars
By Lyn on Sep 2, 2025

What my dog needed!

My vet checked my dog's ear and said his itching and irritation was due to allergies, not an infection. My dog's ear only seemed to get worse regardless of the other

My vet checked my dog's ear and said his itching and irritation was due to allergies, not an infection. My dog's ear only seemed to get worse regardless of the other remedies we used to try and help relieve his "allergies". I Googled his symptoms and when all of the listed symptoms that he had - concluded to an infection, I was so upset. Spent hundreds of dollars at the vet just to Google his symptoms and find this AMAZING product that solved my dog's ear issue immediately! Even though the treatment lasts 7 days, I saw immediate relief for my dog after the first use! Love this product! 10/10!

Rated 5 out of 5 stars
By Kathy on Oct 3, 2025

It works great!!!

A lady told me how well Zymox works with her Boxers. I bought it and used it for 8 days in a row (cleaning her ears twice with Epiotic Advanced also sold by Chewy)

A lady told me how well Zymox works with her Boxers. I bought it and used it for 8 days in a row (cleaning her ears twice with Epiotic Advanced also sold by Chewy). It totally cleared up her ear infection! This is much cheaper than a vet visit! I'm SO GLAD to know about Zymox! I'll keep it on hand from now on.

Rated 5 out of 5 stars
By Pam on Oct 18, 2025

Effective with stopping overgrowth quickly

My vet recommended this for when we see any dark wax starting in our pugs ears and it works like a charm. It's saved us multiple vet visits and clears things up In

My vet recommended this for when we see any dark wax starting in our pugs ears and it works like a charm. It's saved us multiple vet visits and clears things up In a few days. Highly recommend to have on hand for dogs prone to ear infections

Rated 5 out of 5 stars
By Trevor on Sep 2, 2025

Killer for our Danes ear infection !

Our Great Dane keeps getting ear infections unfortunately due to having allergies and scratching a little extra. Got tired of taking him into the vet as he 1. Get

Our Great Dane keeps getting ear infections unfortunately due to having allergies and scratching a little extra. Got tired of taking him into the vet as he 1. Get scared there and 2. Is getting expensive to keep getting pills to deal with his ears. Could tell this stuff immediately helped with smell and heat that resonates off his ears dissipating over the first couple of days. Have to use it for about of eeek but a lot cheaper than constantly going to the vet so give this stuff a try !

Rated 5 out of 5 stars
By Diane on Oct 16, 2025

A gel that WORKS!

This really helps keep our dog from the constant ear infections & costly trips to the vet. We clean her ears weekly with this. Since this is a gel, it goes where

This really helps keep our dog from the constant ear infections & costly trips to the vet. We clean her ears weekly with this. Since this is a gel, it goes where it is needed & not all over you & the dog like the liquid ear washes.

Rated 5 out of 5 stars
By Sue on Sep 29, 2025

Works!

I've had several dogs over the years that tend to minor ear irritations that can turn into infections if not treated.Especially during allergy season. I've

I've had several dogs over the years that tend to minor ear irritations that can turn into infections if not treated.Especially during allergy season. I've kept this on hand for many years and have saved many vet visits by using at the 1st indication of ear trouble.