Zymox Enzymatic Topical Spray with Hydrocortisone 0.5% for Dogs & Cats, 2-oz bottle

By Zymox
Rated 4.6346 out of 5 stars
$13.99Chewy Price
$17.99Chewy Price

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This Item – Zymox Enzymatic Topical Spray with Hydrocortisone 0.5% for Dogs & Cats, 2-oz bottle
Rated 4.6346 out of 5 stars
$13.99Chewy Price

Spend $100, Get $30 eGift Card with code: FALL

Zymox Veterinary Strength Dog & Cat Ear Cleanser, 4-oz bottle
Rated 4.4338 out of 5 stars
$12.99Chewy Price

Spend $100, Get $30 eGift Card with code: FALL

Total Price: $39.97

About This Item


  • Gentle, enzymatic approach to first aid care for wounds, cuts, hot spots and even mild skin infections. It's so gentle, it's even suitable for kittens and puppies!
  • Contains hydrocortisone for inflammation and itch relief.
  • No pre-cleaning or scrubbing of the area before use.
  • LP3 Enzyme System reacts with the infectious pus and debris to form its antimicrobial properties.
  • Made in the USA.

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Top IngredientsHydrocortisone 0.5%, Aloe Vera, Benzoic Acid...Active Ingredients: Hydrocortisone 1.0%., Inactive Ingredients: Aloe Vera, Benzoic Acid...Active: Hydrocortisone 1%, Pramoxine Hydrochloride 0.5%, Inactive: Propylene Glycol...N-Alkyl (50% C14, 40% C12, 10% C16)...Oatmeal Protein, Tea Tree Oil, Distilled Witch Hazel...
Health FeatureItch & Redness Remedy, Skin & Coat HealthItch & Redness Remedy, Skin & Coat HealthAllergy ReliefSkin & Coat HealthItch & Redness Remedy, Skin & Coat Health
LifestageAdultAdultAdultAdultPuppy, Adult
Breed SizeSmall Breeds, Medium Breeds, Large Breeds

Questions & Answers

7 Customer Questions

can this product be used for ear infections on my dog?
Answer by ChewyJun 16, 2018
This product is formulated for wounds, cuts, hot spots and even mild skin infections, however, it is not recommended to be used for ear infections.

Will this make my cat sick if they lick the affected area after applying this product?
Answer by ChewyAug 11, 2018
While licking this spray wont cause sickness, you should prevent the pet from licking to allow it to dry.

Is this safe to use on a female dogs private areas?
Answer by ChewyDec 12, 2019
We recommend testing a small area to ensure your pet doesn't have an adverse reaction. This spray does contain alcohol, the Zymox Enzymatic Topical Cream with Hydrocortisone 0.5% for Dogs & Cats may be more suitable.

Can this be used long term on a cat with environmental allergies?
Answer by ChewyMay 13, 2020
It is recommended to use topical spray once daily up to 7 days. If condition persists or worsens for more than 7 days, stop use and consult a veterinarian.

ReviewsWrite a Review

Rated 4.6346 out of 5 stars
52 Ratings
Would recommend to a friend

52 Customer Reviews

Rated 5 out of 5 stars
By Doxadore on Sep 15, 2023

Relieves itching

I was desperate to find something to help my 8 year old long haired dachshund who has been scratching himself due to allergies. This spray gets him through the day and I am so grateful for this product.

Rated 5 out of 5 stars
By Cheyenne on Jan 18, 2023

Amazing product for my cats!

I 100% recommend this product. My girl kitty had scabs on her ear and itched them to the point it made her growl.. I then saw this and when my husband bought it I used it right away on her, within a week it was getting healthier and by the second it was gone! Now my boy kitty who's getting neutered today has it and I've been using this for almost a week now on him, I've noticed he's been barely itching the scabs so I'm pretty sure it is working! Tho when I sprayed it on his ears the first few times... He tried to run away lol! Now that it's been 4-5 days he won't run away anymore. I posted what his ears look like 2 days ago, they're getting a lot better now than what this photo looks, I'll update later!

Rated 5 out of 5 stars
By Elia on Jun 29, 2023

Improved skin condition and relief from itching.

Rated 1 out of 5 stars
By SamG on Dec 21, 2022

Bad results for my cat

My older cat has been having some skin issues lately. Itching and licking himself raw. He is an indoor only cat. I tried this spray hoping it might relieve his itching. Instead it made him sick. He became listless and drooled heavily for several days. His skin issue got significantly worse. Maybe this spray works for some animals, for some issues. But it definitely did not work out for my old guy.

Rated 5 out of 5 stars
By Sadie on Aug 4, 2022

What a relief!

My doxi mix has horrible skin allergies and every Summer she scratches herself raw. Even the Cytopoint injections only lasted a couple of weeks. I’ve used this on her twice and both times she’s stopped scratching for a few days each time. I started using the shampoo & conditioner once a week with this spray mid-week and she is much more comfortable.

Rated 4 out of 5 stars
By Heather on Jul 26, 2022
Top 1000 Contibutor

Works well

I purchased this product to help with hot spots. The cortisone in it really helps with the itching. It helped dry it up too.

Rated 3 out of 5 stars
By bellamax on Oct 8, 2021

Turns white fur yellow! Unsure if it works.

After using this as directed a couple of times on my small terrier mix, I noticed her fur turned yellow where applied. I am not sure if it is actually working but will monitor a hot spot closely.

Rated 1 out of 5 stars
By GoodKarmaCats on Aug 14, 2021

Wish I knew how the actual product works.

Unfortunately, this product arrived in a plastic bag which is virtually unopenable due to having leaked during transit. While I appreciate that it was put in a plastic bag, the sensible thing to do would be to tighten the lid to minimise the likelihood that it would leak. I rescue cats who often have itchy, raw spots from flea bites and I was really hopeful this product would work for them.

Rated 5 out of 5 stars
By Pixie on Jun 2, 2021

WOW! What a great product!

My furbaby, Taffie, Has been on medication for her skin issues for several years now. I stopped using the medication and ordered this product. I am amazed - after using for a few days, the issues have all but gone away - her skin is healthier than it's been in a long time. Awesome product!

Rated 5 out of 5 stars
By Cindy on Mar 29, 2021

This product actually worked!

My miniature schnauzer seems to suffer from a troublesome spot on her neck every time I get her groomed. She starts scratching that one particular spot causing it to bleed sometimes. I tried another product in the past, but it did not work. After reading the reviews for Zymox I thought I'd give it a try. Within a day, she didn't scratch as much; and after about two days, the Zymox definitely was effective in helping eliminate the problem.