Vetoquinol Zylkene Equine Behavior Support Apple Flavor Powder Horse Supplement 2000 mg, 20 count

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About This Item

Details

  • The only veterinary supplement formulated with alpha-casozepine, a natural cow’s milk protein known to effectively help relax horses and ponies.
  • Non-drowsy formula provides a sense of calm while maintain mental alertness, without tranquilizing or sedating effects.
  • Perfect to use for all stressful situations your horse may encounter, on or off the farm, and is backed by research for behavior management.
  • Free of lactose and preservatives, so it’s ideal for horses with sensitives; chosen by veterinarians and dog behaviorists for short-term or long-term use.
  • Easy to give once daily at meal time, with an apple flavor that most horses love.

Ingredient Information

Feeding Instructions

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Questions & Answers

4 Customer Questions

How long does the calming effect last after dosing?

Answer by Chewy • Mar 17, 2024
This supplement can last anywhere from 6-12 hours. It mainly depends on the individual horse's metabolism and how stimulated they might get from a certain stimulant.

Do you need a Prescription to purchase this product.

Answer by Chewy • Aug 12, 2018
A prescription is not required to purchase this supplement powder.

How long after administration does it take effect? Can it be used on a case by case basis? (i.e. farrier visit)

Answer by Chewy • Oct 22, 2018
It could take 1-2 hrs. before you can see an effect. This depends on sex, age and metabolism of the individual horse. It can be used for specific events only.

What is the active ingredient?

Answer by Chewy • Jul 04, 2023
The Active Ingredients Per Packet (8 grams) are as follows: Hydrolyzed Milk Protein (Bovine) Providing Alpha-Casozepine, 2000 milligrams. The Inactive Ingredients are Apple flavor and Maltodextrin.
Reviews
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4.2
Rated 4.2 out of 5 stars
61 Ratings
Terms & Conditions

45 Customer Reviews

Rated 4 out of 5 stars
By Kaitlin on Oct 10, 2025
Received Free Product

Easy to use, somewhat mixed results

This item comes pre-packaged in packets of servings with smaller horses/ponies getting 1 packet per serving and larger horses getting 2 packets. Instructions are

This item comes pre-packaged in packets of servings with smaller horses/ponies getting 1 packet per serving and larger horses getting 2 packets. Instructions are simple and clearly marked on the packaging. It's maybe about a teaspoon worth of powder, so easy to mix into feed for the horses to eat. It doesn't really have a smell, but is supposedly apple flavor. I tried it on three horses with somewhat mixed results - 2 horses definitely seemed more chill after following the serving size per the 3 day course, and 1 didn't seem to be phased. I'd definitely use this product again for the horses I know it works on as it just seems to level them out without making them a deadhead.

Rated 5 out of 5 stars
By Heather W on Oct 16, 2025
Received Free Product

Definitely takes the edge off without sedatives!

Zylkene worked well for our flighty weanling. She didn’t have much handling prior to getting her and this product really helped take the edge off during stressful

Zylkene worked well for our flighty weanling. She didn’t have much handling prior to getting her and this product really helped take the edge off during stressful times. We were needing to give light sedatives before but this is doing the trick! It is palatable as she’s a picky eater too and it comes in handy packets that are easy on the go! I really wish it was show legal for my competition horses!!

Rated 4 out of 5 stars
By Review Report by Ruthie on Nov 8, 2025
Received Free Product

Not quite as effective as I had hoped

I used the product before and during horse shows. She didn't like the smell at first, but then decided it was O.K. The first day of the show there was a noticeable

I used the product before and during horse shows. She didn't like the smell at first, but then decided it was O.K. The first day of the show there was a noticeable difference in her behavior, but by the end of the second day it seemed as though it wasn't working quite as well. I do think the product works, but maybe not quite as well as I had hoped.

Rated 4 out of 5 stars
By Marvales2025 on Oct 29, 2025
Received Free Product

Give it a try!

