Zymox Ear Infection Solution with .5% Hydrocortisone for Dogs & Cats, 1.25-oz bottle

By Zymox
Rated 4.8593 out of 5 stars
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Zymox Ear Infection Solution with .5% Hydrocortisone for Dogs & Cats, 1.25-oz bottle slide 1 of 7
$22.49Chewy Price
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About This Item

  • Highly effective for aiding in the treatment of bacterial, fungal and yeast infections including Staphylococcus, Pseudomonas, Proteus and Malassezia.
  • Contains three natural bio-active enzymes that when combined, form a powerful antimicrobial defense system that is safe for all ages of cats and dogs.
  • The solution works with the body to react with present pus and debris to kill infectious and antibiotic resistant microorganisms.
  • The non-invasive protocol requires no cleaning before and during use so that the enzyme activity is not disrupted. Hydrocortisone and natural bio-active enzymes, form an antimicrobial defense system in your pet's ears.
  • Made in the USA.
Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsN/AActive Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Benzyl Alcohol, Beta-Glucanase, Cellulase...Deionized Water, Isopropyl Alcohol, Polysorbate 20...Active: Sd-Alcohol 40-2, 10%; Lactic Acid, 1.76%; Benzoic Acid...
Breed SizeN/AN/AN/ASmall Breeds, Medium Breeds, Large BreedsN/A
Health FeatureEar CareEar CareEar CareEar CareEar Care

Questions & Answers

19 Customer Questions

What is the difference between this and the one that has 1% hydrocortisone?
Answer by ChewyFeb 04, 2018
This Solution contains 0.5% Hydrocortisone. The Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Solution has a higher level of hydrocortisone for more serious cases.

Can i use it once a week after treatment to maintain ?
Answer by ChewyOct 17, 2019
Zymox Ear Solution is intended to eradicate a broad range of infections ranging from mild to severe, but many veterinarians have also found Zymox Ear Solution to be effective in maintenance of the ears, especially during the allergy season.

Is this safe to use inside of a dog’s ear?
Answer by ChewyFeb 11, 2019
This was meant to be applied liberally to un-cleaned ear, filling ear canal.

I have german shepards who are shaking their heads and itching even small red bumps. Is this somethingI could use on them? They stay inside most of the time except to go the bathroom. Help
Answer by ChewySep 06, 2017
This Solution is designed to be highly effective for aiding in the treatment of bacterial, fungal and yeast infections including Staphylococcus, Pseudomonas, Proteus and Malassezia. We encourage speaking with your Veterinarian to assist with a diagnosis, for the safest opinion.

ReviewsWrite a Review

Rated 4.8593 out of 5 stars
263 Reviews
Would recommend to a friend

263 Customer Reviews

Rated 5 out of 5 stars
By carol on Jun 5, 2022

wow!!! ear infection GONE

My poor dog has suffered with ear infections for so long :( We kept using the ear wash and drops that the vet gave us and he did not like getting his ear cleaned. His ear was inflamed and red and smelled terrible. Worst of all, he scratched it constantly. Once we used this, the infection cleared in 5 days!!! No more yeast, no more smell, no more scratching, his ear is not inflamed, and best of all he doesn’t mind getting his ear cleaned. I’m so happy I found this product and I would recommend to anyone with a yeasty dog.

Rated 5 out of 5 stars
By Puggle on Jun 1, 2022

chronic ear issues

This stuff is a MUST have. My dog is about 12 now, has had chronic ear issues on one side since she was a puppy. Apparently ear infections run in her breed. After years, this is the only one that has relieved and cleared it up. I only have to use it seasonally as it comes and goes. Seriously, don’t need to spend a ton of money at the vet. Try this first if you have chronic issues as well!

Rated 5 out of 5 stars
By Cloudy on Jun 21, 2022

Great product

My girl was scratching her ears and I had tried a different product that was not helping after receiving this product it stopped the itching immediately and after a week all is great would highly recommend

Rated 5 out of 5 stars
By Cheryl on Apr 19, 2022

Zymox Ear Infection Solution is very effective for ear infections in dogs.

Occasionally, my dog shows signs of his ears bothering him and shakes his head to try to remove the irritation. When he does that, I use the Zymox to remove any debris that may be causing his ear discomfort. Read the directions carefully and follow them and this will take care of it. This has worked for my dogs ear irritation for the past 6 years. I'm sure he appreciates it!

Rated 5 out of 5 stars
By Doppy on Mar 1, 2022

Miracle worker

This stuff is Amazing My Bella had a ear infection, her very first one, and the 1st treatment I noticed way less shaking her head, but the amazing part was treatment 2 It blew me away. I treated her the full 7 days. All Done! Bye bye ear infection. Thanks to chewy for super fast delivery. Thanks CHEWY

Rated 5 out of 5 stars
By KimG on Apr 2, 2022

Great ear yeast product

Our dog has huge floppy ears she is a plott hound she has had ear problems forever the vet gave us drops they didn't help these are amazing in a week she is so much better I highly recommend it!

Rated 5 out of 5 stars
By Rose on Feb 2, 2022

Works for our dog!

One of our dogs has recurrent issues with ear infections and yeast in ears and on feet. She was shaking her head a lot lately so we bought this because of all the positive reviews. Our dog has had meds from the vet for her ear infections but the infection seems to come right back. We did 7 days straight with this med and now doing once a week for maintenance and she hasn’t had an ear infection since! We plan on keeping this in stock always

Rated 5 out of 5 stars
By Jackie on Mar 9, 2022

Ear pain relief

This product has helped my dog from the misery of ear issues. She sleeps better and does not dig in her ear after applying it. Easy to use.

Rated 5 out of 5 stars
By BELLAMAX on Jan 14, 2022


This stuff works! I have a paralyzed little girl who cannot scratch her ears very well since front paws just don't do the job. So she definitely has ear problems. This stuff worked amazingly GREAT! Thank you Chewy for carrying the products I need.

Rated 5 out of 5 stars
By abrummie on Jan 5, 2022


My pup had itchy ears that she had scratched until they were pink and hot. My friend recommended this product and in only 2 applications her ears were normal. I will maintain her ears with this. Wonderful.