PancrePlus Powder for Dogs & Cats, 8-oz

Have a Chewy account?
Sign in to quickly add pet health details.
Skip image gallery
Slide 1 of 4

$137.86 First Time Autoship Price
this order
Save 35% (up to $20) today when you set up Autoship. 
$149.97 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Never miss a dose with easy refills
  • Skip, change, or cancel anytime
$157.86 Chewy Price
($19.74 /oz)
Promo, Save 20% on first Rx order with code RX20
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME
In Stock
FREE delivery
Usually arrives in 3-5 days
Prescription approval made easy
We’ll reach out to your vet clinic.

No interest if paid in full in 6 months. .

Medications ship separately. Delivery times may vary.

About This Item

Details

PancrePlus is prescribed as a digestive aid and replacement therapy for those who have exocrine pancreatic insufficiency (EPI). EPI makes it hard or impossible for the body to digest proteins, carbohydrates and fats because the pancreas isn't producing the enzymes it should. This powder should be added to regular meals to aid in normal digestion.We directly source prescription medications from manufacturers and wholesale distributors registered with the FDA and licensed by applicable state boards. Guaranteed genuine, and where applicable, backed by the manufacturer.

Ingredients

Instructions

FAQ

Learn More About PancrePlus From Our Team of Experts

Shop Veterinary Diet Food, Supplements, Dental Care & More alt text
Also available in a [tablet form] (https://www.chewy.com/dp/173682).

Frequently bought together

Reviews
Write a Review
4.4
Rated 4.4 out of 5 stars
468 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

85% Positive

Effectiveness

83% Positive

Ingredients

89% Positive

Long-Term Benefits

85% Positive

231 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Lucia on Jan 10, 2026

No smell

I used pancreved for years for EPI. Suddenly, the product started smelling horrible, my cat’s breath smelled horrible, his food smelled horrible and he started sneezing

I used pancreved for years for EPI. Suddenly, the product started smelling horrible, my cat’s breath smelled horrible, his food smelled horrible and he started sneezing and coughing all over the place every time he ate. I contacted the company and of course received no response. When I talked to my vet, he recommended trying PancrePlus. I generally don’t do a review in the first month of having a new product because I believe that’s useless information. I always wait until I’ve used it for a couple of months and see how it continues to work. But I have more confidence this time. I hope it continues to be a winner.

Rated 5 out of 5 stars
By Jodi on Jan 7, 2026

Professional Happy Puppy Dog

This has saved my girls life. After almost a year she had a diagnosis & started the powder she was a year old and only 33 lbs within a few months she gained her

This has saved my girls life. After almost a year she had a diagnosis & started the powder she was a year old and only 33 lbs within a few months she gained her weight that she should be at & has not lost any since -she is very healthy now. She will be on this for her life time since her pancreas does not produce the normal enzymes she’s needs in her gut to hold nutrition so prays god they never discontinue this medication because it has saved my German Shepherds life she is a walking testimony. The powder works!!! I am so thankful. The Z/D is amazing to I used it for my last shepherd used this food to & it saved her .back to health too

Rated 3 out of 5 stars
By Bonnie on Dec 13, 2025

Hope this works.

Oden has major pancreas problems. Vet recommended this product. He is feeling better and we are praying for him to recover and gain his weight back. He is a German

Oden has major pancreas problems. Vet recommended this product. He is feeling better and we are praying for him to recover and gain his weight back. He is a German shepard and weighed on 57 lbs at the start of this journey. With going only natural whole foods He is on the upswing. The only set back may be continuing with this powder as it is very expensive and I live on a very low budget . I hope this will make him well. Worth the try for my guy.

Rated 5 out of 5 stars
By Jenifer on Jan 22, 2026

It WORKS!!!

Takes a little tweaking, but once you find your correct ratio, your pup will be on their way. Look up Epi4Dogs Foundation, Inc. if you are new to this and need some

Takes a little tweaking, but once you find your correct ratio, your pup will be on their way. Look up Epi4Dogs Foundation, Inc. if you are new to this and need some good insight.

Rated 5 out of 5 stars
By Sara on Nov 12, 2025

This saved my dogs life!!

My dog got misdiagnosed for months and ended up losing more than half his weight. I was so worried he was going to pass away because the vet misdiagnosed him 2 times

My dog got misdiagnosed for months and ended up losing more than half his weight. I was so worried he was going to pass away because the vet misdiagnosed him 2 times and refused to run the test on him. Well turns out I was right and it was EPI. I wasn’t sure if this would actually work but it literally saved his life!! He gained all his weight back and is perfectly healthy again. It took about 2 months to fully work but after just 2 weeks there was a huge difference in how he acted. It’s 100% worth the money.

Rated 5 out of 5 stars
By Jim on Jan 20, 2026

Great Service and Products

I was impressed by the way the customer service rep connected with the Pharmacist to efficiently and effectively get me the right product for my Bengal cat. I love

I was impressed by the way the customer service rep connected with the Pharmacist to efficiently and effectively get me the right product for my Bengal cat. I love Chewy!!

Rated 5 out of 5 stars
By Lyndsey on Oct 25, 2025

Works GREAT!

I love this stuff so much!! My Shepherd has EPI and so needs pancreatic enzymes. It’s tough on the mouth, so giving it directly into her food didn’t work for us

I love this stuff so much!! My Shepherd has EPI and so needs pancreatic enzymes. It’s tough on the mouth, so giving it directly into her food didn’t work for us as her gums did start bleeding. But, we put it into a powder and boom! She’s able to eat no problem, no diarrhea, no weight loss, she’s no longer starving all the time. Due to her issue she ended up like 49 lbs when she’s typically 55-60. Poor girl was just a skeleton. Now she’s back to a healthy weight and feels so much better!

Rated 5 out of 5 stars
By Maria on Jan 23, 2026

Quickness

I wish this would be discounted for me as I buy it on a regular basis instead of getting a gift card for spending over $100.

I wish this would be discounted for me as I buy it on a regular basis instead of getting a gift card for spending over $100.

Rated 1 out of 5 stars
By Robert on Oct 14, 2025

Medicine failure

So what chewy doesn't tell you about this medicine is that its shipped from Arizona and unless you get expedited shipping, the enzymes die in transit because of

So what chewy doesn't tell you about this medicine is that its shipped from Arizona and unless you get expedited shipping, the enzymes die in transit because of the heat and renders your $200 prescription useless. I'm sitting here next to my dog who is showing all the symptoms of gut fermentation because the medicine failed in transit. This is the second time this has happened and I'll be looking into a new provider here soon

Rated 1 out of 5 stars
By Brittin on Nov 15, 2025

This supplement smells awful, like a barnyard.

My vet told me the tablet equivalent to the 1/2 tsp sprinkled on my dog's meals was 12 pills per day at nearly 3 times the cost. Assuming that information is accurate,

My vet told me the tablet equivalent to the 1/2 tsp sprinkled on my dog's meals was 12 pills per day at nearly 3 times the cost. Assuming that information is accurate, the potency equivalent between the powder and the pills is bizarre.