21st Century Essential Pet Pet-EZE Calming Soft Chews Supplement for Dogs, 120 count

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Help keep your canine companion calm and centered with 21st Century Essential Pet’s Pet-EZE. These tasty soft chews are an excellent treat to give your comrade in times of stress like while traveling, during grooming or on a trip to the vet. This calming blend contains natural herbs like chamomile and amino acids like L-Tryptophan. The body changes L-tryptophan into serotonin which can help control mood and sleep. It’s also made in the USA and has been tested in a laboratory, so you can feel confident knowing that your dog is getting the high-quality treatment he deserves.

Key Benefits
  • Contains soothing chamomile which is often used to help reduce stress and promote sleep.
  • L-Tryptophan is an amino acid that changes into serotonin once in the body, which can help control mood and sleep.
  • Formulated to help your dog during stressful situations like road trips, trips to the vet, grooming, during fireworks and more.
  • The soft and chewy texture serves as a great alternative for dogs who have a difficult time taking pills.
  • Proudly made in the USA and tested in a laboratory to ensure quality.

For animal use only. Keep out of reach of children and animals. In case of accidental overdose, contact a health professional immediately. Do not use if product appears to be tampered with or seal is broken.

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See all items by 21st Century Essential Pet

  • Item Number
  • NASC Certified
  • Lifestage
    Adult, Puppy, Senior
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds, All Breeds, Giant Breeds, Extra Small & Toy Breeds
  • Food Form
  • Product Form
    Soft Chew
Nutritional Info

Active Ingredients: Chamomile Flower (Matricaria Recutita), Ginger Root Extract (Zingiber Officinale), Thiamine (Vitamin B1), L-Taurine, L-Tryptophan.

Inactive Ingredients: Brewer's Dried Yeast, Calcium Propionate, Canola Oil, Caramel Color, Corn Starch, Dried Cheese, Green Tea Extract, Liver Meal, Mixed Tocopherols, Natural Flavors, Rice Bran, Rosemary Extract, Sorbic Acid, Soy Lecithin, Vegetable Glycerin, Vegetable Oil, Water, Yucca Extract.

Active Ingredients (Per One Chewable
Chamomile Flower (Matricaria Recutita 100 mg
Ginger Root Extract (Zingiber Officinale)50 mg
Thiamine (Vitamin B1)25 mg
L-Taurine20 mg
L-Tryptophan15 mg
Feeding Instructions
WeightDaily Feeding
10-20 lbs2 soft chews
Over 20 lbs1 soft chew for every 10 lbs

Daily feeding should not exceed 4 soft chews. Do not exceed 7 consecutive days at a time. For use in adult dogs.

If animal's condition worsens or does not improve, discontinue use and consult your veterinarian. Do not use this product prior to anesthesia or prior to surgery. An examination from a veterinarian is recommended prior to using this product. Make sure your dog has plenty of water when using this product.

This product is intended for intermittent or supplemental feeding only.

An examination by a veterinarian is recommended prior to using this product.

Store product in cool, dry place. Avoid temperatures above 86 degrees F.


Why should I include vitamins & supplements in my pet’s diet?

Most commercial pet foods include baseline vitamins and nutrients, but some may not have the adequate amount to suit your pet’s exact health needs. Like in humans, vitamins and supplements can help support your pet’s long-term health, regulating everything from digestion to muscle growth. Consult your veterinarian to determine the best vitamins and supplements for your furry friend.

How often should I give this supplement to my pet?

It is recommended to give the suggested dosage based off your pet’s weight. Please refer to the Feeding Instructions tab and consult with your veterinarian for more information.

Is this supplement safe to use with the medication my pet is currently taking?

If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use.

My pet is allergic to certain ingredients, will this product be safe to use?

For a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos. If you are unsure about the safety of this product for your pet, we recommend consulting with your veterinarian.

Does this product come in other product forms?

For a complete assortment of products by the manufacturer of this supplement, click on the link next to the item name at the top of the page. You can also find an assortment of supplements across all product forms on our page.

