What Does Trazodone Do for Dogs?

Trazodone is a prescription antidepressant commonly used to help dogs with short-term anxiety.  

Trazodone is generally given as a calming medication at least 90 minutes before an anxiety-inducing event. It is used as a mild sedative on an as-needed basis, but it is not as effective for dogs with chronic behavior issues who require treatment with longer-acting anti-anxiety medications. 

Trazodone for dogs is often used alone. It can be safely combined with certain medications and supplements, but not all combinations are safe—tell your veterinarian if your dog is also taking other medications or supplements. 

In certain circumstances, your vet may recommend a compounded formulation of trazodone. 

Compounded medications are prescribed if there’s a specific reason your pet’s health can’t be managed by an FDA-approved drug. Compounded medications are not FDA-approved. They are created by either a veterinarian or a licensed pharmacist on an individual basis to best suit a patient’s particular needs. 

Trazodone is a medication for humans and it is not FDA-approved for dogs. However, it can be used extra-label. This means that vets can legally prescribe certain human drugs for use in animals in certain circumstances. This is called extra-label or off-label use because this use is not described on the drug label. Speak with your vet about whether trazodone is right for your dog. 

Your vet may prescribe trazodone to help your dog stay calm in certain situations, including:  

• Separation anxiety 
• Loud, stressful situations (fireworks, thunderstorms) 
• Vet visits 
• Grooming appointments 
• After surgery, if recovery requires that your dog rest in a crate or small space 

The safest way to know the proper dose of trazodone for your dog is to ask your veterinarian.  

Follow the instructions on the label of the prescription that your vet gives you, and make sure your vet is aware of all medications or supplements your pet is taking.  

Trazodone comes in oral tablets, with the most common dosages for dogs ranging from 50 milligrams to 150 milligrams. 

If your vet orders a compounded prescription, the medication may be in liquid form.  

Your veterinarian will determine the appropriate dose of trazodone depending on your dog’s individual needs, other medications or supplements they may be taking, and their age, weight, and breed. 

Depending on your vet’s recommendation, you may need to cut pills in half or quarters at home. Try the Medline Pill Splitter, then hide the pill in a treat, like the Greenies Pill Pockets Canine Real Peanut Butter Flavor Natural Dog Treats.  

Most dogs do well on trazodone, but there are some common side effects, including:  

• Digestive upset (nausea, vomiting, or diarrhea) 
• Lethargy  
• Loss of balance  

Let your veterinarian know if your dog is experiencing side effects, and wait for their advice before giving your dog trazodone again.   

Serotonin syndrome is a rare yet serious condition that can also occur when trazodone is given with other medications or supplements that can also increase serotonin levels.  

Seek immediate emergency care if your dog is showing symptoms of serotonin syndrome:   

• Disorientation 
• Seizures   
• Lethargy 
• Agitation or nervousness  
• Muscle twitches or tremors 
• Diarrhea 
• Loss of balance or coordination  
• Fever 

Serotonin syndrome often involves multiple symptoms, but not always.  

Some symptoms of serotonin syndrome, like lethargy, can be the same as regular side effects of taking trazodone. If you have any doubts, call your veterinarian.  

It’s important to follow your vet’s dosage instructions since it is possible for dogs to ingest too much trazodone. Too much trazodone is a medical emergency. 

Symptoms of an overdose of trazodone in dogs include: 

• Lethargy  
• Loss of balance  
• Abnormal blood pressure (too high or too low) 
• Abnormal heart rate (too fast or too slow) 
• Disorientation 
• Increased skin sensitivity (hyperesthesia) 
• Urinary incontinence 
• Trouble breathing 
• Seizures 
• Muscle tremors 

If you suspect an overdose, head to the veterinarian (or an emergency vet if your regular veterinarian’s office is closed). You can call Pet Poison Helpline (855-764-7661, a fee applies) on the way there.   

While trazodone can be very helpful for dogs with anxiety issues, it’s important to follow instructions carefully and be aware of any unusual symptoms. When in doubt, call your vet.  

What does trazodone do for dogs? 

Trazodone can help dogs remain calm during anxiety-inducing events like fireworks, thunderstorms, or vet visits, as well as during bouts of separation anxiety. It should never be given without a veterinarian’s approval.  

Is trazodone safe for dogs? 

Trazodone is generally considered safe for most dogs, as long as this is under the supervision of a veterinarian. However, it is important not to mix trazodone with certain medications, and to follow the dosing instructions that your vet gives you.  

How long does it take for trazodone to work in dogs?  

While some studies suggest trazodone may work in as little as 30 minutes, most experts recommend giving it to your dog at least 90 minutes before a triggering event.  

Is dog trazodone the same as human trazodone?  

Yes. The active ingredient in trazodone for humans and dogs is the same. However, you should never give your dog a human’s medicine. Only give your dog trazodone if your vet has prescribed it for them.