Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Solution, 1.25-oz bottle

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Treat those stubborn ear infections with the enzymatic power of the Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Solution. Enzymes are naturally occurring proteins that are highly effective against bacterial, fungal and yeast ear infections, so it’s an excellent alternative to antibiotics. Working to destroy the offending organisms, this solution combines the increased potency of the proven antimicrobial LP3 Enzyme System with an additional four biofilm-reducing enzymes. These added enzymes actually penetrate the layer of slime often found in the ear, so ear infections don’t stand a chance. No cleaning of the ear is required so as not to disrupt the enzyme activity, and the inclusion of hydrocortisone provides inflammation relief during the healing process.

Key Benefits

  • Naturally occurring enzymes are highly effective against bacterial, fungal and yeast ear infections, plus the anti-inflammatory power of hydrocortisone.
  • Proven antimicrobial LP3 Enzyme System inhibits, splits and destroys the offending organisms while leaving healthy cells alone.
  • Four additional biofilm-reducing enzymes destroy the hard-to-penetrate biofilm slime layer that obscures the microbe.
  • Ideal for cases of repeated infections or infections that won’t resolve, and bacteria will never develop a resistance to the enzymes.
  • Great alternative to antibiotics and the non-toxic solution won’t irritate a pet’s sensitive or irritated skin and is great for dogs and cats.

Additional Details

Important: Do not clean ears before or during use. Do not use in conjunction with topical ear products or cleaners. Do not allow water in or near ear during use. If condition persists or worsens, discontinue use and consult your veterinarian. Store at room temperature. Warning: Do not use on punctured ear drums. Do not use on pregnant or lactating females. Keep out of reach of children.


Active Ingredient: Hydrocortisone 1.0%

Other Ingredients: Benzyl Alcohol, Bet-Glucanase, Cellulase, Dextranase, Dextrose, D-Mannose, Glucose Oxidase, Glycerine, Hydroxypropyl Cellulose, Lactoferrin, Lactoperoxidase, Lysozyme, Mutanase, Pectinex, Potassium Iodide, Propylene Glycol, Protease, Purified Water.

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    United States


Shake well before use. Apply liberally to un-cleaned ear, filling ear canal. Gently massage and work into infected area. Wipe to remove excess. Use once a day for 7 days. Safe for extended use on persistent cases.

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Powerful Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are also formulated to be safe to use on kittens, puppies and even senior dogs. These solutions pack a potent antiseptic punch that targets the source of infections—bacteria, fungi and yeasts—to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals.

Powerful Antimicrobial and Antifungal Care

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat. To keep furry ones happy, their products treat ear infections, skin allergies, hot spots, bad breath, gum disease and more.

Ear Care Solutions

Ear Care Solutions: Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Oral Care Solutions: Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Skin and Coat Health: Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.



Customer Reviews

81 reviews 81 Reviews 4.8 out of 5 Stars

99% Recommend

99% of reviewersrecommend this product

4.8 / 5

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  • Worked for my pet

    By on

    Went to the vet and was told my dog could possibly have a ear infection or a yeast infection. They gave me this pricy prescription for his ears. I didn't have the money to get it so I went home got online and looked up what I could get to help with the healing of either of the two that the doctor stated he had. This medicine worked. His ears stopped smelling foul and he was no longer in pain. I would definitely recommend this product to someone facing the same thing with their pet. And it wasn't no where near the price of his prescription that the doctor gave me. I love Chewy.com they are the place for all your pet needs. Thanks Chewy.com!! From a faithful buyer

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  • Zymox Plus, 1.0% Hydrocortisone. (((((IT WORKS)))))

    By on

    I wanted to wait to see if the infection came back in Zeus ear after I tried this stuff. I have a 3 year old German Sheppard, ball of love. I bought this stuff and proceeded to give a few drops in his left ear for 2 weeks. I noticed a change almost immediately, probably 7 days. Wax was almost gone and the redness clearing up. He had a lot of brown non smelly wax build up in his ear. I mean a lot...... This stuff cleared up the wax issue 100% with NO manual removal with Q-tips. It disintegrated the wax and healed my boy! It has been about 3 weeks now and his ear is perfect. Looks just like the other healthy one! Kudos to this stuff... All wax is GONE!

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  • saved $ on vet bills

    By on

    My long eared dachshund is very prone to ear infections and I would very often be applying antibiotic drops to them. Between the vet visits and antibiotics, it starts to get a little expensive. Started using Zymox . This stuff works. Gives them immediate relief and helps keep infection away. Now for maintenance I use it about once every two weeks. It keeps their ears clean and healthy so you don't have to go cleaning them with Q-tips and that cleaning stuff.

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  • Finally, something that worked!

    By on

    Our 9 year old GSD suffers from recurring, persistent ear infections. Got this as a last ditch effort before heading to the vet (again). It worked! She was feeling better within one application, less head tilting, less head shaking! After the 2 weeks of treatment she was all better. This is a small bottle but it lasted 2 weeks for our 75 pound GSD while treating both ears for 7 days and the most infected one for 14 days.

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  • Worth every dime

    By on

    Every Rottweiler I have owned has been plagued with ear (yeast) infections and going through the task of cleaning their ears is never a enjoyable task especially for them. This product eliminates all of this plus if there is any discomfort the Hydrocortisone most definitely helps with this. I will recommend this product and wont hesitate to buy it again!!!!

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  • awesome stuff

    By on

    This stuff was amazing. I have been fighting with my dog's ears for 6 months or more.. Tried several different things but nothing worked and he was constantly scratching his ears. SO I did a search again and found this site and this solution.. Oh my goodness.. within three days he had stopped scratching his ears and they look so much better. I did his ears for 7 days. And they are 100% better.

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  • No vet needed. Amazing!

    By on

    Pitbull, about 100 pounds had a nasty ear infection going on. Weird stuff coming out of his ear, and started to smell real bad. Obviously in a lot of pain and discomfort when he slept. I couldn’t afford a vet and this stuff saved my pup and I a trip. Amazing stuff. I hope more people can use this product. I truly cannot thank these guys and girls who made it. Great product and great price. Thanks again!

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  • Great product!

    By on

    Our Bloodhound has had an ear infection all summer and I cleaned her ears every day of crud and changed her diet. Nothing worked until I tried this product. She is now yeast free and no ear infections. I have 2 other dogs that are also prone to them so I use this for them too. Worked in 7 days! I will buy again IF needed!

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  • Zymox ear care

    By on

    Buddy has an ear infection and he has been on Zymox for right at two weeks now. The direction said to put the drops in his ear once a day for seven days. His ear is still red inside and he continues to walk around shaking his head really hard.

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  • Works great

    By on

    I bought this after reading mostly good reviews and it worked great on my dog. His ears had been itching and had a slight odor, I used it on him for 7 days and he barely scratching and the odor is gone. Great product and saved me a bet visit!

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