Zymox Topical Cream Inflammation Relief Hydrocortisone 1.0% for Dogs & Cats

By Zymox
Rated 4.4778 out of 5 stars
$13.99Chewy Price
$17.99Chewy Price
In Stock
FREE 1-3 day delivery on first-time orders over $35

About This Item


  • Provides a powerful natural enzyme formula to aid in the treatment of topical skin infections, wounds and cuts.
  • An antibiotic alternative for the broad spectrum management of wounds and skin infections such as atopic dermatitis, skin fold pyoderma, acute moist pyoderma, ringworm, hot spots, and anal sac abscesses.
  • Aids in the treatment of infections due to bacteria, fungus and viruses and yeast. The addition of 1% Hydrocortisone helps to provide relief from itching and inflammation.
  • No need to pre-clean or disinfect area because the patented LP3 Enzyme System reacts with the exudate, infectious pus or debris to form its antimicrobial properties.
  • Made in the USA.

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Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

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Total Price: $62.47

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsActive Ingredient: Hydrocortisone 1.0%., Inactive Ingredients: Aloe Vera, Benzyl Alcohol...Hydrocortisone 0.5%, Glyceryl Polymethacrylate, Glycerin...Benzoic Acid, Malic Acid, Salicylic Acid.Active Ingredients: Benzalkonium Chloride 0.15%. Inactive Ingredients: Water, Mineral Oil, Glyceryl Stearate SE...1% Hydrocortisone acetate.
Breed SizeExtra Small Breeds, Small Breeds, Medium Breeds...Small Breeds, Medium Breeds, Large Breeds, All BreedsAll Breeds
Health FeatureFirst Aid, Skin & Coat HealthFirst Aid, Skin & Coat HealthSkin & Coat HealthSkin & Coat Health
LifestageAdultAdultAdultAll LifestagesAdult

Questions & Answers

22 Customer Questions

My dog has been biting and licking underneath his tail near the anal area - is this safe to use to provide some relief?
Answer by ChewyMay 19, 2018
This Topical Cream can be used to treat the external anal area.

Can it be applied to my dog's paws?
Answer by ChewyDec 19, 2018
This product can be used on your dog's paws for itch relief.

Will this particular product help with mange or hair loss?
Answer by ChewyApr 20, 2018
This product isn't intended to treat mange or reverse hair loss. We recommend consulting a veterinary professional for the best for of treatment.

Can you use this for ring worm?
Answer by ChewyNov 03, 2017
This Cream is an antibiotic alternative for the broad spectrum management of wounds and skin infections such as atopic dermatitis, skin fold pyoderma, acute moist pyoderma, ringworm, hot spots, and anal sac abscesses.

ReviewsWrite a Review

Rated 4.4778 out of 5 stars
90 Ratings
Would recommend to a friend

90 Customer Reviews

Rated 5 out of 5 stars
By Kath on Jul 31, 2023

zymox cream

Worked great on raw elbows. Bo’s happier and in Less discomfort. THANXX, Chewy staff for the special best for our Bo. We’re not sure how long Bo has left with us but we’re making every effort to keep him as healthy as possible.

Rated 4 out of 5 stars
By Liz56 on Apr 27, 2023

It works on Rose!

Iv used this cream for a few years now and it does work from ringworms to skin sores due to a flea breakouts. It is soothing as soon as I rub it in and my cats don’t mind it. I always make sure I have this on-hand because I have 9 cats and I never know when I’m going to need it.

Rated 5 out of 5 stars
By Krisjohn78 on Mar 13, 2023

Zymox Ointment

This stuff is amazing. I have tried everything to heal my new puppies ears and this stuff has them almost completely healed already.

Rated 4 out of 5 stars
By Peanut on Nov 3, 2022

Not as good as the spray

I use this when my cat with allergies gets sores on his face. It works but not as quickly as the spray. He also wipes this off, he can't really wipe the spray off...but I can't spray his face so we use this on facial scabs and sores.

Rated 5 out of 5 stars
By Michelle on May 9, 2022

Bald belly

Works pretty good Helped take the itch away . He's hard to medicate so I've not medicated him religiously it's very hard but definitely helped because it's not red like before . No prescriptions involved

Rated 3 out of 5 stars
By Denise on Apr 13, 2022

Not what I thought

I thought my girl would stay still and I could put this on her to relive her from some of the rawness on her tail. But, she wasnt having any of it. I guess it burned her raw tail she boot scooted herself right along to get it off.

Rated 5 out of 5 stars
By HotSpot on Feb 27, 2022

It works for Hot Spot

This is the only thing that helped our cat with hot spots. Our cat is entirely a different cat after the hot spots are healed up.

Rated 5 out of 5 stars
By BoxerMom on Feb 14, 2022

Boxer Approved

This product helped with a hot spot on our Boxer's left hip. I recommended the product to a friend and let her use some on her Pointer.

Rated 5 out of 5 stars
By Renaenae on Nov 12, 2021


My dog has seasonal allergies and this year was horrible. Not only was he licking his paws, but also his legs to the point that they were bleeding. I had to watch him like a hawk to keep him from licking, but then I noticed his paws were super dry and flaky and then the whole process would restart. After just one day of using this product (2 applications) I noticed a difference. From day 2 I only did one application a day and his feet looked completely back to normal by the 3rd day. The cream is a perfect consistency, slight gel/slight lotion and the aloe gives it a nice smell. I cannot recommend this enough.

Rated 5 out of 5 stars
By Jenn on Sep 24, 2021

itchy allergy relief!

My 2 year old yorkie/bichon mix has really bad allergies that cause her to itch and bite at her back legs until she pulls all the hair out and irritates her skin raw. She’s been to the vet for it a lot (apoquel, steroids, shampoos, cytopoint). She’s currently not on any medication, but had a flare up. I put this ointment on the affected area twice a day while also either having her wear a cone or pajamas as to not bother it. After about a week her skin looks SO much better and isn’t itchy. I’ll definitely be keeping this on hand for future flare ups!!