PancrePlus Powder for Dogs & Cats, 12-oz

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($17.38 /oz)
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About This Item

Details

PancrePlus is prescribed as a digestive aid and replacement therapy for those who have exocrine pancreatic insufficiency (EPI). EPI makes it hard or impossible for the body to digest proteins, carbohydrates and fats because the pancreas isn't producing the enzymes it should. This powder should be added to regular meals to aid in normal digestion.We directly source prescription medications from manufacturers and wholesale distributors registered with the FDA and licensed by applicable state boards. Guaranteed genuine, and where applicable, backed by the manufacturer.

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Learn More About PancrePlus From Our Team of Experts

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Also available in a [tablet form] (https://www.chewy.com/dp/173682).

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4.3
Rated 4.3 out of 5 stars
460 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

82% Positive

Ingredients

88% Positive

Long-Term Benefits

85% Positive

228 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Lucia on Jan 10, 2026

No smell

I used pancreved for years for EPI. Suddenly, the product started smelling horrible, my cat’s breath smelled horrible, his food smelled horrible and he started sneezing

I used pancreved for years for EPI. Suddenly, the product started smelling horrible, my cat’s breath smelled horrible, his food smelled horrible and he started sneezing and coughing all over the place every time he ate. I contacted the company and of course received no response. When I talked to my vet, he recommended trying PancrePlus. I generally don’t do a review in the first month of having a new product because I believe that’s useless information. I always wait until I’ve used it for a couple of months and see how it continues to work. But I have more confidence this time. I hope it continues to be a winner.

Rated 5 out of 5 stars
By Jodi on Jan 7, 2026

Professional Happy Puppy Dog

This has saved my girls life. After almost a year she had a diagnosis & started the powder she was a year old and only 33 lbs within a few months she gained her

This has saved my girls life. After almost a year she had a diagnosis & started the powder she was a year old and only 33 lbs within a few months she gained her weight that she should be at & has not lost any since -she is very healthy now. She will be on this for her life time since her pancreas does not produce the normal enzymes she’s needs in her gut to hold nutrition so prays god they never discontinue this medication because it has saved my German Shepherds life she is a walking testimony. The powder works!!! I am so thankful. The Z/D is amazing to I used it for my last shepherd used this food to & it saved her .back to health too

Rated 3 out of 5 stars
By Bonnie on Dec 13, 2025

Hope this works.

Oden has major pancreas problems. Vet recommended this product. He is feeling better and we are praying for him to recover and gain his weight back. He is a German

Oden has major pancreas problems. Vet recommended this product. He is feeling better and we are praying for him to recover and gain his weight back. He is a German shepard and weighed on 57 lbs at the start of this journey. With going only natural whole foods He is on the upswing. The only set back may be continuing with this powder as it is very expensive and I live on a very low budget . I hope this will make him well. Worth the try for my guy.

Rated 5 out of 5 stars
By Sara on Nov 12, 2025

This saved my dogs life!!

My dog got misdiagnosed for months and ended up losing more than half his weight. I was so worried he was going to pass away because the vet misdiagnosed him 2 times

My dog got misdiagnosed for months and ended up losing more than half his weight. I was so worried he was going to pass away because the vet misdiagnosed him 2 times and refused to run the test on him. Well turns out I was right and it was EPI. I wasn’t sure if this would actually work but it literally saved his life!! He gained all his weight back and is perfectly healthy again. It took about 2 months to fully work but after just 2 weeks there was a huge difference in how he acted. It’s 100% worth the money.

Rated 5 out of 5 stars
By Lyndsey on Oct 25, 2025

Works GREAT!

I love this stuff so much!! My Shepherd has EPI and so needs pancreatic enzymes. It’s tough on the mouth, so giving it directly into her food didn’t work for us

I love this stuff so much!! My Shepherd has EPI and so needs pancreatic enzymes. It’s tough on the mouth, so giving it directly into her food didn’t work for us as her gums did start bleeding. But, we put it into a powder and boom! She’s able to eat no problem, no diarrhea, no weight loss, she’s no longer starving all the time. Due to her issue she ended up like 49 lbs when she’s typically 55-60. Poor girl was just a skeleton. Now she’s back to a healthy weight and feels so much better!

Rated 1 out of 5 stars
By Robert on Oct 14, 2025

Medicine failure

So what chewy doesn't tell you about this medicine is that its shipped from Arizona and unless you get expedited shipping, the enzymes die in transit because of

So what chewy doesn't tell you about this medicine is that its shipped from Arizona and unless you get expedited shipping, the enzymes die in transit because of the heat and renders your $200 prescription useless. I'm sitting here next to my dog who is showing all the symptoms of gut fermentation because the medicine failed in transit. This is the second time this has happened and I'll be looking into a new provider here soon

Rated 1 out of 5 stars
By Brittin on Nov 15, 2025

This supplement smells awful, like a barnyard.

My vet told me the tablet equivalent to the 1/2 tsp sprinkled on my dog's meals was 12 pills per day at nearly 3 times the cost. Assuming that information is accurate,

My vet told me the tablet equivalent to the 1/2 tsp sprinkled on my dog's meals was 12 pills per day at nearly 3 times the cost. Assuming that information is accurate, the potency equivalent between the powder and the pills is bizarre.

Rated 2 out of 5 stars
By Kayla on Oct 2, 2025

Adverse reaction

Unfortunately, my vet said my pet had an allergic reaction and we had to discontinue use after less than 1 week and didnt get the results we had needed. However,

Unfortunately, my vet said my pet had an allergic reaction and we had to discontinue use after less than 1 week and didnt get the results we had needed. However, CHEWY was amazing with the outcome and assisting us with recouping the costs and reporting the reaction for future. Quick, responsive, and a bad medication reaction does not at all reflect badly on their services and I will till use them for all my pet needs.

Rated 5 out of 5 stars
By Luis on Oct 29, 2025

Saved Dogs Life

My dog was really struggling and had lost a lot of weight due to a pancreas insufficiency. This worked on the first dose and my dog gained her full healthy weight

My dog was really struggling and had lost a lot of weight due to a pancreas insufficiency. This worked on the first dose and my dog gained her full healthy weight. Expensive but worth it! Pay attention to the dosage as it can cause some irritation on the gums.

Rated 5 out of 5 stars
By Kenny on Nov 4, 2025

Grateful this medicine exists

My boy needs this enzyme which has worked well over the years. It keeps him from not getting too thin. He looks great and is healthy and happy.

My boy needs this enzyme which has worked well over the years. It keeps him from not getting too thin. He looks great and is healthy and happy.