Zymox Plus Advanced Formula Otic Dog & Cat Ear Infection Solution, 1.25-fl oz bottle

$19.49 First Time Autoship Price
this order
Save 35% (up to $20) today when you set up Autoship. 

$29.99 Autoship Price
future orders
  • Get deliveries on your schedule
  • Skip, change, or cancel anytime
$29.99 Chewy Price
($24.00 /fl oz)
Save $10.00 (-25%)
$39.99 List Price
Promo, Spend $100, Get $30 eGift Card with code NEWYEAR
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME

In Stock
FREE 1-3 day delivery on first-time orders over $35
Free 365-day returns

No interest if paid in full in 6 months on PayPal purchases of $149+. .

About This Item

Details

  • Naturally occurring enzymes are highly effective against bacterial, fungal and yeast ear infections. Great alternative to antibiotics and the non-toxic solution won’t irritate a pet’s sensitive or irritated skin. Safe enough for nursing/lactating pets and sensitive exotics.
  • Proven antimicrobial LP3 Enzyme System inhibits, splits and destroys the offending organisms while leaving healthy cells alone.
  • Four additional biofilm-reducing enzymes destroy the hard-to-penetrate biofilm slime layer that obscures the microbe.
  • Ideal for cases of repeated infections or infections that won’t resolve, and bacteria will never develop a resistance to the enzymes.
  • Made in the USA.

Ingredients

Instructions

Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.

About ZYMOX

Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.
Shop ZYMOX

Questions & Answers

12 Customer Questions


Will this help get rid of possible mites in ears?

Answer by ChewyMay 01, 2024
This solution contains a patented combination of enzymes to provide relief of persistent or recurring ear irritations and promote healthy ears and is not formulated for use against ear mites.

Does this contain hydrocortisone?

Answer by ChewyAug 31, 2017
This solution does not contain Hydrocortisone.

What os the "active" ingredient in this product?

Answer by ChewyMar 04, 2020
This solution contains an antimicrobial LP3 Enzyme System with four biofilm-reducing enzymes

Does zymox contain Xylitol advanced formula zymox plus in the gold packaging????

Answer by ChewyOct 23, 2019
This Zymox Plus solution does not contain any Xylitol.

4.6
Rated 4.6 out of 5 stars
241 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

95% Positive

Ease of Use

96% Positive

Effectiveness

96% Positive

Safety

94% Positive

119 Customer Reviews



Rated 5 out of 5 stars
By Adriana on Dec 16, 2025

Works like a charm

My 80 pound boxer gets stinky disgusting smelling ears. Whenever I use this product for seven days, it all goes away. Highly recommend this product the red one

My 80 pound boxer gets stinky disgusting smelling ears. Whenever I use this product for seven days, it all goes away. Highly recommend this product the red one as well.


Rated 5 out of 5 stars
By Shirley on Nov 4, 2025

It works!

My poor pup has many allergies and scratches her ears regularly. Zymox keeps the ear infections under control for her -the vet likes this product also

My poor pup has many allergies and scratches her ears regularly. Zymox keeps the ear infections under control for her -the vet likes this product also


Rated 5 out of 5 stars
By Kim on Aug 13, 2025

Works quickly and effectively to clear up brown ear guck.

I have used this product as needed for about 6 years. It is a go to for the first signs of ear discharge. Works like a charm quickly and effectively. It is not irritating

I have used this product as needed for about 6 years. It is a go to for the first signs of ear discharge. Works like a charm quickly and effectively. It is not irritating and my dog tolerates it well... which is a BIG plus for a very sensitive pooch.


Rated 5 out of 5 stars
By Debra on Sep 7, 2025

Love it!

I received Mooses collar yesterday. It was easy to adjust to fit it to his neck. The white background really makes out makes the design pop so everyone knows what

I received Mooses collar yesterday. It was easy to adjust to fit it to his neck. The white background really makes out makes the design pop so everyone knows what team we root for.


Rated 5 out of 5 stars
By Mollie on Aug 20, 2025

It works

Lady get inner ear infections and this medicine helped clear it up when using for the 7 days as directed.

Lady get inner ear infections and this medicine helped clear it up when using for the 7 days as directed.


Rated 5 out of 5 stars
By Jennifer on Jul 8, 2025

Works like a charm

Saw results immediately. Our frenchie had cauliflower ear on the right side, was constantly itching and this helped clear it up within a week.

Saw results immediately. Our frenchie had cauliflower ear on the right side, was constantly itching and this helped clear it up within a week.


Rated 5 out of 5 stars
By Megan on Jun 5, 2025

It helped

My pup experienced a severe ear infection. The Zymox was helpful in reducing the infection. I wish I had used it sooner; perhaps the infection could have been

My pup experienced a severe ear infection. The Zymox was helpful in reducing the infection. I wish I had used it sooner; perhaps the infection could have been prevented.


Rated 4 out of 5 stars
By Laurel on Aug 1, 2025

Works great

My German shepherd suffers from chronic ear infections and this works great for him

My German shepherd suffers from chronic ear infections and this works great for him


Rated 5 out of 5 stars
By Jill on May 14, 2025

Advanced formula

This helped our lab who has continuous double ear infections. He is no longer shaking his head and whinning.

This helped our lab who has continuous double ear infections. He is no longer shaking his head and whinning.


Rated 5 out of 5 stars
By Anne on Jun 15, 2025

Allergies and ear scratching

This stuff is magic . Drains the mess out of her ear . Makes her comfortable .

This stuff is magic . Drains the mess out of her ear . Makes her comfortable .