Zymox Topical Dog & Cat Enzymatic Skin Cream, 1-oz tube

By Zymox
Rated 4.3918 out of 5 stars
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$11.79Chewy Price
$15.99Chewy Price
$11.20Autoship Price
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About This Item

  • For hot spots, body fold irritations, wounds, cuts, and skin infections due to bacteria, fungus or yeast plus ringworm, staph and MRSA.
  • Potent combination of milk-derived enzymes help the pet's immune system handle harmful microbes and fight infection.
  • Antibiotic alternative contains no hydrocortisone, which can cause side effects in some pets.
  • Non-toxic formula is safe for dogs, even if licked, and requires no pre-cleaning before the easy, once-a-day application.
  • Made in the USA.
Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsAloe Vera, Benzyl Alcohol, Dextrose...Shea Butter, Coconut Oil, Colloidal Oatmeal...Purified Water,  Stearyl Alcohol, Cetyl Alcohol...Purified Water, Nano-Enhanced Minerals, Witch Hazel Extract...
Health FeatureSkin & Coat HealthCalmingSkin & Coat Health, Itch & Redness RemedySkin & Coat HealthSkin & Coat Health
Breed SizeSmall Breeds, Medium Breeds, Large Breeds

Questions & Answers

19 Customer Questions

My dog has folliculitis on her chin. Is this safe to use this close to her mouth? She could obviously not lick it but still want to make sure we buy something safe..
Answer by ChewyFeb 07, 2018
Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use. This product is for external use only. It's safe for use around the mouth but avoid contact with eyes. Stop use and consult veterinarian if condition gets worse or a rash or other allergic reaction develops.

Can this be used in or on cats ears?
Answer by ChewyJul 01, 2021
It is recommended to avoid contact with eyes or mucous membranes. Do not apply to large areas of the body. We recommend speaking to your vet to see if this would be suitable for your pet's current treatment plan.

What is the difference between the ointment and the topical spray?
Answer by ChewyDec 21, 2019
Both the medicated ointment and topical spray share the same ingredients, but different packaging forms offer pet parents a way to choose their pet's most convenient application.

My cat is severely allergic to fleas and has lost most fur on her rear area due to over grooming from the itching. Would this help her?
Answer by ChewyApr 06, 2018
We encourage speaking with your Veterinarian before combining supplements, for the safest opinion.

ReviewsWrite a Review

Rated 4.3918 out of 5 stars
97 Reviews
Would recommend to a friend

97 Customer Reviews

Rated 5 out of 5 stars
By Nancy on Jun 13, 2022

Skin problem

I purchased this product for what I felt was a very unuasual skin problem and it cleared it up very nicely. Because it delt with other kinds of germs besides bacterial, I feel that it did what I needed it to do. Skin is healthy and in fine shape.

Rated 5 out of 5 stars
By cgrantg on Apr 14, 2022

The 5 stars are for the 1% cream (this is 0.5%)

There is a version of the Zymox topical cream with 1% hydrocortisone available from Chewy. I believe that the product pictured here is for the 0.5% cream. I would buy the 1%, because it provides more itch relief. My Maine Coon has "allergy ears" at various times during the year, and he scratches so hard he causes bleeding (I try to keep his back nails trimmed because of this). This topical cream, applied once a day for 2 or 3 days to the base and tips of ears, eases itching and dries out the wounded areas.

Rated 5 out of 5 stars
By EtoileM on Apr 12, 2022

Does help with her chin acne

My cat has terrible chin acne and pulls out hair from her belly and lower legs. This cream does help. I do have to take her for allergy shots too.

Rated 5 out of 5 stars
By Gravy on Feb 5, 2022

Wonderful cream did its job

Kudos to both the product and the consult Vet service from Chewy! I explained my cats problem with a rash on his ears not associated with mites and the vet recommended this and it cleared it right up! Nice to have around the house as I am a rescuer and currently I have four cats and three dogs! It can be used on either!

Rated 5 out of 5 stars
By Rosie on Nov 28, 2021

Bought this to try out on my cats' ringworm

I bought this to try out on my cats' ringworm, they have been battling with it for a while and after many very expensive vet's visits and medicine to try and get rid of it, and it just keeps coming back, I wanted to try an alternative and less expensive method and see if I get better results. I bought this a few weeks ago and so far seems to be working but I know I have to use if for a while longer to determine if it actually gets rid of the ringworm. I do want to say I am glad to have this website to go to for easier access to different types of products even medicine for pets. It is definitely an ease of mind I can go there without having to go to a costly vet every week.

Rated 1 out of 5 stars
By Melly on Apr 26, 2022

It did not help

It did not help Orangee's skin issue. : ( Maybe for others it does I am not sure.

Rated 5 out of 5 stars
By kitt on Dec 10, 2021

it works!!!

My cat had a small bald spot on the back of her neck for a few months. It wasn’t growing back hair and looked irritated from scratching. This cream helped the irritation and now her fur is growing back. I applied the cream onto the spot every 12 hours for about 10 days. This cream also states that it is safe if they accidentally lick it, that was something I wanted to make sure of. I am very impressed 10:10

Rated 5 out of 5 stars
By Karla on Jan 8, 2022

This is a lifesaver

My Frenchie has skin allergies and gets the occasional hotspot or skin dryness, this cream is effective and fast. I have purchased other skin creams for dogs but this is the only one that works for my dog.

Rated 5 out of 5 stars
By Steve on Apr 17, 2022

Ointment for pet.

Great product my cat did not like my put it on her but it help a lot

Rated 5 out of 5 stars
By Fungal on Sep 22, 2021

Highly recommend!

My pug puppy started loosing her fur around her wrinkles around mid May and we tried almost everything to help her to grow that fur back and nothing worked. I decided to look through Chewys website and found this amazing product, after less than a month using it, there is a tremendous difference and her fur finally grew back in! I recommended this product for those pups that are dealing with similar situations as mine. On the picture you will see her before and after using this cream