Zymox Enzymatic Topical Spray with Hydrocortisone for Dogs & Cats, slide 1 of 1

Zymox Enzymatic Topical Spray with Hydrocortisone 0.5% for Dogs & Cats, 2-oz bottle

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The most common skin condition both dogs and cats can be afflicted with are hot spots. They are characterized by itchy, raw, sometimes bloody patches of skin. This Zymox Enzymatic Topical Spray with Hydrocortisone helps manage hot spots and is also ideal for wound care and other common skin infections.

Key Benefits
  • Gentle, enzymatic approach to first aid care for wounds, cuts, hot spots and even mild skin infections. It's so gentle, it's even suitable for kittens and puppies!
  • Contains hydrocortisone for inflammation and itch relief.
  • No pre-cleaning or scrubbing of the area before use.
  • LP3 Enzyme System reacts with the infectious pus and debris to form its antimicrobial properties.
  • Made in the USA.

With products containing hydrocortisone, do not use on pregnant or lactating females. Avoid contact with eyes. Stop use and consult your veterinarian if condition worsens, or rash or other allergic reaction develops. Keep out of reach of children. Store at room temperature.

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Hydrocortisone 0.5%, Aloe Vera, Benzoic Acid, Benzyl Alcohol, Dipropylene Glycol, Glucose Oxidase, Glycerin, Isopropyl Myristate, Lactoferrin, Lactoperoxidase, Lysozyme, Potassium Iodide, Propylene Glycol, Purifi Ed Water, Sodium Benzoate, Tripropylene Glycol, Zinc Gluconate.


Shake well before use. Hold bottle 4 - 6" away from affected area and apply until thoroughly covered. Apply once daily for one to two weeks. May be lightly covered with sterile bandage.

Powerful Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are also formulated to be safe to use on kittens, puppies and even senior dogs. These solutions pack a potent antiseptic punch that targets the source of infections—bacteria, fungi and yeasts—to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals.

Powerful Antimicrobial and Antifungal Care

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat. To keep furry ones happy, their products treat ear infections, skin allergies, hot spots, bad breath, gum disease and more.

Ear Care Solutions

Ear Care Solutions: Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Oral Care Solutions: Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Skin and Coat Health: Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.


Rating: 4.6 of 5 stars 46 Reviews 46 Reviews 4.7 out of 5 Stars

96% Recommend

96% of reviewersrecommend this product

Rating: 4.6 of 5 stars 4.7 / 5

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46 Reviews

Showing 1-10 of 46 Reviews

  • 3 out of 5 stars

    Turns white fur yellow! Unsure if it works.

    By bellamaxi1 on Oct 8, 2021

    After using this as directed a couple of times on my small terrier mix, I noticed her fur turned yellow where applied. I am not sure if it is actually working but will monitor a hot spot closely.

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  • 1 out of 5 stars

    Wish I knew how the actual product works.

    By GoodKarmaCats on Aug 14, 2021

    Unfortunately, this product arrived in a plastic bag which is virtually unopenable due to having leaked during transit. While I appreciate that it was put in a plastic bag, the sensible thing to do would be to tighten the lid to minimise the likelihood that it would leak. I rescue cats who often have itchy, raw spots from flea bites and I was really hopeful this product would work for them.

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  • 5 out of 5 stars

    WOW! What a great product!

    By Pixie on Jun 2, 2021

    My furbaby, Taffie, Has been on medication for her skin issues for several years now. I stopped using the medication and ordered this product. I am amazed - after using for a few days, the issues have all but gone away - her skin is healthier than it's been in a long time. Awesome product!

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  • 5 out of 5 stars

    This product actually worked!

    By Cindy on Mar 29, 2021

    My miniature schnauzer seems to suffer from a troublesome spot on her neck every time I get her groomed. She starts scratching that one particular spot causing it to bleed sometimes. I tried another product in the past, but it did not work. After reading the reviews for Zymox I thought I'd give it a try. Within a day, she didn't scratch as much; and after about two days, the Zymox definitely was effective in helping eliminate the problem.

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  • 5 out of 5 stars

    Live this product!

    By LizC on Mar 4, 2021

    I definitely recommend this product! My cat's scratching this winter was getting so bad his while back was scabbed up and he was miserable! The mixture of this and putting salmon oil in his food has his whole back cleared up in a week!!!

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  • 5 out of 5 stars

    Good Stuff

    By Yummy on Mar 29, 2021

    Good Stuff. You will not be disappointed - see an improvement in about 4 days. Good stuff. it does have a steroid in it, so make sure applying to the correct type of need

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  • 5 out of 5 stars

    ear spray for dogs

    By DeeDee on Mar 4, 2021

    This works great on my basset's ears. When he starts shaking his head a lot we spray this in his ears. It helps him immediately.

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  • 5 out of 5 stars

    Itchy paws dog

    By Chelle on Mar 27, 2021

    Excellent for tuckers paw. Was red and irritated. Healed quickly

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  • 5 out of 5 stars

    Zymox is really great stuff !

    By Zymox on Aug 28, 2020

    The underside of our rat terrier had been itchy and red for a long time. She would scratch it a lot and it never seemed to get better. We used regular hydrocortisone cream and that helped some, but it would never heal completely and it would be red and itchy again in a few days. After we started using Zymox Enzymatic Topical Spray, the results were immediate. We only had to use Zymox for 4 or 5 days, with one later application. The skin on her belly has now cleared up and is soft to the touch and does not itch. She no longer scratches. We think Zymox is great!

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  • 5 out of 5 stars

    immediate relief

    By KellyG on Aug 19, 2020

    Our boxer has skin allergies that escalate so quickly that they get blistered, infected and ooze. It's terrible and so itchy and painful for him. We use this (in combination with Zymox shampoo & conditioner and skin ointment) and he literally feels IMMEDIATE relief. I spray AM & PM for a few days when it flares up and he quits licking (which means they can heal!!!) He hates the spray, but it's worth it for the relief he feels. It smells pleasant and isn't overwhelming.

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