Zymox Topical Dog & Cat Enzymatic Skin Cream, 1-fl oz tube

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About This Item

At a Glance

  • Skin & Coat Health
  • All Lifestages
  • All Breeds

Details

  • Provides gentle, soothing relief from skin irritations like itchy skin, hot spots, dermatitis and more.
  • Soothing ointment helps manage painful skin issues without using harsh chemicals or alcohol.
  • No pre-cleaning is required, making applications less painful.
  • Paw-fect for dogs and cats of all ages, ZYMOX Topical Cream is made with gentle ingredients that are safe if licked after application.
  • Veterinarian-strength pet formula is ideal for skin irritations to the face, paws and body folds.

Ingredients

Instructions

Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.

About ZYMOX

Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.
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Questions & Answers

16 Customer Questions

can it be used on warts

Answer by Chewy • Apr 16, 2022
This cream can help relieve red, inflamed skin and is effective against bacteria, fungus and yeast.

Is this good for skin fold rashes?

Answer by Chewy • Feb 18, 2022
This cream is suitable for use with hot spots, body fold irritations, wounds, cuts, and skin infections due to bacteria, fungus or yeast plus ringworm, staph and MRSA.

Can this be used around the vulva?

Answer by Chewy • May 16, 2021
When applying this product eyes and mucous membranes should be avoided.

Can this be used in a dogs ears for yeast infection?

Answer by Chewy • Jun 06, 2024
This cream is not intended for use on ears.
Reviews
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4.3
Rated 4.3 out of 5 stars
327 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

92% Positive

Effectiveness

87% Positive

Ingredients

83% Positive

Long-Term Benefits

85% Positive

154 Customer Reviews

Rated 3 out of 5 stars
By Carol on Jan 9, 2026

Gentle cream

Hoping it’s soothing my cat’s dermatitis. Have been using for 2 weeks. Haven’t seen any difference. Snout + ears have no fur, + whiskers are missing on 1 side.

Hoping it’s soothing my cat’s dermatitis. Have been using for 2 weeks. Haven’t seen any difference. Snout + ears have no fur, + whiskers are missing on 1 side. ;(

Rated 1 out of 5 stars
By Patrick on Nov 9, 2025

Not as advertised.

The add states that this can be used topically, and is safe for dogs should they lick it. When you get the item and read the warnings. It's VERY clear that it is

The add states that this can be used topically, and is safe for dogs should they lick it. When you get the item and read the warnings. It's VERY clear that it is NOT to make contact with the mucus membrane, OR the eyes. I paid through the nose for this little tube, and I can use it to relieve my poor dogs itching. I'm VERY disappointed.

Rated 4 out of 5 stars
By Jenny on Aug 17, 2025
Top 1 Contributor

Works great but cat likes to lick it

My white pittie mix has more allergies and skin issues than I can count, so I've ended up buying almost the entire line of Zymox treatments. I first bought the

My white pittie mix has more allergies and skin issues than I can count, so I've ended up buying almost the entire line of Zymox treatments. I first bought the shampoo/conditioner as a last-ditch attempt to help her horribly itchy skin after a bad reaction to hip & joint supplements and it worked wonders. Then the ear wipes to try to keep her itchy ears under control, which also work great. She gets irritated flaky patches (from allergies / bug bites) on the tops/folds of her ears where she has scars, and also gets red spots on her stomach if she lays in the grass when I'm not looking, so I got a tube of this cream to see if it would help. It's easy to apply, doesn't take much to work in to the skin so the tube lasts a long time even though it's small, and doesn't leave grease or a weird smell like other ointments. It does help clear up her minor skin issues, but it turns the poor dog into a popsicle for my cat! There's something in it that's like candy to the cat, even when I make sure to massage it well into her skin. The cat follows the dog around and tries to lick her ears whenever she lays down, even standing on hind legs to try to reach her ears if the dog stands still long enough. I have to discourage the cat, or put the cream on right before we're going for a walk or to bed (kennel). I would hesitate to use it on a cat if they like the taste this much. It might end up making the issue worse by encouraging them to lick the area more.

Rated 5 out of 5 stars
By Sherilyn on Sep 3, 2025

Topical skin cream for cats

This cream really helps with his dry skin on his ears and his belly. I put a thin layer on twice a day and he’s not scratching or chewing at the spots any more

This cream really helps with his dry skin on his ears and his belly. I put a thin layer on twice a day and he’s not scratching or chewing at the spots any more. Highly recommend this product to anyone who needs help relieving their cats itchy skin.

Rated 1 out of 5 stars
By Denise on Aug 25, 2025

DO NOT USE

I purposely bought this item because it explained that it was safe. my cat got incredibly sick. bleeding from her bottom and has lost a lot of weight and is still

I purposely bought this item because it explained that it was safe. my cat got incredibly sick. bleeding from her bottom and has lost a lot of weight and is still healing. Shame on you for your lying advertising.

Rated 5 out of 5 stars
By Tim on Aug 13, 2025

Cream medication.

My cat had terrible rashes on her belly and constantly picked them. Since applying the cream, I notice a big difference. Seems to be healing well

My cat had terrible rashes on her belly and constantly picked them. Since applying the cream, I notice a big difference. Seems to be healing well

Rated 5 out of 5 stars
By Mary on Dec 20, 2025

Worked great

IT only takes a little bit to work

IT only takes a little bit to work

Rated 5 out of 5 stars
By Caren on Nov 9, 2025

The price

Amazing took hot spot away in 3 days

Amazing took hot spot away in 3 days

Rated 5 out of 5 stars
By Christine on Aug 14, 2025

Itchys all gone

It gave Bonnie instant relief and he is getting much better.

It gave Bonnie instant relief and he is getting much better.

Rated 5 out of 5 stars
By Elizabeth on Mar 24, 2025

Helped my cat!

Spoke with a vet who told me to give this a try and it works! Our cat had a few mystery marks after getting out of the house and after putting it on him for a week

Spoke with a vet who told me to give this a try and it works! Our cat had a few mystery marks after getting out of the house and after putting it on him for a week there have been great improvements!