ZYMOX Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Infection Solution, 1.25-oz bottle - Chewy.com

Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Infection Solution, 1.25-oz bottle

By Zymox
Rated 4.8131 out of 5 stars

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$33.49Chewy Price
$43.99Chewy Price

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About This Item


  • Naturally occurring enzymes are highly effective against bacterial, fungal and yeast ear infections, plus the anti-inflammatory power of hydrocortisone. While this formula isn’t designed to treat dog and cat ear mites, it could help relieve symptoms and protect against secondary infections from yeast, bacteria, and fungus.
  • Proven antimicrobial LP3 Enzyme System inhibits, splits and destroys the offending organisms while leaving healthy cells alone.
  • Four additional biofilm-reducing enzymes destroy the hard-to-penetrate biofilm slime layer that obscures the microbe.
  • Ideal for cases of repeated infections or infections that won’t resolve, and bacteria will never develop a resistance to the enzymes. Great alternative to antibiotics and the non-toxic solution won’t irritate a pet’s sensitive or irritated skin and is great for dogs and cats.
  • Made in the USA.

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Learn More About Zymox From Our Team of Experts

Questions & Answers

32 Customer Questions

Do I need a vet prescription?
Answer by ChewyOct 02, 2017
This product doesn't require a prescription.

What does “apply liberally” mean exactly ? I.e., how many drops of the solution should I use daily for a large dog ( standard poodle)?
Answer by ChewyMar 26, 2020
It is directed to apply a generously amount of solution to un-cleaned ear, filling ear canal.

Where is this made??? USA????
Answer by ChewySep 06, 2020
This Ear Solution is made in the USA.

Is it safe if ingested Some cats lick their paws and pass it by the ear area ear after using these drops
Answer by ChewyOct 30, 2019
This solution is safe if accidentally ingested.

ReviewsWrite a Review

Rated 4.8131 out of 5 stars
674 Reviews
Would recommend to a friend

674 Customer Reviews

Filter by reviews that mention

Rated 5 out of 5 stars
By Mark on Jan 3, 2023

Best med for itching ears

This is the best product for out 3 American Bulldogs. They get an itch in one ear. We have been to vets and this product works better than RX meds. With out dogs we are never without it on hand.

Rated 3 out of 5 stars
By Vista on Jan 1, 2023

Doesn't help yeast

I used this product for 7 days as per directions. After 7 days there was no improvement at all. Apparently, it doesn't help a yeast infection!!! Buyer beware. Know what you are treating.

Rated 5 out of 5 stars
By Ericsmom on Nov 7, 2022

this stuff really does work

I was afraid to use this because I wasn't sure if my cat would have a bad reaction. he most likely had earmites & an ear infection from the ear mites. I used this once per day for only 3 days & my cat stayed itch free for at least a month & no ear odor at all still long after 1 month. but from what I gather the 1% hydrocortisone is for dogs, the .50 % is safer for cats.

Rated 5 out of 5 stars
By KibasDad on Nov 18, 2022

This stuff is amazing

My little guy has had terrible allergies for most of his life and his ears are always the problem. After a week with this it's like it never happened, his ears are healthy and clean. Will buy again in the future for sure.

Rated 5 out of 5 stars
By Kimm on Sep 30, 2022

Love this product

I waited till I finished the bottle before I would write this review. My Riley keeps getting ear infections- fungal infection which is a hard kind to get under control. When she got another infection in less than four months. I called the vet- who informed me that it would be over a week before they would see us I decided to try this product. So glad I did. My dogs ears look so much better. I am happy when my baby is feeling better

Rated 5 out of 5 stars
By SaraJ on Nov 18, 2022

Great ear product

Our dog was getting a buildup in her ear. While we cleanse them like her Vet said to, this product actually stopped the hills up and took away the itch. It worked very quickly and we are thrilled.

Rated 5 out of 5 stars
By MultiplePetParent on Jan 16, 2023

Zymox Helps With Ear Issues

Helpful to reduce/repair ear inflammation in cats and dogs (all of ours are older than 12 months).

Rated 5 out of 5 stars
By Jessie on Oct 5, 2022

No more ear infections!

This stuff is a lifesaver for my doodle. Her floppy ears get water stuck in them so easily, which leads to yeast infections. The last time we went to the vet, treatment cost a whopping $300. Not wanting to pay that again in a couple of months, I ordered Zymox. I used this at the first sign of irritation (redness, warm to the touch, itching) and overnight her ears look and feel so much better! I have now started using it as a preventative treatment once weekly (or directly after a bath or swim) in order to avoid irritation completely. Puppy has not had a single ear infection since we starting using Zymox, which makes me and my wallet very very happy!

Rated 1 out of 5 stars
By Eileen on Sep 10, 2022

don't waste your money

I used this for my cat's ears and it did NOTHING. I wish I had learned about using coconut oil sooner, my poor cats' ears were itching so badly, he was bleeding from scratching so much. In 2 days, a little organic coconut oil on a q-tip swabbed inside the ear cleared up everything. It's safe, cheaper and more effective than this stuff. I feel guilty I dragged out the poor kitty's suffering and discomfort by not researching about coconut oil sooner.

Rated 5 out of 5 stars
By Jude on Feb 1, 2023

Always on time

As usual great product and customer service Always a pleasure doing business