Credelio Quattro Chewable Tablets for Dogs, 50.1-100 lbs, 6 Chewables (6-mos. supply)

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About This Item

Details

  • Credelio Quattro: The broadest1 parasite protection of its kind covering 6 types of parasites, including ticks, in one chewable tablet.
1

Based on label comparison of the number of parasite types covered in an isoxazoline endectocide. - This monthly flea and tick treatment also protects against heartworm disease and three intestinal worms that can be passed to humans – roundworms, hookworms† and tapeworms † Uncinaria stenocephala - Easy-to-Give Chewable: This FDA-approved parasite protection comes in a flavored chewable tablet that is given once a month with food or within 30 minutes of a meal. - Prescription Only: Credelio Quattro is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.

Ingredients

Instructions

FAQ

Get 6-in-1 Parasite Protection

Introducing Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) for dogs, a prescription medication that protects your dog from common parasites. Unlike other chewables, Credellio Quattro protects against 6 types of parasites, including ticks, fleas, heartworm disease and three intestinal worms that can be passed to humans – 3 species of tapeworms, roundworms and hookworms.

Protection in a Tasty Chewable

Credelio Quattro combines convenience with flavor. A beef-flavored, once-monthly tablet that makes it easy to administer. Enjoy peace of mind knowing your dog’s protection is effective and easy to give.

The Power of Four

Credelio Quattro features four tried and true active ingredients designed to combat parasites effectively. With lotilaner, moxidectin, pyrantel and praziquantel, this advanced formula provides your pet with the broadest parasite protection of its kind based on label comparison of the number of parasite types covered.

Shown To Be Safe for Dogs and Puppies

Use Credelio Quattro to help protect your dog proactively before problems happen. This preventive treatment is shown to be safe for puppies as young as 8 weeks old and weighing at least 3.3 lbs.

About Credelio Quattro

Prescription only. Ask your veterinarian if Credelio Quattro is right for your dog.

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Indications

Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm, and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.

Important Safety Information

Lotilaner, an ingredient in Credelio Quattro, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, ataxia, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro administration as it is not effective against adult D. immitis. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. For complete safety information, please see the Credelio Quattro product label or ask your veterinarian.

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Reviews
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4.6
Rated 4.6 out of 5 stars
328 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

86% Positive

Effectiveness

84% Positive

Ingredients

84% Positive

Long-Term Benefits

84% Positive

111 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 1 out of 5 stars
By Patricia on Jan 3, 2026

poor delivery

Dogs do well on the prescription. However: Rcvd notification package was delivered. Camera did not show arrival. Checked at door in case camera malfunctioned

Dogs do well on the prescription. However: Rcvd notification package was delivered. Camera did not show arrival. Checked at door in case camera malfunctioned. Nope, no package. When checking website re: delivery; stated that pkg was left at front door. Walking dogs next morning, found package had been left on top of mailbox. Over $400.00 in dog meds left on the top of the mailbox on a dirt road at a rural address with properties more than an acre apart. Called Chewy to state dissatisfaction. C/S apologized. I'll find another supplier.

Rated 4 out of 5 stars
By Oliver on Jan 16, 2026

huge pill & very pricy - but it works!

this medication does a great job (we have not seen ANY fleas or ticks on our dog since starting it) BUT the pills are absolutely huge, like comically large. this

this medication does a great job (we have not seen ANY fleas or ticks on our dog since starting it) BUT the pills are absolutely huge, like comically large. this will be a real challenge if your dog has a hard time with pills. Chewy has by far the best price for this item especially with the chewy plus and autoship, but it is still very pricy, would be great to see this on sale more often, or see the price lowered.

Rated 1 out of 5 stars
By Kathy on Dec 6, 2025

My dogs hate these pills

I have 3 dogs. 2 of them will eat virtually anything. Except Credelio Quattro. It's laughable that they are chews b/c my dogs will spit them out 100% of the time

I have 3 dogs. 2 of them will eat virtually anything. Except Credelio Quattro. It's laughable that they are chews b/c my dogs will spit them out 100% of the time even when hidden in cheese, peanut butter, pills pockets. There is no disguising the horrible taste and massive size of these things. They do work well but for the price and the major hassle of trying to get the dogs to take them, I'm not sure it's worth it.

