ZYMOX Otic Dog & Cat Ear Infection Treatment with Hydrocortisone, 1.25-oz bottle - Chewy.com

Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone

By Zymox
Rated 4.8239 out of 5 stars

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$23.79Chewy Price
$31.99Chewy Price

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About This Item


  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.

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Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

Questions & Answers

57 Customer Questions

Is this safe for cats as well ?
Answer by SuzannaMay 14, 2021

Will the 1.25 ounce bottle be enough to treat 1 dog, both ears?
Answer by ChewyOct 08, 2017
The 1.25 ounce bottle will provide more than 2 weeks worth of daily maintenance to both ears.

how long do you massage the base of your pet's ear and keep the liquid in the ear canal?
Answer by ChewyAug 24, 2018
Massage the base of your pet's ear until the treatment has coated the infected area.

Is this safe if ingested? I have three dogs that like to lick/clean each others ears and want to ensure this is safe.
Answer by ChewyOct 02, 2018
Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use.

ReviewsWrite a Review

Rated 4.8239 out of 5 stars
2351 Ratings
Would recommend to a friend

2350 Customer Reviews

Rated 5 out of 5 stars
By Yoshi on May 26, 2023

Prone to ear infections

My labradoodle likes to jump in the creek everyday and is prone to ear infections bc of his floppy ears, Such a conundrum. I clean his ears out when we come in. I’ve spent a ton of money in the past 4yrs taking him to the vet and on meds bc of this. He’s been prescribed all the ear wash and different meds they’ve thrown at me. They work for the time being, but I’ve yet to find the solution to his problems until this. It was prescribed to me by a senior vet, he told me the wash often kills the good bacteria. I’m not sure how it works, but for my guy, it’s super beneficial. Don’t overuse, but it’s a really good option when ur pup is in need.

Rated 5 out of 5 stars
By Jilly on Apr 24, 2023

No more head shaking

Racal Max is a rather stubborn chihuahua and typically refuses ear cleaning He recently experienced an ear infection. After research and seeing this in my Chewy app I purchased it. The first 2 applications he fought, the 3rd he actually went to table it was at and sat by it. He tilted his head and let me take care of them. It was very obvious he felt better and associated these drops. After 5 days he was back to holding ears up, no more shaking his head, or whining while rubbing his ears. Did it for the full 7 days and he is great. Thankful for quick delivery and quick results. Will be keeping this on hand, worked as good as vet prescribed ear drops!

Rated 5 out of 5 stars
By rusty on May 14, 2023

good product

This product has done what many claim but come up short. Very satisfied cleared up our Lab's ear infection working on first day, got better day by day. Back to normal. Koda's infection was caused by excessive swimming over 9 hours in pool over a 2 day weekend. Now I make sure his ears are Completely Dried after anytime he gets them wet Koda likes to put his entire head under water looking around for toys etc. So ZYMOX along with completely drying ears Koda Back to Perfect

Rated 5 out of 5 stars
By Eyedla on May 18, 2023

Amazing stuff

My lab/pit mix had deep dark wax in his ears and shaking his head constantly. It hurt him just to touch his ears. Our regular routine to clear it up wasn’t working. After the first application the head shaking stopped. By the third day (today) it no longer hurts to touch his ears and the amount of wax has greatly reduced. I expect it to clear completely over the next few days. The cleanser is thick - more like oil consistency than water, so it stays in place longer to clear the infection. I highly recommend this

Rated 5 out of 5 stars
By Steph on May 20, 2023

Saved me a vet visit

I honestly thought this product wasnt going to work but its honestly a money saver. My dog Zeus has SEVERE allergies so ear infections are common for us. I gave this product a try since at the time I didn't have much to take my dog to see his doctor and I'm so glad i did. I've spent THOUSANDS of dollars at the vet and never was i recommended this. In a week my dogs ears cleared up, thanks to everyone else reviews as well. Saved me 400$ at the vet ! 10/10 .

Rated 1 out of 5 stars
By Jay on May 16, 2023

Do not use this product.

After using this product for only three days, Sofia lost her hearing. I pray it is not permanent. Her total demeanor has changed. She cannot hear us at all. She is not even responding to my husband coming home. He walked right in and stood over her. She did not even flinch. I will be calling for a refund and am warning other dog owners to never try this. Heartbroken that I did this to my baby girl.

Rated 5 out of 5 stars
By DeeAnna on Apr 19, 2023

helpful ear meds

My dog got a bad ear problem possibly from me putting too much dog shampoo and water in her ears and not getting them clean and dry enough... all of the sudden they were red swollen and STINKY! A lot of dogs with floppy ears have problems with chronically wet, moist ears or yeast overgrowth in there ears... this stuff worked like magic! put it in rub it and let it be, repeat for 7 days...and no cleaning first!! After a week her ears were looking better and feeling much better!!! and the little bit of hydrocortisone in it helped with the head shaking and scratching also giving her ears a chance to heal

Rated 5 out of 5 stars
By LillieMom on Apr 25, 2023

So far GOOD!

I am seeing improvement in the amount of brown gunk is coming out of her ear. I did the whole bottle of medicine from the vet but she still has the stuff in there. And her ears seems to really itch. In fact last night she seemed to be asking me to "fix" her ear. She sat very still while I prepared to clean her ears. Directions are to drop into the ear. She absolutely won't tolerate that. Been using a soaked Qtip and having success.

Rated 5 out of 5 stars
By Rachel on May 7, 2023

Thank the gods!

I'm constantly taking my 2 doggos to the vet with ear problems. I can't continue to afford it. I googled, seen a lot of good reviews and out of desperation I ordered it. Then crossed my fingers. I am so very pleased to say that after one week, no more head shaking and scratching. I am extremely grateful to the ear gods.

Rated 5 out of 5 stars
By Cathie on Apr 1, 2023

Wonderful Product!

My 1 1/2 year old Scottie has had yeast in her ears since a puppy. The medicine the vet prescribes can cause deafness to Scotties. I have had this happen to two of my Scots. You have to be very careful to read side effects of medicine you give your dog. The vet will always tell you the product is safe and very rarely will your dog go deaf. Do you want to take a chance? I used this for 7 days as per instructions and my Scottie's ears (Lucy) have never been better. I now follow up with the cleaner twice a week. If your dog has chronic ear problems, this will work!