Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Solution, 1.25-oz bottle
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Treat those stubborn ear infections with the enzymatic power of the Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Solution. Enzymes are naturally occurring proteins that are highly effective against bacterial, fungal and yeast ear infections, so it’s an excellent alternative to antibiotics. Working to destroy the offending organisms, this solution combines the increased potency of the proven antimicrobial LP3 Enzyme System with an additional four biofilm-reducing enzymes. These added enzymes actually penetrate the layer of slime often found in the ear, so ear infections don’t stand a chance. No cleaning of the ear is required so as not to disrupt the enzyme activity, and the inclusion of hydrocortisone provides inflammation relief during the healing process.
Key Benefits- Naturally occurring enzymes are highly effective against bacterial, fungal and yeast ear infections, plus the anti-inflammatory power of hydrocortisone.
- Proven antimicrobial LP3 Enzyme System inhibits, splits and destroys the offending organisms while leaving healthy cells alone.
- Four additional biofilm-reducing enzymes destroy the hard-to-penetrate biofilm slime layer that obscures the microbe.
- Ideal for cases of repeated infections or infections that won’t resolve, and bacteria will never develop a resistance to the enzymes. Great alternative to antibiotics and the non-toxic solution won’t irritate a pet’s sensitive or irritated skin and is great for dogs and cats.
- Made in the USA.
Important: Do not clean ears before or during use. Do not use in conjunction with topical ear products or cleaners. Do not allow water in or near ear during use. If condition persists or worsens, discontinue use and consult your veterinarian. Store at room temperature.
Warning: Do not use on punctured ear drums. Do not use on pregnant or lactating females. Keep out of reach of children.
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Item Number116094
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Product FormLiquid
Active Ingredient: Hydrocortisone 1.0%.
Inactive Ingredients: Benzyl Alcohol, Bet-Glucanase, Cellulase, Dextranase, Dextrose, D-Mannose, Glucose Oxidase, Glycerine, Hydroxypropyl Cellulose, Lactoferrin, Lactoperoxidase, Lysozyme, Mutanase, Pectinex, Potassium Iodide, Propylene Glycol, Protease, Purified Water.
Shake well before use. Apply liberally to un-cleaned ear, filling ear canal. Gently massage and work into infected area. Wipe to remove excess. Use once a day for 7 days. Safe for extended use on persistent cases.

Powerful Antimicrobial and Antifungal Care
ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are also formulated to be safe to use on kittens, puppies and even senior dogs. These solutions pack a potent antiseptic punch that targets the source of infections—bacteria, fungi and yeasts—to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals.

Committed to Healthy Ears, Skin and Coat, and Smiles
To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat. To keep furry ones happy, their products treat ear infections, skin allergies, hot spots, bad breath, gum disease and more.

Ear Care Solutions: Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions: Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health: Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.
100% Safe, Gentle and Easy
Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free
Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.
About ZYMOX
Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

