Clomipramine Hydrochloride (Generic) Tablets

Prescription Item

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Strength: 20 mg
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Count: 1 tablet

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Some furry friends have a very hard time being separated from their pet parents, but thankfully there are ways to help. Clomipramine Hydrochloride (Generic) Tablets is a prescriptions medication formulated to help reduce clinical signs of separation anxiety. It works by affecting serotonergic and noradrenergic neuronal transmission into your pet’s central nervous system. And for easy oral administration, this medication comes in a convenient tablet form.


Separation anxiety in dogs six months and older.

Possible Side Effects

Possible side effects are emesis, letargy, and anorexia

Drug & Food Interactions

Data generated in humans. Plasma levels of tricyclic antidepressants have been reported to be decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin); therefore plasma concentrations of clomipramine may be decreased by the concomitant administration of phenobarbital. Plasma levels of closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine). Caution is advised in using clomipramine with anticholinergic or sympathomimetic drugs or with other CNS-active drugs, including general anesthetics and neuroleptics. Prior to elective surgery with general anesthetics, clomipramine should be discontinued for as long as clinically feasilble.


Clomipramine Hydrochloride Tablets are not recommended for other behavior problems, such as aggression. Studies to establish safety and efficacy of Clomipramine Hydrochloride Tablets in dogs less than 6 months of age have not been conducted.

  1. Prescribing Information

See all items by Clomipramine Hydrochloride

  • Item Number
  • For Use With
  • Common Brand Name(s)
    Clomicalm, Anafranil
  • Generic Name
    Clomipramine Hydrochloride
  • Administration Form
  • Lifestage
  • Product Form
  • Health Condition
  • Drug Type

Active ingredients: Clomipramine Hydrochloride. Inactive Ingredients: Colloidal Silicon Dioxide, Crospovidone Polyplasdone, Dry Beef Flavor, Lactose Monohydrate, Magnesium Stearate, Microcrystalline Cellulose, Providone K-30.

Recommended Dosage

The recommended dose is 2 to 4 mg/kg/day (0.9 to 1.8 mg/lb/day.) It may be administered as a single daily dose or divided twice daily based on patient response and/or tolerance to side effects.

Storage Instructions

Store in dry place at controlled room temperature, between 59 and 77°F (12-25°C). Store unused tablets in the original closed container.


Is this item scored?

  • Yes, Clomipramine Hydrochloride Tablets are scored for easy splitting.

Is there any flavoring on this item?

  • Clomipramine Hydrochloride Tablets has a natural beef flavoring, your pet will love it!

How old does my dog have to be to use this item?

  • Clomipramine Hydrochloride Tablets are for use in dogs 6 months and older.
Rating: 3.0 of 5 stars 1 Review 1 Review 3 out of 5 Stars

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  • 3 out of 5 stars

    Works OK but isn't a cure all.

    By HisPill on Jan 14, 2021

    This medication seems to put him to sleep. I'm not sure his behavior is much different, even with behavior modification training.

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