Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone, 1.25-fl oz bottle

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About This Item

Details

  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.

Ingredients

Instructions

Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.

About ZYMOX

Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.
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Questions & Answers

21 Customer Questions

Is this safe for cats as well ?

Answer by Suzanna • May 14, 2021
Yes

Does it wirk on ear mites in a different ears

How many drops do you put in ?

Answer by Chewy • Nov 24, 2022
The amount of drops to use will vary based on individual pet and their condition. You should squeeze this product liberally into the uncleaned ear, filling their ear canal. Gently massage and work into the infected area. Wipe away any excess. Apply for 7 days, 14 days for chronic infections. It is safe for extended use on persistent cases.

I was putting another ear infection medicine on my dog. When I get this one do I clean my dogs ears before putting the zymox or do I just put it ?

Answer by Chewy • Apr 30, 2021
Cleaning the ear prior to use of this product is not recommended
Reviews
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4.8
Rated 4.8 out of 5 stars
5907 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

84% Positive

Ease of Use

90% Positive

Effectiveness

90% Positive

Safety

87% Positive

3386 Customer Reviews

Rated 5 out of 5 stars
By Hayley on Jan 11, 2026

Product is Worth it's Weight in Gold

My dog had his first ear infection right before Christmas and couldn't get in touch with my vet's office so I ordered two bottles of this medicine. These medications

My dog had his first ear infection right before Christmas and couldn't get in touch with my vet's office so I ordered two bottles of this medicine. These medications are worth their weight in gold. Saved me from having to take my dog to the emergency veterinary clinic for treatment since my normal veterinary office was closed. Cleared up the infection in 7 days. I will always have this in the house.

Rated 5 out of 5 stars
By EH on Dec 5, 2025

Works!

I bought this based on reviews I had seen, and it did not disappoint! My dog had an ear infection from ear mites I was treating. I was concerned with how red and

I bought this based on reviews I had seen, and it did not disappoint! My dog had an ear infection from ear mites I was treating. I was concerned with how red and irritated her ear was, found this, and ordered it. It came super quick! It wasn't supposed to be here until 3 days after I ordered it, but it came the next day! As you can imagine, I was relieved. I started it right away, and it worked quickly. I couldn't believe all the gunk that came out of her ear canal! Poor girl! I used it for 14 days, and now am just going to use it twice a week to ward off ear issues since she has them often. Her ears look so nice and healthy inside, now!

Rated 5 out of 5 stars
By Julie on Jan 18, 2026

Does the job

I’ve saved money from having to take my dog to the vet by using this as preventative cleaning, especially after our showers. The pads are thin, so I take two of

I’ve saved money from having to take my dog to the vet by using this as preventative cleaning, especially after our showers. The pads are thin, so I take two of them and wrap it around a cotton ball and that seems to bulk up the material. I highly recommend this product.

Rated 5 out of 5 stars
By Danielle on Dec 9, 2025

Amazing product, works better than anything the vet prescribed

My Plott Hound was plagued with severe ear infections. He would come to me in the middle of the night crying and shaking his ears. I tried what my vet prescribed

My Plott Hound was plagued with severe ear infections. He would come to me in the middle of the night crying and shaking his ears. I tried what my vet prescribed and it made it worse. My house would smell awful from the ear infection and it kept getting worse every time I used the medication from our vet. I saw Zymox and noticed it had hydrocortisone to help with the discomfort. Enzymes were what made the product so effective. I tried it on my dog, after reading the instructions NOT to clean the ears first. I did 10 drops per ear and then massaged it and let him shake his head. It helped him feel more comfortable immediately due to the hydrocortisone. Within a couple weeks it cleared up the infection and there was never any awful smell from his ears during the use or ever again. Because he had chronic ear issues that we had fought for years without any results from other treatments, I continued to use it as a preventative treatment too. I would treat his ears with the Zymox a couple times a week, and it NEVER came back. This product saved my poor dog from so much pain, discomfort, and misery. He actually enjoyed it when I treated him with it. His breed is very susceptible to yeast & bacteria infections in the ears. Some dog breeds just are susceptible to ear issues. I recommend this product for anyone who has a dog with ear issues. It’s everything that the label says and more!! I tell everyone I know that has a dog with ear issues. I can’t say enough good things about it, or how it changed my life and my dog. Please try this for yourself, you won’t regret it and will be as happy & impressed with it. You won’t use anything else for your pets ears and will tell your friends/family to use it too!!

Rated 5 out of 5 stars
By Sharilyn on Jan 13, 2026

Worked quickly!

Zymox is amazing! I used it as directed and the awful smell from my Doodle’s ear went away quickly and the over abundance of ear wax greatly diminished. I’ve been

Zymox is amazing! I used it as directed and the awful smell from my Doodle’s ear went away quickly and the over abundance of ear wax greatly diminished. I’ve been paying more than $250 for vet visits, ear wash and medications. I’ll always try this first from now on.

Rated 5 out of 5 stars
By Ceara on Jan 14, 2026

Helped to clear up yeast infection in dog’s ears

I had gotten a prescription for this from the vet when my dog was diagnosed with a yeast infection in his ears due to allergies. When our bottle was running low

I had gotten a prescription for this from the vet when my dog was diagnosed with a yeast infection in his ears due to allergies. When our bottle was running low I was happy to find I could buy this without a prescription and a bigger bottle than the vet provided!

Rated 5 out of 5 stars
By Georgia on Jan 15, 2026

Works Well

Recommended by my vet for my German Shepherd who has chronic ear build up and then infection. You cannot use this if you dog is a swimming dog are like to dunk

Recommended by my vet for my German Shepherd who has chronic ear build up and then infection. You cannot use this if you dog is a swimming dog are like to dunk their head in water. But easy to apply, you wipe with a cotton ball to remove inner ear build up.

Rated 5 out of 5 stars
By Cheryl on Dec 22, 2025

Relief for my cat’s ear

My cat was treated by a veterinarian for a fungal ear infection, but the problem persisted even after prescription meds, until I used Zymox with Hydrocortisone

My cat was treated by a veterinarian for a fungal ear infection, but the problem persisted even after prescription meds, until I used Zymox with Hydrocortisone. This relieved the constant itching and shaking her ear, allowing her ear to heal, and providing relief. Chewy delivered it quickly too!

Rated 5 out of 5 stars
By Sheyenne on Jan 2, 2026

Works amazing for reoccurring ear infections

I used to have a german shepherd that got lots of ear infections often and spread it to my Dane. This worked wonders on her. I now only use a different product for

I used to have a german shepherd that got lots of ear infections often and spread it to my Dane. This worked wonders on her. I now only use a different product for prevention but for active ear infections. You need this! Trust me. Or expect large vet bills for not reason.

Rated 5 out of 5 stars
By Barbara on Dec 31, 2025

Easy to administer ear drops in Blue ear

I was very surprise the directions were easy to understand, and Blue was very relaxed I didn't need to give Blue any treat. after about a few days I notice Blue

I was very surprise the directions were easy to understand, and Blue was very relaxed I didn't need to give Blue any treat. after about a few days I notice Blue wasn't scratching his ear as much as a precaution, I stook Blue to our vet. Overall I definitely recommend (ZYMOX)