Zymox Topical Cream Inflammation Relief Hydrocortisone 1.0% for Dogs & Cats

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About This Item

Details

  • Provides a powerful natural enzyme formula to aid in the treatment of topical skin infections, wounds and cuts.
  • An antibiotic alternative for the broad spectrum management of wounds and skin infections such as atopic dermatitis, skin fold pyoderma, acute moist pyoderma, ringworm, hot spots, and anal sac abscesses.
  • Aids in the treatment of infections due to bacteria, fungus and viruses and yeast. The addition of 1% Hydrocortisone helps to provide relief from itching and inflammation.
  • No need to pre-clean or disinfect area because the patented LP3 Enzyme System reacts with the exudate, infectious pus or debris to form its antimicrobial properties.
  • Made in the USA.

Ingredient Information

Instructions

Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.

About ZYMOX

Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.
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Questions & Answers

21 Customer Questions


My dog has been biting and licking underneath his tail near the anal area - is this safe to use to provide some relief?

Answer by ChewyMay 19, 2018
This Topical Cream can be used to treat the external anal area.

Can it be applied to my dog's paws?

Answer by ChewyDec 19, 2018
This product can be used on your dog's paws for itch relief.

Will this particular product help with mange or hair loss?

Answer by ChewyApr 20, 2018
This product isn't intended to treat mange or reverse hair loss. We recommend consulting a veterinary professional for the best for of treatment.

Can you use this cream longer than 2 weeks?

Answer by ChewySep 16, 2020
The manufacturer recommends applying this topical cream to the affected area once daily or as needed for one to two weeks. If you'd like to use it for more than two weeks we recommend consulting your veterinarian for the best course of action.

4.5
Rated 4.5 out of 5 stars
283 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Active Ingredients

83% Positive

Ease of Use

92% Positive

Effectiveness

86% Positive

Non-Toxic and Safe

85% Positive

140 Customer Reviews



Rated 5 out of 5 stars
By Lisa on Nov 6, 2025

Helping itchy skin

It worked but I had allot of trouble putting it on his itchy spots he was so miserable he would not let me touch him. I guess I should of tried the spray.

It worked but I had allot of trouble putting it on his itchy spots he was so miserable he would not let me touch him. I guess I should of tried the spray.


Rated 2 out of 5 stars
By Barbara on Jan 13, 2026

It is very solid not easy to put on my cat.

Not sure it did any good but the cat runs every time I try to use it on him.

Not sure it did any good but the cat runs every time I try to use it on him.


Rated 5 out of 5 stars
By Jane on Aug 8, 2025

Worked very quickly & effectively

One of our dogs developed several hot spots, which we treated with another product that was working - but SO slowly. A pharmacist friend suggested something with

One of our dogs developed several hot spots, which we treated with another product that was working - but SO slowly. A pharmacist friend suggested something with 1% hydrocortisone, so after some research, I decided to order this. Not only does it work quickly, but the dog does not try to lick it off (which he did with the other product). The hot spots are fading and we all are relieved!


Rated 2 out of 5 stars
By Suzy on Aug 18, 2025

Zymox

Did not work for itching inflammation for my dogs paw that had a kerotonosis type growth my vet had to dig a portion from and send out for biopsy. She was concerned

Did not work for itching inflammation for my dogs paw that had a kerotonosis type growth my vet had to dig a portion from and send out for biopsy. She was concerned it was mast cell tumor. It thankfully was not, it was a very hard round cyst type keratonosis . Arnica worked, the Zymox cream did not.


Rated 5 out of 5 stars
By Barbara on Aug 28, 2025

Easy to Use

This form of Zymox is easy to use and works with skin irritations and hot spots and there is enough in the tube to last a while. My pup doesn't like the spray and

This form of Zymox is easy to use and works with skin irritations and hot spots and there is enough in the tube to last a while. My pup doesn't like the spray and some other forms don't last. Zymox is definitely a good topical cream


Rated 1 out of 5 stars
By Paola on Aug 29, 2025

Did not work for my cat

I wanted to try something new for my cat’s dry scaley wounds. She chews on her skin like crazy when she gets a flea bite. Coconut oil moisturized it better and I’ve

I wanted to try something new for my cat’s dry scaley wounds. She chews on her skin like crazy when she gets a flea bite. Coconut oil moisturized it better and I’ve used another product that has shown results overnight.


Rated 5 out of 5 stars
By Deanna on Oct 8, 2025

Absorbing, odorless, worked, not greasy.

I have no idea why my retrievers paws itch so bad. This seems to work well. Needs a good 5 to 10 minutes to work its best.

I have no idea why my retrievers paws itch so bad. This seems to work well. Needs a good 5 to 10 minutes to work its best.


Rated 3 out of 5 stars
By Kathleen on Aug 10, 2025

OTC not strong enough; BC ok with it otherwise

Consistency very good, not as thick as other creams which BC hates. He tolerated application well and licked it from his paws (safe). His condition (per our vet)

Consistency very good, not as thick as other creams which BC hates. He tolerated application well and licked it from his paws (safe). His condition (per our vet) requires a stronger dose).


Rated 4 out of 5 stars
By Estalita on Nov 14, 2025

Stop the itch

When applied Dexter immediately stop scratching the area.

When applied Dexter immediately stop scratching the area.


Rated 5 out of 5 stars
By Judy on Oct 2, 2025

Hank's toe.

Hank has had a sore between his two toes and this cream healed it.

Hank has had a sore between his two toes and this cream healed it.