Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone

By Zymox
Rated 4.8543 out of 5 stars
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$23.79Chewy Price
$31.99Chewy Price
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About This Item

  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.
Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsActive Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Benzyl Alcohol, Deionized Water, Dextrose...Natural Enzymes, Lysozyme, Lactoferrin, Lactoperoxidase.Active Ingredient: Hydrocortisone 1.0%., Inactive Ingredients: Benzyl Alcohol, Bet-Glucanase...Benzyl Alcohol, Beta-Glucanase, Cellulase...
Health FeatureEar CareEar CareEar CareEar CareEar Care
Breed SizeN/ASmall Breeds, Medium Breeds, Large BreedsN/AN/AN/A
Grooming Tool TypeN/AN/AN/A
Packaging TypeN/AN/A

Questions & Answers

56 Customer Questions

Is this safe for cats as well ?
Answer by SuzannaMay 14, 2021

Will the 1.25 ounce bottle be enough to treat 1 dog, both ears?
Answer by ChewyOct 08, 2017
The 1.25 ounce bottle will provide more than 2 weeks worth of daily maintenance to both ears.

how long do you massage the base of your pet's ear and keep the liquid in the ear canal?
Answer by ChewyAug 24, 2018
Massage the base of your pet's ear until the treatment has coated the infected area.

Is this safe if ingested? I have three dogs that like to lick/clean each others ears and want to ensure this is safe.
Answer by ChewyOct 02, 2018
Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use.

ReviewsWrite a Review

Rated 4.8543 out of 5 stars
2189 Reviews
Would recommend to a friend

2189 Customer Reviews

Rated 5 out of 5 stars
By Amanda on May 14, 2022

it really really works!

So in short my dog had a yeast infection in his ears verified but a vet, it cost $300 for the appointment, testing, and then antibiotics and cleaner. The meds they gave me ran out in the week user error probably and they were sapposto last 2 weeks. The infection stayed one of the ears I asked for a refill and they said I had to spend another $300 to get him meds and appointments and testing again. I struggled for months trying to come up with the money. His ear infection became worst that ever. My mom found these meds. I have been using once a day as directed for 7 days and his ear looks healthy I can’t believe it. For all of those pet parents out there who are struggling and my heart goes out to you and I will be buying this for my dog when he get ear infections in the future. This product is a God send. Just remember not to clean their ears the meds work best with the dirt.

Rated 5 out of 5 stars
By blue1 on May 11, 2022

Finally, something works!

Both of my cats had filthy ears, despite a clean check up from the Vet, and frequent cleanings with facial wipes. They had both been on Flea, Tick and Ear mite preventatives, yet their ears were constantly dirty with waxy and brown exudate. My female cat in particular was constantly scratching her ears despite several different ointments and drops. One treatment of the Zymox Ear Treatment worked like MAGIC! now their ears are pink and clean and they are not constantly scratching at their ears!

Rated 5 out of 5 stars
By MaryAnne on May 21, 2022

Cure for ears

After 3 years of taking our dog to the vet and spending thousands, I discovered Zymox at Cheweys and ordered it. Our dog is a poodle, and has never had her ears plucked. The ear problems NEVER stopped until I treated her with Xymox, and she has never scratched or shakes her head since! It’s been about two weeks. None of the vet medicines worked!!!

Rated 5 out of 5 stars
By none on Apr 12, 2022

Relief at last!

Ginger has had problems with one ear all her life; nasty black drainage and terrible iching of the ear all the time. We'd tried everything we could think of to help with that one ear. (The other dogs also tried to help by licking the ear; which didn't help at all) The first day we used the Zymox, suggested by the Chewy vets, she was able to sleep through the night! We used for the 7 days as directed. The ear was no longer red or irritated. It's still draining some brown gunk but she's able to sleep through the night. We're doing a second 7 days to see if we can clear the brown up as well.

Rated 5 out of 5 stars
By Theresaone on Apr 30, 2022

Miserable ear issue

I have an Afghan and noticed she wasn’t herself. Her one ear was red, it wasn’t smelly at all but I could tell it was bothering her. Thought I’d give this a try before going to the vet. 7 days later it was cleared up and all was well. So it was a bit messy as you can’t clean the ear during the 7 days but worth it.

Rated 5 out of 5 stars
By Threehuskies on Apr 6, 2022

Quickly healed the ear

Very quickly made my dogs ear go from angry red (plus scratched up/bloody) to pink and clean. The only thing I don’t like about Zymox is that the oily feeling solution makes dirt stick to the outside of the ears and it takes a week or so before I can get the outside of the ear looking clean again, dirt stuck in fur with Zymox does not clean up easily. But beats spending time and money at the vet when this does the job and the bottle is small enough to take along on trips

Rated 5 out of 5 stars
By Scout on May 3, 2022

Excellent for ear infections!

I’ve been using this product for over 3 years. I have a dog that once in a while gets ear infections. At the first sign of ear scratching I put it in. It’s gone within 3 days. Excellent product has saved me time and vet bills. I highly recommend it. It’s worth every penny. Save $ on auto ship.

Rated 5 out of 5 stars
By Rebecca on May 19, 2022

I think this stuff did the trick!

My dog had a horrible ear problem. Black wax, itchy ears. It wasn’t an infection and the vet and I tried several things. Nothing worked. After a week of this stuff, gone! It’s thick so it stayed put when my dog shook his head.

Rated 5 out of 5 stars
By Patrick on Apr 7, 2022

Best on the market

I have a black lab who will have ear issues (blackish inside and constant scratching) and this is above and beyond the best treatment we have used. It never fails. It can be rather expensive but that is the only con. The fastest relief and ease of application from the bottle engineering is so easy. Would recommend to anyone

Rated 5 out of 5 stars
By Drea on Mar 30, 2022

Cleared my dogs dirty ears

My poor Lilly, she is a Pom mix. She had super dirty. I took her to vet and the vet said no infection and told me to clean her ears.she still had black gunky ears.I read the previous reviews on this product and I was sold. I used the the treatment as indicated for 7 days everyday, and it worked Lilly’s ear cleared out no more gunky ears and no more Itchy ears.