Rating: 3.1 of 5 stars 19 Reviews 19 Reviews 3.1 out of 5 Stars

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68% Recommend

68% of reviewersrecommend this product

Rating: 3.1 of 5 stars 3.1 / 5

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19 Reviews

Showing 1-10 of 19 Reviews

  • 1 out of 5 stars

    Awful Smell

    By barbie115 on Nov 23, 2021

    These chews have a horrendous smell that eventually emanates from your dog. Although my dog is calmer the smell is hideous.

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  • 1 out of 5 stars

    Adverse response

    By Jenn on Feb 9, 2021

    We notice that when we give these to our dog, his behavior changes immediately-not in a good way. He is incredibly hyper when people come over, so we thought this may be a good way to quell that. He will not leave our side, to the point of sitting on our feet because he can't get close enough to us. He also gets trembly the next day. I'm guessing it is the result of all of the energy that he usually exerts being hindered, thus giving him the shakes. Max dose for his weight says 6; we give him 2. We've tried it on 3 occasions, and will no longer use this product. If I could rate 0 stars, I would.

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  • 1 out of 5 stars

    Disgusting Cat Pee Smell

    By ekkk on Apr 20, 2021

    Absolutely the worst smelling things I have ever opened. Will not suggest these to anyone. I smothered one with peanut butter and my dog still wouldn’t touch!

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  • 5 out of 5 stars

    Works pretty good

    By Colliemom on Aug 6, 2020

    My dog is blind and therefore thunder terrorizes him. I've tried everything including thundershirt, wiping a dryer sheet on his fur, benedryl, CBD, Bach Flower Essence's , Rescue Remedy, etc. This will knock him out. He is 60 pounds and I give 2 or 3 depending on the level of rain and thunder coming. A major crack of thunder (we live near mountain so its so close) will wake him up and then its back to panting, pacing and freaking out. I will give 3 if its predicted bad. But my goto is to sit with him in an inside closet or bathroom and play dog meditation ytubes. Dog does not mind the smell or taste at all. Giving 5 stars because I think its the best I've tried.

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  • 1 out of 5 stars

    Calming soft chews

    By Dusty on Sep 8, 2020

    For Dusty a change in what works best wasn't good. I thought trying this brand sounded good. But he is hyper, nerves and bark's at everything. So I can't give them 4stars just one. We're going back to his usual brand

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  • 3 out of 5 stars

    Terrible Smell, but they seem to help!

    By Jack on Jul 5, 2020

    While I believe these help my pups with anxiety (we got them to aid our dogs in storm anxiety and fireworks this summer), the smell is so bad it took my breath away when I opened them. I assumed they were bad but a friend that uses them said they just always smell awful. Our dogs wouldn’t eat them unless we coated in peanut butter. They definitely calm the dogs, but they’re really rancid smelling. They might warn users of the smell / if you open them the smell escapes and lingers in that space. Really really bad!

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  • 1 out of 5 stars

    refuses to eat

    By doxiemom on Aug 18, 2020

    My dachshund HATES the taste of these treats. I tricked him in to eating them a few times by crumbling into his food. Also, he never eats his poop, but did after eating these. Oh yeah, they don't work anyway! Waste of money.

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  • 5 out of 5 stars

    great product

    By joanne on Jun 20, 2020

    My catahoula mix is afraid for thunderstorms and fireworks. Pet-eze really works. A couple of these and he is not bothered as much. I see a difference in him. I use a thunder shirt as a backup. Sometimes pet-EZE is used alone and works great.

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  • 5 out of 5 stars

    These work!

    By Creepers on May 28, 2020

    I have 3 Border Collies and all three have different levels of storm anxiety and these work great . Takes the edge off and everyone sleeps through the storms. My dogs love them and consider them a yummy treat.

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  • 1 out of 5 stars

    My dog won't eat these.

    By Trish on Jun 27, 2020

    These may be good as well as calming for some dogs, but mine won't eat them. They smell awful so I can't blame her.

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