First off, I have a picky eater, so being able to blend this in with his other grain and supplements is a plus! My horse gets anxious at turn in time, when other

First off, I have a picky eater, so being able to blend this in with his other grain and supplements is a plus! My horse gets anxious at turn in time, when other horses go in before him and he starts banging his gate. After using this product for a few days, he has quietly stood waiting for his turn. I would recommend giving it a try!

Rated 5 out of 5 stars
By Palomino Paint on Oct 1, 2025
Received Free Product

Terrific product for reducing anxiety

I received a full box of Zylkene as part of Chewy's Pawsabilities program, and, I must say, I was very pleasantly surprised. I used the Zylkene for one of the horses

I received a full box of Zylkene as part of Chewy's Pawsabilities program, and, I must say, I was very pleasantly surprised. I used the Zylkene for one of the horses in my barn that suffers from extreme anxiety when being worked on by the farrier. As directed, we gave the horse 2 packets of Zylkene once a day for 3 days prior to his farrier appointment. The Zylkene worked wonders and kept the horse calm -- without any effects of being sleepy/sedated. It's as if the anxiety disappeared!! Additionally, when mixed with his grain, the horse had zero problems eating it all right up - another plus!! We are going to try another 3-day dose in advance of his next trailering excursion, as he also gets quite anxious while loading. But for now, we'll be ordering more for use in advance of his farrier appointments because this product was a lifesaver!

Rated 5 out of 5 stars
By MalMom5 on Sep 30, 2025
Received Free Product

Very pleased

I was skeptical about this product because so many horse calming supplements are nothing more than smoke and empty promises. I must say that I was very pleasantly

I was skeptical about this product because so many horse calming supplements are nothing more than smoke and empty promises. I must say that I was very pleasantly surprised with zylkene. Not only was it palatable to my horse, it actually allowed him to be stress free and relaxed during a recent transition. He didn’t act sedated or hungover either. Highly recommend.

Rated 5 out of 5 stars
By Sableshepherds on Sep 19, 2025
Received Free Product

Simmered down lil Arab.

I am so impressed with this calming powder! I gave it to my horse once a day for three days leading up to a trail ride, and the difference was incredible. Normally,

I am so impressed with this calming powder! I gave it to my horse once a day for three days leading up to a trail ride, and the difference was incredible. Normally, he gets anxious and distracted in new surroundings, but this time he was relaxed, focused, and an absolute joy to ride. It didn’t make him dull or sluggish — just calm, confident, and easier to handle. I love that it’s simple to use and works exactly as promised. I’ll definitely keep this on hand for trail rides, shows, and any new situations. Highly recommend!

Rated 5 out of 5 stars
By Lacy on Sep 25, 2025
Received Free Product

Easy to use product with great results!

This product has worked exceptionally well on my 4 year old filly! My filly does not like to stand for the farrier and has some issues with anxiety when trailering

This product has worked exceptionally well on my 4 year old filly! My filly does not like to stand for the farrier and has some issues with anxiety when trailering. This product was a very simple to use powder; I just mix it in her grain and she eats with without hesitation. I can see a big difference in her behavior! My filly is much more calm and focused.. I was very pleased with this product and will continue to recommend this product!

Rated 2 out of 5 stars
By Karen on Sep 22, 2025
Received Free Product

I'm not convinced it helped at all.

I tried it on two horses with which I was going to attend a gathering. One accepted it fine. The other was suspicious but then ate it. I had mixed it with a supplemental

I tried it on two horses with which I was going to attend a gathering. One accepted it fine. The other was suspicious but then ate it. I had mixed it with a supplemental pellet. I gave it to them three days in a row. I did not notice any difference on the one that is now typically a nervous horse except it seemed she calmed a little sooner than I thought she would. The other one was no different either.

Rated 5 out of 5 stars
By Winnie approved on Oct 2, 2025
Received Free Product

Eats it just fine!

I was worried my horse would notice this in his food but the apple flavor is perfect for disguising anything and he eats it right up. I haven’t tried it for anything

I was worried my horse would notice this in his food but the apple flavor is perfect for disguising anything and he eats it right up. I haven’t tried it for anything specific yet, mostly just to see how he responds to it, he’s been wild anyways with the temperature changing.