Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

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  • All Lifestages
  • Large Breeds

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About This Item

Details

  • Support your dog’s liver health with veterinarian-recommended Denamarin.
  • Denamarin for dogs contains S-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione—one of the liver’s main detoxifying agents.
  • The silybin (a bioactive component of milk thistle extract) found in Denamarin is more bioavailable than standardized milk thistle extract.
  • The liver, one of your pet’s most vital organs, is responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system.
  • Denamarin undergoes thorough quality inspections to ensure your dog receives a safe, high-quality product.

Ingredient Information

Instructions

FAQ

Learn More About Nutramax From Our Team of Experts

Combined Power of SAMe and Silybin

Denamarin combines the power of S-adenosylmethionine (SAMe) and silybin to help support healthy liver function in pets.

#1 Veterinarian Recommended

Denamarin is the #1 veterinarian recommended liver support brand.

*Survey conducted among small animal veterinarians who recommended liver support supplements.

The Denamarin Difference

The Silybin (a bioactive component of milk thistle extract) found in Denamarin is more bioavailable than standardized milk thistle.

Unmatched Quality

Each batch of Cosequin undergoes rigorous quality inspections, ensuring that your pet receives a high-quality joint health supplement.

About Nutramax

Family owned and operated since 1992, Nutramax Laboratories exceeds the industry standard for animal health supplements. We develop high-quality products for joint, liver, digestive health, and overall wellness.

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Questions & Answers

20 Customer Questions

Is this a chewable tablet?

Answer by Chewy • Jun 05, 2022
These tables are chewable.

What is the dosage per each individual tablet?

Answer by Chewy • May 07, 2021
Denamarin Tablets for Large Dogs contain 425 milligrams of S-Adenosylmethionine and 120 milligrams of Silybin-phosphatidylcholine complex (SPC), providing 35 milligrams of Silybin A+B.

You suggested splitting the pills if my dog requires 2, am and pm?

Answer by Chewy • Oct 06, 2018
It is recommended to take the suggested dose once a day.

Are these enteric coated?

Answer by Chewy • Jun 19, 2020
Nutramax Denamarin Tablets for Large Dogs are enteric-coated tablets in blister packaging.
Reviews
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4.6
Rated 4.6 out of 5 stars
1828 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

82% Positive

Effectiveness

85% Positive

Ingredients

81% Positive

Long-Term Benefits

85% Positive

817 Customer Reviews

Rated 5 out of 5 stars
By Ellen on Jan 5, 2026

Chewy, of course, sent it in a box.

This is very important for dogs with elevated liver enzymes. There is only one med Rosy is prescribed that Chewy does not carry, and the vendor persists in mailing

This is very important for dogs with elevated liver enzymes. There is only one med Rosy is prescribed that Chewy does not carry, and the vendor persists in mailing it in padded envelopes so the packages arrive squashed flat. It makes me love Chewy even more, because I don’t have to tell you to box my meds. Everything is boxed when it comes from Chewy. This little jar of Denamarin came in a box, with lots of paper padding. It sad how’s that somebody at Chewy cares.

Rated 5 out of 5 stars
By Michelle on Jan 14, 2026

Helping our daughter’s liver

Mya has had higher than normal liver counts that made all of us including her vet very concerned. Due to another medical problem, we were able to se how well this

Mya has had higher than normal liver counts that made all of us including her vet very concerned. Due to another medical problem, we were able to se how well this medication worked lowering her levels drastically! We are highly impressed!

Rated 4 out of 5 stars
By Christy on Jan 1, 2026

My pup took this right out of my hand!

My Vet recently told me to give this to my pup to see if it would lower her elevated ALP score. I can’t speak to that yet but I wanted to say that she eats it whole

My Vet recently told me to give this to my pup to see if it would lower her elevated ALP score. I can’t speak to that yet but I wanted to say that she eats it whole. No problems there. I give it to her an hour before breakfast. Will report back in once she is retested. Maybe the product gets its fifth star then.

