Nutramax Denamarin with S-Adenosylmethionine & Silybin Chewable Tablets Liver Supplement for Dogs

By Nutramax
Rated 3.6184 out of 5 stars


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$44.99Chewy Price
$42.74Autoship Price
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About This Item


  • Denamarin contains s-adenosylmethionine (SAMe) to help increase your dog’s glutathione levels and support his liver’s detoxification capabilities.
  • Silybin found in Denamarin has shown better absorption in dogs than the milk thistle extract found in many other products.
  • Supporting your dog’s liver health promotes the liver’s ability to remove toxins, store energy, aid digestion and support the immune system.
  • Nutramax Laboratories Veterinary Science has made supplements to support joint health, digestive health and overall wellness for over 30 years.
  • Veterinarian formulated with high-quality ingredients to ensure supplement safety.

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Nutritional Information

Feeding Instructions


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Top IngredientsActive Ingredients: S-Adenosylmethionine, Silybin A+B.Active Ingredients: S-Adenosylmethionine, Silybin A+B.Active Ingredients: S-Adenosylmethionine, Silybin A+B.S-Adenosylmethionine 225 mg, Silybin-phosphatidylcholine complex (SPC)* 82 mg, *Providing 24 mg of Silybin A+B....S-Adenosylmethionine 90 mg, Silybin-phosphatidylcholine complex (SPC)* 31 mg, *Providing 9 mg of Silybin A+B....
Breed SizeExtra Small Breeds, Small Breeds, Medium Breeds...Small Breeds, Medium Breeds, Large BreedsSmall Breeds, Medium Breeds, Large BreedsMedium BreedsSmall Breeds
Health FeatureLiver CareLiver CareLiver CareLiver Care, Vitamins & MineralsLiver Care, Vitamins & Minerals
LifestageAdult, SeniorAdult, SeniorAdult, SeniorAll LifestagesAll Lifestages
Food FormSupplementSupplementSupplementSupplementSupplement

Questions & Answers

17 Customer Questions

What flavor are these?
Answer by ChewyJul 25, 2018
This supplement is pork liver flavored.

How large are the pills? Could you give me a measurement of the diameter?
Answer by ChewyDec 21, 2017
The supplement is about the size of a dime with a diameter of 0.705 inches.

Can this be crushed and put in a pill pocket, even though it says to take on an empty stomach?
Answer by ChewyAug 27, 2020
While these tablets may be chewed, they do not have to be in order to be effective. This medication should be administered on an empty stomach at least 1 hour before eating. If you must mask with food it is recommended to use no more than one tablespoon.

Is this product Made in the USA?
Answer by ChewyDec 03, 2020
This supplement is manufactured in Lancaster, South Carolina.

ReviewsWrite a Review

Rated 3.6184 out of 5 stars
642 Ratings
Would recommend to a friend

632 Customer Reviews

Rated 3 out of 5 stars
By James on Nov 29, 2023

Difficult to feed

The hard chalky nature of these tablets makes them a problem to feed to my dog. The flavor must be OK because he’ll take them in his mouth but as soon as he crunches it, he spits it out because it’s very hard and dry. I have to put it in a pill pocket, defeating the purpose of giving on an empty stomach for best absorption.

Rated 1 out of 5 stars
By Bobbie on Nov 17, 2023


Denamarin was recommended by our vet to protect our Goldendoodle’s liver. We tried, and she tried but she couldn’t chew it. Too hard to bite. She couldn’t swallow it. Too big to swallow whole. She couldn’t stand the taste when we broke it up. Is this the only form available.

Rated 1 out of 5 stars
By CRAIG on Nov 13, 2023

Nutramax SAMe is overpriced, and my dog won't chew it

Finding this to be yet another overpriced supplement- readily available to humans- and the for human consumption products have better labeling of what's in it! I consider Nutramax to be gouging the "for pets" market. I will be returning the unopened bottle for refund

Rated 1 out of 5 stars
By Keith on Nov 13, 2023

Denamarin Chewables - Too big

I had hoped these chewables would be an easy way to administer Denamarin to our dog. But the tablets are way too big and even when we break them, he won't eat them. He eat's everything but he won't touch these. I don't recommend them. Now I need to buys the pills.

Rated 3 out of 5 stars
By Cocinelle on Sep 29, 2023

Bitter taste

I called the manufacturer, because my dog, a huge chowhound, wouldn’t eat them. He acts like other chewables, flea/tick, heartworm, Cosequin etc are treats. I was pretty surprised but the manufacturer said it has a bitter taste, so that explains it. They do offer another formulation, called Denamarin pro, I believe, that uses a more concentrated active ingredient (reducing the bitterness) but it is only available from vets and is way more expensive. I had put this on autoship, thinking it would be a great alternative to the pills, but unfortunately, my dog said no.

Rated 3 out of 5 stars
By Allison on Oct 14, 2023

Dog won’t eat them

I have to coat them in a bit of peanut butter or she won’t eat them. And she’ll usually eat anything. They’re supposed to be taken on an empty stomach, at least an hour before food, so I hope this isn’t negating some of their benefit. Also, my dog is about 65 lbs, so her dose is 2.5 tablets per day, meaning she goes through them fast.

Rated 4 out of 5 stars
By Kristen on Sep 10, 2023

A little inconvenient

My vet recommended this for our poodle mix. She won’t eat it by itself but if I put it in a pill pocket she wolfs it right down. We have not had a retest to see if it works on her liver values. The one thing I don’t like about it is that the dog has to take it one hour before a meal, so you have to plan ahead. This is really inconvenient, especially if you’re not home an hour before feeding time; the dog is then starving and has to wait longer to eat. I wish there were something you could give with meals - maybe make it a time release med and not a chew? From the reviews it sounds like most dogs hate the taste anyway. We will continue it at our vet’s advice until I find a better alternative - and there may not be one.

Rated 3 out of 5 stars
By Debbie on Oct 31, 2023

Not as Good as Advanced version

I wish the Advanced version of the denamarin was more readily available. The regular tablet is huge and not very yummy (at least according to my 20lb dog). The Advanced tablet is not only smaller but my dog only needs to take 1/2 of it to get the same benefit.

Rated 1 out of 5 stars
By Diane on Nov 16, 2023

Dog refused

Unfortunately my dog refused to eat them. I was hoping she would like them as I have the regular pills that I have to disguise in a small amount of wet food. Was hoping the chewable would work.

Rated 5 out of 5 stars
By Jacquelynn on Sep 7, 2023

Liver enzymes level back to normal

My fur baby was sick from a tick bite which brought on a high fever and elevated liver enzyme levels. Caught everything in time and the vet recommended Nutramax Denamarin which helped and was amazing she is staying on them her numbers are normal. Easy to give and and easy for her to chew. Just follow the directions. She will be using them always. Hopefully other babies will benefit from this. I also think this is a good supplement to take. Ask your vet about these.