Credelio Chewable Tablets for Cats, 2-4 lbs, (Purple Box), 1 Chewable Tablet (1-mo. supply)

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Credelio Chewable Tablets for Cats, 2-4 lbs. comes in a small, flavored chewable tablet form and is prescribed to provide monthly protection against ticks and fleas for cats and kittens. Credelio is rapidly absorbed, and after 24 hours kills at least 99% of ticks and 100% of fleas for a whole month. This medication is easy to administer and can either be placed directly in your cat companion’s mouth or easily disguised in her favorite food!

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CREDELIO CAT kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) for one month in cats and kittens 8 weeks of age and older, and weighing 2.0 pounds or greater. CREDELIO CAT is also indicated for the treatment and control of Ixodes scapularis (black-legged tick) infestations for one month in cats and kittens 6 months of age and older, and weighing 2.0 pounds or greater.

Possible Side Effects

In a well-controlled U.S. field study, which included 341 cats (228 cats treated with CREDELIO CAT and 113 cats treated with a topical active control), there were no serious adverse reactions.

Drug & Food Interactions

There are no known contraindications for the use of CREDELIO CAT.


Lotilaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, incoordination, and seizures. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Use with caution in cats with a history of neurologic disorders. The safety of Credelio CAT has not been established in breeding, pregnant and lactating cats. The most frequently reported adverse reactions are weight loss, rapid breathing and vomiting. For complete safety information, please see Credelio CAT product label or ask your veterinarian.

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  1. Package Insert

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  • Item Number
  • Administration Form
  • For Use With
  • Generic Name
  • Common Brand Name(s)
  • Lifestage
  • Breed Size
    Extra Small & Toy Breeds, Small Breeds
  • Product Form
    Chewable Tablet
  • Strength
    12 mg Lotilaner
  • Health Condition
    Fleas, Ticks
  • Drug Type


Recommended Dosage

Use only as directed by your veterinarian

Storage Instructions

Store between 59 - 77 F


Why would an indoor cat need flea and tick protection?

One of the most common misconceptions about indoor cats is that they are not at risk for fleas and ticks. Fleas and ticks can be brought into the home on people’s shoes and clothing, and readily infest cats from there. Other pets in the home can also put indoor cats at risk. For example, if a pet owner also has a dog that regularly goes outside, that cat is also at risk for fleas and ticks. Additionally, indoor cats may not be as “indoor” as they seem with short trips to the yard, patio or porch where they can be exposed to fleas and ticks as well.

What are some common signs of fleas on cats?

Common clinical signs include increased, over-active grooming, itchiness, patches of hair loss with reddened skin, small bumpy scabs along the flanks or back end and large scabs around the face. These signs can mimic a number of other issues in cats, including allergies, so it is always a good idea to proactively treat for fleas. Ironically, cats with flea infestations often have an apparent absence of fleas. This is because they are commonly removed by cats through their daily grooming and is a major reason why cat owners and even veterinarians have difficulty realizing a cat has fleas. If fleas are found, they are most often found around the head and neck area.

How fast does Credelio CAT (lotilaner) start killing fleas?

In a well-controlled laboratory study, Credelio Cat began to kill fleas six hours after administration, with >98% of fleas killed within 12 hours after administration. In another well-controlled laboratory study, Credelio Cat demonstrated 100% effectiveness against adult fleas 24 hours after administration or infestation for 35 days. Credelio maintains high, fast-acting and sustained flea efficacy throughout the month.

Which ticks are Credelio Cat labeled for?

Credelio Cat is labeled for the black-legged tick, also known as Ixodes scapularis. This is the most common tick infesting cats in the United States1 and is a threat to cats spring through fall. They transmit Lyme disease and anaplasmosis to cats. True prevalence of these diseases in cats is difficult to determine.

What is the best way to administer Credelio Cat?

All owners have different comfort levels with their cat when it comes to administering medication. There are three basic ways to administer Credelio Cat: 1. Offer by hand or place in area where your cat feels comfortable eating. Many cats will eat the chewable by free choice. Tempting with treats can also help. 2. Offer with food during a meal. If your cat is a grazer, try placing it around a few pieces of kibble or covered in wet food and checking to make sure it has been consumed out of the bowl. 3. Place the chewable on the back of your cat’s tongue. The chewables were designed to be very small and easy to administer in these situations. It is important to always administer Credelio Cat with a meal or 30 minutes after feeding.

Why is food so important when administering Credelio Cat?

Food enhances the absorption and bioavailability of lotilaner in cats. In fact, when given with food, 100% of lotilaner reached systemic circulation as opposed to only 8% in unfed cats. Credelio Cat needs to be administered with food or within 30 minutes of feeding. This will ensure high blood concentrations and sustained efficacy throughout the month.

Is Credelio CAT (lotilaner) safe?

Credelio Cat is FDA-approved as safe and effective when used according to the label.

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  • 5 out of 5 stars

    Flea Meds for small cats

    By Tess on Oct 8, 2021

    Easy for kitty to chew and swallow. Turn around time for ordering and receiving product is fast.

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