Acepromazine Maleate (Generic) Tablets for Dogs, slide 1 of 1

Acepromazine Maleate (Generic) Tablets for Dogs

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Strength: 25-mg
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Count: 1 tablet
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Acepromazine Maleate is a prescription medication for dogs who need tranquilization or for dogs who suffer from motion sickness. It’s used as a pre-anesthetic and as an anti-emetic to prevent vomiting due to motion sickness. This medication is not a pain reliever but can be used to sedate animals for minor procedures, such as nail trims. It comes in an uncoated tablet form, so you can easily hide it in a pill pocket and give it as a tasty treat or disguise it in your dog’s favorite wet food. Customers may receive this drug under the names PromAce, Aceproject.

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Acepromazine Tablets can be used as an aid in controlling intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures.

Possible Side Effects

A few rare but serious occurrences of idiosyncratic reactions to acepromazine may occur in dogs following oral or parenteral administration. These potentially serious adverse reactions include behavioral disorders in dogs such as aggression, biting/chewing, and nervousness.

Drug & Food Interactions

Antacids and antidiarrheal medications may reduce the effectiveness of this medication. Before starting acepromazine, tell your veterinarian if your pet is currently taking phenytoin, antiarrhythmics like quinidine, or beta blockers such as propranolol. Other drug interactions may occur.


Tranquilizers are potent central nervous system depressants, and they can cause marked sedation with suppression of the sympathetic nervous system. Tranquilizers can produce prolonged depression or motor restlessness when given in excessive amounts or when given to sensitive animals. Tranquilizers are additive in action to the actions of other depressants and will potentiate general anesthesia. Tranquilizers should be administered in smaller doses and with greater care during general anesthesia and also to animals exhibiting symptoms of stress, debilitation, cardiac disease, sympathetic blockade, hypovolemia or shock. Acepromazine, like other phenothiazine derivatives, is detoxified in the liver; therefore, it should be used with caution on animals with a previous history of liver dysfunction or leukopenia.

NOTE: For Generic Medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer. Please note product may arrive in a Chewy Pharmacy vial.

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  1. Prescribing Information

See all items by Acepromazine

  • Item Number
  • Common Brand Name(s)
    PromAce, Aceproject
  • For Use With
  • Generic Name
    Acepromazine Maleate
  • Administration Form
  • Product Form
  • Health Condition
    Anxiety, Motion Sickness
  • Drug Type


Recommended Dosage

Dose varies based on pet's weight. Use according to your veterinarian's instructions.

Storage Instructions

Store at temperatures from 68° - 77°F.


What is Acepromazine?

Acepromazine is a prescription tranquilizer. Acepromazine is used to sedate animals for minor procedures (e.g., nail trims) and has also been used to prevent vomiting due to motion sickness. It is also used prior to anesthesia as a pre-anesthetic.

What are the benefits of Acepromazine?

Prescription tranquilizer sedates animals for minor procedures including nail trims. May be used prior to anesthesia.

How is this medication given?

Acepromazine tablets are given by mouth. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian. This medication should only be given to the pet for whom it was prescribed.

How does this medication work?

Acepromazine is a tranquilizer that depresses certain activity of the central nervous system and causes sedation and muscle relaxation.

What results can I expect?

Oral acepromazine will not reach its maximum effective level until approximately one hour after administration. The effect may last up to 12 hours. The effects vary markedly among dog breeds. Collies, Australian shepherds, greyhounds and giant breeds may be more sensitive to this medication.

Rating: 4.4 of 5 stars 19 Reviews 19 Reviews 4.5 out of 5 Stars

95% Recommend

95% of reviewersrecommend this product

Rating: 4.4 of 5 stars 4.5 / 5

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19 Reviews

Showing 1-10 of 19 Reviews

  • 5 out of 5 stars

    Acepromazine results

    By Keeghan on Jun 17, 2021

    My pup has severe anxiety with thunderstorms and fireworks. Fireworks are a regular part of life in my area in the summertime. I have tried several different medications but most either did nothing or made him groggy for the day. With this medication though I give it to him at the first signs of his anxiety and within 30 minutes he settles right down. What a lifesaver for both of us. He is still able to do all the things he likes to do while on the medication but minus the anxiety. I do not use this every day but only when needed, especially in the summer.

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  • 5 out of 5 stars

    Awesome pricing

    By SusanH on Sep 6, 2021

    My vet charged as much for SIX pills as you do for 30!! And that includes shipping! I'm so glad we found you! Thank you!

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  • 4 out of 5 stars

    Almost perfect

    By Kiki on Aug 17, 2021

    I needed half the dosage - but the pills are easy to break in half.

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  • 5 out of 5 stars

    Drugs to calm my dogs

    By Laurie on Mar 17, 2021

    I have two hyperactive dogs (biological brother and sister) who are constantly in motion and bark all the time. Acepromazine has taken the edge off of them and they are so much nicer to be around. It has also helped with their fear of thunder and gunshot noise. I would recommend this drug for any dog who is excitable.

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  • 5 out of 5 stars

    The Best!!!

    By Rhonda on May 10, 2021

    It’s really hard for me to get to my dog’s vet to get her medication. So the fact that chewy has it is great!

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  • 5 out of 5 stars

    Just what the doctor ordered.

    By Aldo on Jan 2, 2021

    Medication was as prescribed and does exactly what is is supposed to do.

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  • 1 out of 5 stars

    Should’ve been cut by the pharmacist

    By Teddy on Aug 4, 2020

    I wouldn’t use it unless you really have to I use it for my dog for thunderstorms but the side effects are not good the next day he’s very groggy which is OK but he gets aggressive. These pills need to be cut up before they are delivered they didn’t cut them up for me and when you try to cut them yourself they break in pieces I have another medicine that I like it much better because they don’t hear the thunder as much he panics we had bad storms last night and hurricane warning so I had to give him the pill is used for emergencies only

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  • 5 out of 5 stars

    Acepromazine - my scardy pills

    By Sadiekins on Jun 13, 2020

    My humans ordered these pills for me because whenever there are fireworks, or thunder i am very scared. The pharmacy that they ordered them from gave my mum free shipping and the pills arrived really quickly. I love it when my humans give me these pills because i am able to sleep peacefully without shaking and without having to sit on my mums lap, even though i am a Labrador dog and weight 85 lbs. I recommend you get some of these pills!

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  • 5 out of 5 stars


    By Stone on Jul 7, 2020

    Chewy is the greatest. I m do glad that I get most products from you. You as are always on time even with the covid 19. I could not ask for a better company. thank you. Thank you

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  • 5 out of 5 stars

    Thank you for all your help

    By anne on Jul 17, 2020

    Thank you for all your patience and perseverance in getting this script from the vet's office. I thank you very much!

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