Rated 4 out of 5 stars
By Amanda on Jan 5, 2026

Great product

This supplement assists my senior dog with liver failure. I feel like it’s given her more time with us. The only issue is I wish the chewable was offered instead

This supplement assists my senior dog with liver failure. I feel like it’s given her more time with us. The only issue is I wish the chewable was offered instead of the pill-we have a hard time getting her to take it-even wi try treats she picks it out but no issues with the chewable version.

Rated 1 out of 5 stars
By Christopher on Nov 26, 2025

Large Pill, Hard to Give

These pills are LARGE and supposed to be given on an empty stomach, which makes them very difficult to give. After only two days of having to force them down my

These pills are LARGE and supposed to be given on an empty stomach, which makes them very difficult to give. After only two days of having to force them down my dog's throat, I gave up. There's no way the manufacturer thought this through or even has dogs of their own. They're supposedly enteric coated, which means they shouldn't be chewed or broken up in any way, meaning the only way to give them is through force unless somehow you have a dog that will swallow anything.

Rated 3 out of 5 stars
By Katherine on Nov 5, 2025

Difficult to administer to my senior dog and made him nauseated

I fully realize Denamarin is the standard of care for dogs with elevated liver enzymes, and if pet owners can make it work for their dog, I'd definitely stick with

I fully realize Denamarin is the standard of care for dogs with elevated liver enzymes, and if pet owners can make it work for their dog, I'd definitely stick with it. But for my dog, since it's supposed to be given on an empty stomach, I had to cram a large pill down my senior boy's throat every morning, as he refused to eat the chewable version. Getting the pill down him got progressively more difficult, it got to the point where it was just a huge battle we both dreaded. Also, about half the time I got the pill into him, he'd vomit within a half an hour. It clearly was making him nauseated, as he started refusing his food as well. So I finally quit giving it to him and switched to a liver supplement without SAM-e, which can be given in a pill pocket with food. I'm guessing it's not as effective, but the Denamarin just wasn't going to work for him.

Rated 1 out of 5 stars
By Erika on Nov 18, 2025
Top 500 Contributor

Liver supplement

I purchased this for my senior dog after reading up on heartworms and high ALP. My senior girl was diagnosed heartworm positive and I’m doing the slow kill method

I purchased this for my senior dog after reading up on heartworms and high ALP. My senior girl was diagnosed heartworm positive and I’m doing the slow kill method since she’s 13.5 years old and was paralyzed a year ago from IVDD. The treatment would be too hard for her. I gave her these pills for 4 days and she vomited the next morning every single day. I discontinued them. Important to note that they go bad after 30 days once you open it too. It didn’t work for us but hopefully for others!

Rated 4 out of 5 stars
By Cheri on Dec 16, 2025

Required by Our Vet

My dog Grace is 15 yrs old and is a German Shepherd mix. In the past year she has had some joint issues and was prescribed Carprofen. This medicine causes liver

My dog Grace is 15 yrs old and is a German Shepherd mix. In the past year she has had some joint issues and was prescribed Carprofen. This medicine causes liver problems so our vet wants her to take Denanarin to help with her liver. I gave it 4 stars because it is expensive (around $75).

Rated 5 out of 5 stars
By Angela on Nov 9, 2025

Quick delivery

My order arrived quickly, as always with Chewy, thank you! I purchased Denamarin for my dog, and while the product seems good, she isn’t a big fan of the pill’s

My order arrived quickly, as always with Chewy, thank you! I purchased Denamarin for my dog, and while the product seems good, she isn’t a big fan of the pill’s taste. It definitely takes a little creativity to get her to take it! I’ve found that wrapping it in a small bit of sweet potato works best, especially since the directions say it should be given on an empty stomach unless otherwise advised by a vet. Overall, I appreciate the fast delivery and the clear product information.

Rated 5 out of 5 stars
By Tami on Dec 12, 2025

I was skeptical but it works

This product was recommended by my vet because of elevated liver enzymes. This product is not inexpensive but the health of my dog is worth it and to my surprise

This product was recommended by my vet because of elevated liver enzymes. This product is not inexpensive but the health of my dog is worth it and to my surprise his last blood test all of this liver enzymes were back in range.