Rated 2 out of 5 stars
By Marina on Dec 4, 2025

Do not pay with Apple Pay saved credit cards

The product is an excellent product and I’ve been very pleased with the results. However I paid using a credit card in Apple Pay and got billed twice. Chewy claimed

The product is an excellent product and I’ve been very pleased with the results. However I paid using a credit card in Apple Pay and got billed twice. Chewy claimed the first was a “soft” pay and was reversed in their system however my credit card was billed twice with no credit for the first payment. My advice is do not pay with a credit card stored in Apple Pay, use a card not stored there.

Rated 3 out of 5 stars
By Melanie on Nov 8, 2025

CREDELIO QUATTRO

My dog was on heartguard+ until April 2025. Her heartworm tests were always negative. I switched her to this medication on May 15. I just came back from the vet

My dog was on heartguard+ until April 2025. Her heartworm tests were always negative. I switched her to this medication on May 15. I just came back from the vet yesterday withpositive heartworm results. Keira had been on this particular medication from May 15 to present. This medication obviously did not help prevent the heartworms, as I said, she is heartworm positive now. Being on a fixed income, we cannot afford to treat her for heartworms. I rated this three stars because she never had any fleas or ticks. This is way too expensive for merely treating fleas and ticks.. now I have to wonder how long I’m gonna get to enjoy my dog before the heartworms kill her.

Rated 5 out of 5 stars
By Amber on Nov 17, 2025

All in one!

This had the fastest kill rate for ticks compared to the other popular brands I was comparing to. This one is going to give you the most peace of mind while keeping

This had the fastest kill rate for ticks compared to the other popular brands I was comparing to. This one is going to give you the most peace of mind while keeping cost/value in mind. There are others that are cheaper, but this one outperformed in the areas most important to me (ticks!). But I love that it covers everything she needs all in one tablet. I broke up into 3 pieces inside some meat when giving to my dog for an easier time.

Rated 3 out of 5 stars
By Brian on Nov 16, 2025

Horrible chemical smell my dog refuses to eat, no matter what i hide it in.

Works great I guess, my dog is still healthy and none of the problems it's supposed to ward off. Just get ready to have to jam the sizeable pill down your dog's

Works great I guess, my dog is still healthy and none of the problems it's supposed to ward off. Just get ready to have to jam the sizeable pill down your dog's throat. Mine fights me like I'm trying to kill him, and that's no laughing matter since he's 90 lbs of ornery fur, teeth, and claws. I hate this time of the month for both of us.

Rated 3 out of 5 stars
By Victoria on Nov 20, 2025

Heartworm medicine

I had no problem with it. It did crush better than the last one I was using, but my dog won’t eat it. She just it out unless I crush it and put it with other food

I had no problem with it. It did crush better than the last one I was using, but my dog won’t eat it. She just it out unless I crush it and put it with other food. After being on her last heart medicine, she started to spit it out and wouldn’t chew it out, and I had to crush it and put it with the other food.

Rated 5 out of 5 stars
By Erin on Jan 1, 2026

Love Chewy Pharmacy

I recently moved and Fed-Ex didn’t want to deliver my dog’s meds. I called the pharmacy number and they called Fed Ex and had it taken care of quickly. I was im

I recently moved and Fed-Ex didn’t want to deliver my dog’s meds. I called the pharmacy number and they called Fed Ex and had it taken care of quickly. I was impressed.

Rated 5 out of 5 stars
By Betty on Nov 28, 2025

RX med

The women, at Chewy, who helped me called me to inform me there was a problem with the name of of the owner at the Laguna Madre Human. I was able to fix the problem

The women, at Chewy, who helped me called me to inform me there was a problem with the name of of the owner at the Laguna Madre Human. I was able to fix the problem and she put a quick delivery. I received it the following day.I appreciated her & Chewys.