Customer Reviews
99% Recommend
99% of reviewersrecommend this product
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A vet bill saver!!!
By MeekaPit on Jan 29, 2021
My pit is a swimmer and constant yeast infections. I started using zymox otic 1 percent hydrocortisone 10 years ago! I was taking my dog to the vet monthly for yeast infections because she is a swimmer and even after a bath or a travel long ride in the car. I haven’t needed to take her for an ear infection not once since I started using this product. After I got the yeast infection in control I started using this after swimming and after giving her a bath and she has never needed to go go to the veterinarian again for an ear infection. So although it’s an expensive little bottle it’s a lot cheaper then going to the vets office on a monthly basis. The 1 percent hydrocortisone is much better then My pit is a swimmer and constant yeast infections. I started using zymox otic 1 percent hydrocortisone 10 years ago! I was taking my dog to the vet monthly for yeast infections because she is a swimmer and even after a bath or a travel long ride in the car. I haven’t needed to take her for an ear infection not once since I started using this product. After I got the yeast infection in control I started using this after swimming and after giving her a bath and she has never needed to go go to the veterinarian again for an ear infection. So although it’s an expensive little bottle it’s a lot cheaper then going to the vets office on a monthly basis. The 1 percent hydrocortisone is much better then the .5 for the itchy if yeast infections. Highly recommend for those who have dogs with chronic yeast infections due to swimming or bathing. It keeps my dogs ears spotless. Oh... also... do not clean dogs ear first this works with the bad bacteria. And fill the ear canal and gently rub ears and wipe excess before the dogs shakes their head. Veterinarian free for 10 years for ear infection. … more
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Good product!
By Carrie on Feb 14, 2021
About a month ago my Golden-Marley started doing the head shake- I looked in his ears and found one with smelly brownish red waxlike goo and referred to Chewy & read many positive reviews of this product line. I ordered it(Zymox Plus Advanced) and used it once a day for 2 weeks and his ear no longer has the wax like goo in it. He also stopped the shaking of his head and seems much more himself.
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Seems to have helped
By OneEyedPetesDaddy on Jan 12, 2021
Our pal One-Eyed-Pete the Maine Coon Cat adopted us about a year and a half ago when he was probably 6-12 mo old. Blind in one eye, 7.5 # and already neutered, he’d been living off the land after being abandoned. He’s now about 11 pounds. Healthy in all respects besides itchy ears and skunky breath from day one. No visible debris in the ears so I was confident not an ear mites problem. I Figured it was a fungal or bacterial infection. We tried the regular Zymox first, completing the recommended seven day therapy without much success. Upgraded to the Zymox Plus and once again did the seven day therapy. This time we have made progress. That was completed several weeks ago, and his ears are probably Our pal One-Eyed-Pete the Maine Coon Cat adopted us about a year and a half ago when he was probably 6-12 mo old. Blind in one eye, 7.5 # and already neutered, he’d been living off the land after being abandoned. He’s now about 11 pounds. Healthy in all respects besides itchy ears and skunky breath from day one. No visible debris in the ears so I was confident not an ear mites problem. I Figured it was a fungal or bacterial infection. We tried the regular Zymox first, completing the recommended seven day therapy without much success. Upgraded to the Zymox Plus and once again did the seven day therapy. This time we have made progress. That was completed several weeks ago, and his ears are probably 70-80% less itchy. His breath is better but still Nastier smelling than any cat I have ever had. I suspect the ears and the breath are connected. Wish we had started with the Plus. It is more expensive but it lists more enzymes and therefore I suspect it covers a broader range of infections. Maybe a follow up treatment will finish knocking this out. … more
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This stuff WORKS
By Bethy on Jan 16, 2021
My 2 year old cocker spaniel is prone to itchy smelly ears. They’re never infected, just gross with icky brown gunk in them and he scratches all day. Id clean his ears and that would make it worse. One application of this and his ears were 95% better the next day. His ears look normal and were clean instead of dark pink and smelly. I couldn’t believe it. I had previously bought the regular zymox because it was cheaper and it kinda worked but if you have a dog w/ ear problems like I do it is definitely worth the extra money for the zymox plus. He is like a different dog now. Very happy dog mom here!
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I highly recommend this!
By DawnS on Jan 5, 2021
We have two hounds. One of them has had more ear infections than all our other dogs combined. When we rescued him he had to have a wrap around his head so his ear could heal from scratching. Sometimes I've cleaned his ears almost daily, and he was still creating that black gunk every day (not an infection, but waxy stuff in his ears), and then the vet said that was too often. But if I ever let it go a couple of weeks (like on vacation or whatever), back to the vet we would go (you know, odor, the sound of fluid in his ear, discomfort). THIS AWESOME solution stopped that! Not only did it combat an infection without a vet visit, it somehow restored balance in his ears! I clean his ears once We have two hounds. One of them has had more ear infections than all our other dogs combined. When we rescued him he had to have a wrap around his head so his ear could heal from scratching. Sometimes I've cleaned his ears almost daily, and he was still creating that black gunk every day (not an infection, but waxy stuff in his ears), and then the vet said that was too often. But if I ever let it go a couple of weeks (like on vacation or whatever), back to the vet we would go (you know, odor, the sound of fluid in his ear, discomfort). THIS AWESOME solution stopped that! Not only did it combat an infection without a vet visit, it somehow restored balance in his ears! I clean his ears once or twice a week, and he has barely any black gunk at all! If I could underline that sentence about restoring balance for him, I would, it has been that life changing around here. … more
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Zymox plus
By Kathy on Jan 14, 2021
My cat had a ear infection took to vets and two weeks later it’s back, the doctor gave me medication to use again cause taking my cat is so stressful for her. Well two week later it’s back and the black stuff in the ear never went away. So I ordered Zymox I was a little scared to use it, but it worked, I only used it three times in her one ear and it looks amazing!!!!! No more black stuff in it and she isn’t scratching it or shaking her head anymore!! I highly recommend it.
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2 days in and already working so well
By impressed on Feb 10, 2021
Can’t believe how quickly this has started working. My pitbull had one ear that kept getting scaly, gross, and super red. We’re only two days in and it already looks SO much better and he has stopped scratching. Resist the urge to clean your dogs ears while using this - if you follow the instructions it really seems to work.
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chronic ear infections be gone
By Jazz on Dec 24, 2020
What an awesome product! We adopted a huge pittie with cropped ears earlier this year. We took her in without knowing of all the allergies and problems that came along with her. She’s such a sweetheart, that we did everything we could to make her comfy and well! A couple of months in, we noticed she was shaking her ears quite a bit, nasty brown gunk and as coming out, and she was scratching at her ears relentlessly that she would scratch until they bled and she had to basically live in a cone. Poor girl. When we first took her to the vet, they wanted us to do a monthly medicine for her ear that would have cost $150+ PER MONTH. Yea, along with her other allergies and problems we were trying to What an awesome product! We adopted a huge pittie with cropped ears earlier this year. We took her in without knowing of all the allergies and problems that came along with her. She’s such a sweetheart, that we did everything we could to make her comfy and well! A couple of months in, we noticed she was shaking her ears quite a bit, nasty brown gunk and as coming out, and she was scratching at her ears relentlessly that she would scratch until they bled and she had to basically live in a cone. Poor girl. When we first took her to the vet, they wanted us to do a monthly medicine for her ear that would have cost $150+ PER MONTH. Yea, along with her other allergies and problems we were trying to figure out, that adds up quickly. I stumbled upon this amazing product. Applied it for 7 days straight and saw INSTANT relief. A month later, her ears are golden! … more
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Easy to use/really works
By Ripley on Feb 20, 2021
We’ve tried several different canine ear solutions for our Great Pyrenees. She tolerates this one well (the others required 3 people to apply them) I can apply this one by myself and it cleared the ear infection within 4-6 days.
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Perfect product
By Sheila on Jan 11, 2021
My cat keeps getting dermatitis and the vet keeps giving her antibiotics because she itched herself so bad she had open sores but never bothered to try a steroid for the actual problem which turned out to be a food allergy. So I tried this after changing her wet food and she hasn't scratched her ears one time since the initial dose. So happy that she is happy and most of all healthy again.