Sileo Oromucosal Gel for Dogs, 0.09 mg/mL, 3 mL
Prescription Item
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Sileo (dexmedetomidine oromucosal gel) is the first and only FDA-approved treatment for dogs that suffer from noise aversion. This medication is prescribed by your veterinarian to help calm your dog when your pet is frightened by loud noises. Common noise aversion triggers include fireworks, thunder, construction work, traffic or street noise, celebrations, vacuum cleaners and smoke detectors. Sileo works by blocking norepinephrine, a brain chemical similar to adrenaline that pumps up anxiety.
UsesSileo treats dogs suffering from noise aversion, excessive fear, and anxiety caused by loud noises.
Possible Side EffectsNo serious adverse reactions are attributed to the administration of dexmedetomidine oromucosal gel in dogs.
Drug & Food InteractionsSileo should not be administered in the presence of pre-existing hypotension, hypoxia, or bradycardia. Sensitive dogs may experience a drop in body temperature and heart rate. These dogs should be kept warm and not offered food or water until Sileo's effects have worn off (usually within a few hours). Do not use in dogs sedated from previous dosing.
Precautions
If Sileo is swallowed, do not repeat the dose for at least two hours. Feeding and giving treats within 15 minutes after administration should be avoided. The use of other central nervous system depressants may potentiate the effects of Sileo. Sileo has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival diseases. Sileo has also not been evaluated for aversion behaviors to thunderstorms. Administration to pregnant dogs may induce uterine contractions and/or decrease fetal blood pressure. Not for human use. Keep out of reach of children. Avoid administering the product if pregnant, as exposure may induce uterine contractions and/or decrease fetal blood pressure. Appropriate precautions should be taken while handling and using filled syringes. Impermeable disposable gloves should be worn when handling the syringe, administering Sileo, or when coming in contact with the dog's mouth after application.
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Item Number146296
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Common Brand Name(s)Sileo, Dexdomitor
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For Use WithDogs
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Generic NameDexmedetomidine Oromucosal
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Administration FormOromucosal
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BrandZoetis
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Product FormGel
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Health ConditionAnxiety
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Drug TypeSedative
Dexmedetomidine Oromucosal Gel.
Sileo is administered onto the lining of the mouth by placing the gel between your dog’s cheek and gums, allowing for transmucosal absorption. Since the gel is absorbed through the skin, it should not be swallowed by your dog. If the gel is swallowed, the product may not be effective and do not repeat the dose for at least two hours. A dose greater than 6 dots should be divided evenly between both sides of the mouth. Use gloves in the administration of Sileo. The dosing chart is by body weight and associated number of dots. Each dot is 0.25 mL; 4 dots is equivalent to 1 mL. See instructional video above for more detailed instructions.
Storage InstructionsStore opened and unopened syringes in the original package at controlled room temperatures of 68° - 77°F. Use contents within 4 weeks after opening the syringe.
What is Sileo?
Sileo is the first and only FDA-approved treatment for canine noise aversion associated with fear and anxiety. Sileo has been proven to work on its own without other treatments or training.
What are the benefits of Sileo Gel?
- Fast-acting and easy to administer.
- Helps treat your dog's anxiety due to loud noises such as fireworks and thunder.
How does Sileo work?
Sileo is formulated as a gel that is absorbed into your dog’s body when you apply it to the mucous membranes between your dog’s cheek and gums. Dexmedetomidine (the active ingredient) calms your dog by preventing or reducing specific reactions in the nervous system.
What is noise aversion?
Noise aversion is the set of anxiety- or fear-based behaviors that dogs can display when subjected to “noise triggers.”
What is included in my supply of Sileo?
Sileo is supplied in a 3-milliliter oral syringe. Each syringe comes with a dosing ring and end cap along with a prescribing information leaflet.
Why should a dose greater than 6 dots be divided between both sides of the mouth?
Six dots is equivalent to 1.5 mL, a dose volume that is too great to administer effectively to one side of the mouth without the risk of some of the dose being swallowed or flowing out of the mouth. Administering half of the dose on one side of the mouth and half on the other side maximizes absorption through the mucous membranes.
