Credelio Quattro Chewable Tablets for Dogs, 12.1-25 lbs, 6 Chewables (6-mos. supply)

Have a Chewy account?
Sign in to quickly add pet health details.
$141.15 First Time Autoship Price
this order
Save 35% (up to $90) today when you set up Autoship. 

$206.29 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Never miss a dose with easy refills
  • Skip, change, or cancel anytime
$217.15 Chewy Price
($36.20 /ea)
Promo, Save 20% on first Rx order with code RX20
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME

In Stock
FREE delivery
Usually arrives in 3-5 days
Prescription approval made easy
We’ll reach out to your vet clinic.

No interest if paid in full in 6 months. .

Medications ship separately. Delivery times may vary.

About This Item

Details

  • Credelio Quattro: The broadest1 parasite protection of its kind covering 6 types of parasites, including ticks, in one chewable tablet.
1

Based on label comparison of the number of parasite types covered in an isoxazoline endectocide. - This monthly flea and tick treatment also protects against heartworm disease and three intestinal worms that can be passed to humans – roundworms, hookworms† and tapeworms † Uncinaria stenocephala - Easy-to-Give Chewable: This FDA-approved parasite protection comes in a flavored chewable tablet that is given once a month with food or within 30 minutes of a meal. - Prescription Only: Credelio Quattro is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.

Ingredients

Instructions

FAQ

Get 6-in-1 Parasite Protection

Introducing Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) for dogs, a prescription medication that protects your dog from common parasites. Unlike other chewables, Credellio Quattro protects against 6 types of parasites, including ticks, fleas, heartworm disease and three intestinal worms that can be passed to humans – 3 species of tapeworms, roundworms and hookworms.

Protection in a Tasty Chewable

Credelio Quattro combines convenience with flavor. A beef-flavored, once-monthly tablet that makes it easy to administer. Enjoy peace of mind knowing your dog’s protection is effective and easy to give.

The Power of Four

Credelio Quattro features four tried and true active ingredients designed to combat parasites effectively. With lotilaner, moxidectin, pyrantel and praziquantel, this advanced formula provides your pet with the broadest parasite protection of its kind based on label comparison of the number of parasite types covered.

Shown To Be Safe for Dogs and Puppies

Use Credelio Quattro to help protect your dog proactively before problems happen. This preventive treatment is shown to be safe for puppies as young as 8 weeks old and weighing at least 3.3 lbs.

About Credelio Quattro

Prescription only. Ask your veterinarian if Credelio Quattro is right for your dog.

Shop Credelio

Indications

Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm, and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.

Important Safety Information

Lotilaner, an ingredient in Credelio Quattro, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, ataxia, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro administration as it is not effective against adult D. immitis. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. For complete safety information, please see the Credelio Quattro product label or ask your veterinarian.

4.6
Rated 4.6 out of 5 stars
233 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

85% Positive

Effectiveness

80% Positive

Ingredients

81% Positive

Long-Term Benefits

78% Positive

86 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Amy on Nov 4, 2025

Customer service

I had ordered the wrong credelio. When chewy called the vet for the prescription they canceled my order immediately. The vet called me with the information. Also

I had ordered the wrong credelio. When chewy called the vet for the prescription they canceled my order immediately. The vet called me with the information. Also I can have this autoshipped and it's cheaper than getting it from the Veterinary office. Thanks Chewy!


Rated 5 out of 5 stars
By jane on Jan 6, 2026

One pill for heart worm/ flea and tick

Love that I only have one pill to give monthly to protect Lily for heart worm and flea and tick. So much more convenient.

Love that I only have one pill to give monthly to protect Lily for heart worm and flea and tick. So much more convenient.


Rated 5 out of 5 stars
By Hana on Jan 9, 2026

Flea and tick protection

So far, this has been very well tolerated by both of my dogs. They took it easily and we have had no problems.

So far, this has been very well tolerated by both of my dogs. They took it easily and we have had no problems.


Rated 5 out of 5 stars
By Lynn on Dec 3, 2025

My vet loves this

My last dog was on Simparico Trio but my vet said this was better so I switched. It seems to cover more than ST and my dog has no problem with it.

My last dog was on Simparico Trio but my vet said this was better so I switched. It seems to cover more than ST and my dog has no problem with it.


Rated 5 out of 5 stars
By June on Oct 20, 2025

Will continue using credelio quatro for my pups

Easy to give appears to work. All in one dose don’t need to worry if they get wet and no side effects. This was first dose and later in year however with leaves

Easy to give appears to work. All in one dose don’t need to worry if they get wet and no side effects. This was first dose and later in year however with leaves all over worse time for ticks.


Rated 5 out of 5 stars
By Tina on Oct 12, 2025

Exceptional customer service from the pharmacist!

The pharmacist went above and beyond to straighten out a prescription issue for my puppy. She took it upon herself to speak with my veterinarian to get the problem

The pharmacist went above and beyond to straighten out a prescription issue for my puppy. She took it upon herself to speak with my veterinarian to get the problem sorted out, and make sure we had the medication in time for my puppy’s monthly dose!


Rated 1 out of 5 stars
By Kathleen on Oct 7, 2025

Will not purchase again

Dog shakes and acts drunk after taking .i have 2 pugs ,12 and 2 years old. Both dogs experienced the same symptoms drunk and shaky , wobbly . I think it’s too

Dog shakes and acts drunk after taking .i have 2 pugs ,12 and 2 years old. Both dogs experienced the same symptoms drunk and shaky , wobbly . I think it’s too strong for my pugs . So I will go back to just heartworm and flee tick separately instead of all in one.


Rated 4 out of 5 stars
By David on Nov 8, 2025

Possibly gave loose bowels for 24 hours

Doesn’t care for the taste but easily takes with peanut butter. Harmony is just over the minimum weight for this dosage so it may be a little strong for her.

Doesn’t care for the taste but easily takes with peanut butter. Harmony is just over the minimum weight for this dosage so it may be a little strong for her.


Rated 5 out of 5 stars
By Angella on Sep 29, 2025

Ease of ordering and no fleas! Whoop whoop!!

So easy to do authorship and not have to think of anything. Credelio is the best. Not even close to anything else. Love it and my pups love not having to have fleas

So easy to do authorship and not have to think of anything. Credelio is the best. Not even close to anything else. Love it and my pups love not having to have fleas. I used another medicine and they had fleas for the first time. Not anymore with Credelio.


Rated 5 out of 5 stars
By Millie on Nov 15, 2025

Credelio quatro

I was able to feed Roshen the new med today, with peanut butter. I am glad the pill is very small and Roshen didn't give me any trouble.

I was able to feed Roshen the new med today, with peanut butter. I am glad the pill is very small and Roshen didn't give me any trouble.