Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Large Dogs

By Nutramax
Rated 4.5 out of 5 stars

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About This Item


  • Denamarin contains s-adenosylmethionine (SAMe) to help increase gluthione levels to support your dog’s liver detoxification capabilities.
  • Silybin found in Denamarin has shown better absorption in dogs than the milk thistle extract found in many other products.
  • Supporting your dog’s liver health promotes the liver’s ability to remove toxins, store energy, aid digestion and support the immune system.
  • Nutramax Laboratories Veterinary Science has made supplements to support joint health, digestive health and overall wellness for over 30 years.
  • Veterinarian formulated with high-quality ingredients to ensure supplement safety.

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Nutritional Information

Feeding Instructions


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Top IngredientsActive Ingredients: S-Adenosylmethionine, Silybin A+B.Active Ingredients: S-Adenosylmethionine, Silybin A+B.Active Ingredients: S-Adenosylmethionine, Silybin A+B.S-Adenosylmethionine 425 mg, Silybin-phosphatidylcholine complex (SPC)* 120 mg, *Providing 35 mg of Silybin A+B....Actual Ingredients: S-Adenosylmethionine.
Breed SizeMedium Breeds, Large Breeds, Giant BreedsSmall Breeds, Medium BreedsExtra Small Breeds, Small Breeds, Medium Breeds...Large BreedsMedium Breeds, Large Breeds, Giant Breeds
Health FeatureLiver CareLiver CareLiver CareLiver Care, Vitamins & MineralsLiver Care
LifestageAdult, SeniorAdult, SeniorAdult, SeniorAll LifestagesAdult, Senior
Food FormSupplementSupplementSupplementSupplementSupplement

Questions & Answers

20 Customer Questions

Can I put the tablet in a pill pocket, even though it says to give on an empty stomach? What if my dog tries to chew the tablet since it says tablet should not be split or crushed?
Answer by ChewyAug 27, 2020
While these tablets may be chewed, they do not have to be in order to be effective. This medication should be administered on an empty stomach at least 1 hour before eating. If you must mask with food it is recommended to use no more than one tablespoon.

What are side effects?
Answer by ChewyFeb 28, 2022
The active ingredients in Denamarin® have been shown to be well-tolerated by both dogs and cats with a wide margin of safety. There are no known interactions of Denamarin® with drugs or other supplements.

You suggested splitting the pills if my dog requires 2, am and pm?
Answer by ChewyOct 06, 2018
It is recommended to take the suggested dose once a day.

What is the dosage per each individual tablet?
Answer by ChewyMay 07, 2021
Denamarin Tablets for Large Dogs contain 425 milligrams of S-Adenosylmethionine and 120 milligrams of Silybin-phosphatidylcholine complex (SPC), providing 35 milligrams of Silybin A+B.

ReviewsWrite a Review

Rated 4.5 out of 5 stars
466 Ratings
Would recommend to a friend

464 Customer Reviews

Rated 2 out of 5 stars
By tehya on Sep 11, 2023

huge blue pill

Not sure why a company with over 30 years in experience would create such a large pill as a supplement. Then expect your dog to take said blue pill one hour before they eat or two hours after. My dog can smell that pill coming and refuses to take it. I have tried everything, coating it in all the things she likes and she still refuses. I should not be required to force feed her a liver supplement. It’s a supplement, make a better product.

Rated 3 out of 5 stars
By Renee on Aug 26, 2023


I’m sure this is a fantastic product that does exactly what it says but it should have a warning for side effects. After only 2 doses my dog began to experience severe gastric upset for 6 days until the vet finally had to put him on medication. I want to support my dog’s liver but his gastrointestinal system just can’t tolerate it.

Rated 5 out of 5 stars
By Nickki on Sep 19, 2023

Easy way to get your dog to eat it.

My Weimaraner won’t take pills with the pill pockets or hot dogs. I saw a review on here that they gave the pill with liverwurst. Game changer. She takes the pill no problem. Now my cat & other dog love liverwurst too. Especially my cat.

Rated 5 out of 5 stars
By AmyM on Aug 21, 2023

Great liver health boost

I've used this product previously on my canine who had liver cancer. She lived longer and with a better quality of life than expected. When we started my older large pitty on this, he seemed to have a little more pep in his step and overall felt better.

Rated 5 out of 5 stars
By Sara on Jul 29, 2023


My 13 y/o border collie has elevated liver values due to hepatitis and AIHA. This was prescribed by our vet and had helped keep his liver values in check. He probably wouldn’t still be with us without it.

Rated 5 out of 5 stars
By kfern on Jul 28, 2023

It Works!

My dog had some mildly elevated liver enzymes so my vet recommended this for 3 months. His liver values have gone down to almost normal with consistent use. It’s great despite being rather expensive.

Rated 5 out of 5 stars
By Susan on May 27, 2023

This stuff is mandatory for my pups' health

I have used Denamarin as a detoxifier for years. I was first introduced when my (now deceased) dog had elevated liver enzyme levels. It got her levels back down to a healthy range and I kept her on it for life. Now, I use Denamarin for my two younger dogs as a routine detoxifier to reduce the general chemical load (heartworm and flea meds, pesticides, etc.) I cannot avoid them being exposed to. I highly recommend!

Rated 5 out of 5 stars
By OzBoo on Aug 23, 2023

Speedy delivery

My pup had increasing liver enzymes and this was the first treatment. I received it in 2 days. I can’t say how well it works yet.

Rated 2 out of 5 stars
By HeyAshMag on May 22, 2023

Not Helping

I started this supplement three months ago for my Labrador Retriever, who is 14.5 years old. Three months ago, his levels were 50% less than they were today when I had his labs re-tested. I will be discontinuing this supplement as I don't feel it's doing anything, and that it could actually be working the opposite way it's meant to for my sweet boy. Not blaming the med, but rather my dog's body and how things function for him.

Rated 5 out of 5 stars
By LoveMyFurbabies on Sep 3, 2023


My vet prescribe this for my dog who has high ALT levels. This brand crushes easily so I can mix it in his food.