What if my dog receives more than the required dose of Sileo? Much of the excess gel may flow out of the mouth or be swallowed, which would limit the effects on your dog. In a worst case scenario where the entire syringe (3 mL) is accidentally applied to a smaller dog and is fully absorbed, mild to moderate sedation may occur. As always, contact your veterinarian in any situation where you feel your dog has received too much of the prescribed medication.
How should any empty syringes or unused Sileo be disposed?
State and federal medical waste laws apply. The easiest method could be to place the used syringe back into the box and return it to the veterinary clinic. Ask your veterinarian about proper disposal of empty or partially used Sileo syringes.
Can Sileo be administered without using the syringe provided?
No. This will cause incorrect dosing. (Also, remember to wear impermeable gloves; see more in the Human Safety questions below.)
Can a partially used syringe be reused for additional doses?
Yes, within two weeks, but only if there is enough gel remaining for a complete dose (to minimize the risk of incorrect dosing).
Why are impermeable disposable gloves required for administration of Sileo?
Although dexmedetomidine (the active ingredient in Sileo) cannot be absorbed through intact skin, it can be absorbed through breaks in the skin and through mucous membranes. Therefore, as a precaution, you should wear impermeable disposable gloves when administering SILEO to your dog.
What if I'm exposed to Sileo?
In the case of accidental exposure to the skin, the area should be immediately and thoroughly washed; remove contaminated clothing and contact your physician if you have questions.If Sileo comes in contact with your eyes, nose or mouth, it can be absorbed into your body, so you should flush the exposed area with water for 15 minutes. If you are wearing contact lenses, flush the eyes and then remove contact lenses and continue flushing; seek medical advice immediately. If the drug is absorbed into your body, it can cause symptoms such as lowered blood pressure (which may result in dizziness, fainting, lack of concentration, blurred vision, nausea, cold, clammy or pale skin, rapid, shallow breathing), sleepiness and slower heart rate. Share package information with your physician and tell him/her that SILEO contains an alpha-2 adrenoceptor agonist.
Customer Reviews
95% Recommend
95% of reviewersrecommend this product
You've Already Reviewed This Item
58 Reviews
Showing 1-10 of 58 Reviews
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mixed review
By lizzie on Jan 12, 2021
I tried this product last summer. My dog is terrified of thunder storms. Problem with this product and others for thunder is that you have to give it 1 hour ahead. That's not possible. Storms come up so fast. Now I am using it for car anxiety. I used it one time for a 45 minute car ride and he was good for the first 20 minutes. After that the shaking and whining started. He did not drool however. I'll try again with it. I really want it to work.
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Really not sure
By Hotface369 on Dec 14, 2020
My puppy is crazy specially when going to the vet, I have her this medication yes she did went to sleep but I don’t know if it was the medication or it was just her nap time
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Works Amazin' for our Brazen
By Chinamom on Jul 25, 2020
Sileo was recommended by our vet earlier this year after inquiring if there was something new on the market that would ease her anxiety and fear of thunderstorms and fireworks. During these episodes our JRT trembles, pants, will not eat and is inconsolable. This is a gel that is administered between the dog's cheek and gum line. This should be done correctly since if it is dosed into the mouth and swallowed it will not be effective. We were pleasantly surprised at the result of this drug. After approximately a half an hour after giving our dog Sileo she become relaxed but not drugged or groggy. She later ate her evening meal with no problem and slept normally throughout the night. The next Sileo was recommended by our vet earlier this year after inquiring if there was something new on the market that would ease her anxiety and fear of thunderstorms and fireworks. During these episodes our JRT trembles, pants, will not eat and is inconsolable. This is a gel that is administered between the dog's cheek and gum line. This should be done correctly since if it is dosed into the mouth and swallowed it will not be effective. We were pleasantly surprised at the result of this drug. After approximately a half an hour after giving our dog Sileo she become relaxed but not drugged or groggy. She later ate her evening meal with no problem and slept normally throughout the night. The next morning she was bright and her usual active self on her morning walk. We are so glad that we were recommended to try Sileo since this has been the only drug that we found that actually eases our dog's anxiety. … more
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Great stuff!
By Docadaughter45 on Aug 31, 2020
This was recommended by my veterinarian (prescription needed). It works great. Our Attie has gotten extremely sensitive to thunderstorms, loud noises, fireworks,even the base on a radio! She has always been a little freaky for thunderstorms but due to the extreme and constant use of fireworks this year she has become super sensitive. It is so sad to watch her. We tried this Sileo and, within 15 minutes, you could see that it was working and she was beginning to relax. She was still a bit apprehensive but getting mellow. She began to relax even more and eventually laid down and went to sleep. The medication lasts for about 2 hours but even then, it is a gradual wearing off. We will not This was recommended by my veterinarian (prescription needed). It works great. Our Attie has gotten extremely sensitive to thunderstorms, loud noises, fireworks,even the base on a radio! She has always been a little freaky for thunderstorms but due to the extreme and constant use of fireworks this year she has become super sensitive. It is so sad to watch her. We tried this Sileo and, within 15 minutes, you could see that it was working and she was beginning to relax. She was still a bit apprehensive but getting mellow. She began to relax even more and eventually laid down and went to sleep. The medication lasts for about 2 hours but even then, it is a gradual wearing off. We will not be without this medication. It really is helping her - and us! … more
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Best I’ve Found
By JohnP on Jul 4, 2020
This was recommended by my vet. After some research I saw that it’s the same medication given to ICU patients for anxiety. It’s safe, effective and easy to give. It comes as a gel in a syringe that you can adjust for dosage and then squirt it up between the gums and upper lip. It calms my greyhound just enough that she will actually drift asleep, until the next loud thunder clap but is less reactive to it. With all the fireworks currently as well as summer thunderstorms this is a lifesaver.
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May not be suitable for all dogs
By Kbeth on Jul 27, 2020
This product was very effective in minimizing fear during storms. However, after the first use, my service dog's stool became unusually soft. After the second use 4 days later, she was calm until she began vomiting. It could be a sensitive digestive issue, which is not true for all dogs. I recommend its use with caution.
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Finally something that works!!
By Beca on Jul 6, 2020
My little one is 12 lbs and the dosage was 2 dots but I started with a little less than one. Gave her some half an hour before bed time and she did amazing!! No shaking, no panting or nervousness. It seems to last, at least for her, 2 nights with the one dose. Also, she did wake up a few times but just to reposition herself and was still not affected by the fireworks. SO HAPPY THIS WORKED!!
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Like taking a sugar pill
By Buckleysmom on Jul 7, 2020
This was something the vet tried my dog on after several medications and CBD oils as well as other things did not work for her. This did absolutely nothing for her. She is terrified of fireworks and thunder and this medication was like giving her a sugar pill. I gave it just like the vet told me at least two to three hours before the incident and even gave her a second dose two and a half hours after I gave her the first just to make sure it would be in her system well. If I could give this a zero I would. This is something I will not ever try again and I advise people that want to try this for your dog if they have moderate to severe anxiety that you do not try this because it will not work. This was something the vet tried my dog on after several medications and CBD oils as well as other things did not work for her. This did absolutely nothing for her. She is terrified of fireworks and thunder and this medication was like giving her a sugar pill. I gave it just like the vet told me at least two to three hours before the incident and even gave her a second dose two and a half hours after I gave her the first just to make sure it would be in her system well. If I could give this a zero I would. This is something I will not ever try again and I advise people that want to try this for your dog if they have moderate to severe anxiety that you do not try this because it will not work. … more
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Excellent new product
By Lulugrl on Sep 5, 2020
We used to give our anxious dog a pill when there were storms/fireworks but it took So long to take effect. The Sileo gel is easy to use and takes effect very quickly. Fantastic product.
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Worked wonders
By Kath68911 on Aug 5, 2020
I was a little skeptical about this product someone have recommended it to me and I can't believe I have not use this product sooner my poor dog has been suffering for 10 years with thunderstorms and fireworks and after administering this she is calm and not frightened that all it's a miracle drug another thing to note is she was not dopey and incoherent like other drugs have made her in the past highly recommend
