Allopurinol (Generic) Tablets, slide 1 of 1

Allopurinol (Generic) Tablets

Prescription Item

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Strength: 300-mg
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Count: 1 tablet

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Allopurinol is a prescription medication tablet used for the prevention of kidney or bladder stones. It is also used to prevent increased uric acid levels in pets receiving cancer-related chemotherapy. Allopurinol works by reducing the amount of uric acid made by the body, which can cause gout and kidney problems. Customers may receive this drug under the name Zyloprim.


This medication is formulated for the management of pets with signs and symptoms of primary or secondary gout, pets with leukemia, lymphoma and malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels. It is also indicated for pets with recurrent calcium oxalate calculi, whose daily uric acid excretion exceeds 800 mg/day in males and 750 mg/day in female pets.

Possible Side Effects

The most frequent adverse reaction to allopurinol is skin rash. Skin reactions can be severe and sometimes fatal. Therefore, treatment with allopurinol should be discontinued immediately if a rash develops. Some pets with the most severe reaction also had a fever, chills, arthralgias, cholestatic jaundice, eosinophilia and mild leukocytosis or leukopenia.

Drug & Food Interactions

Talk to your veterinarian about any other medications, supplements or vitamins your pet is currently taking before starting allopurinol.


Before taking this medication, tell your veterinarian if your pet has liver or kidney disease or is pregnant or lactating. This medication should be used in adult dogs only. Do not use in puppies, kittens, or cats.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

NOTE: For Generic Medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer.

  1. Prescribing Information

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  • Item Number
  • Generic Name
  • Common Brand Name(s)
  • For Use With
  • Administration Form
  • Product Form
  • Health Condition
    Bladder Stones
  • Drug Type


Recommended Dosage

The dosage varies with the severity of the disease. The average is 200 to 300 mg per day for pets with mild gout and 400 to 600 mg per day for those with moderately severe tophaceous gout. The appropriate dosage may be administered in divided doses or as a single equivalent dose with the 300 mg tablet. Dosage requirements in excess of 300 mg should be administered in divided doses. The minimal effective dosage is 100 to 200 mg daily and the maximal recommended dosage is 800 mg daily. To reduce the possibility of flare-up of acute gout attacks, it is recommended that the pet start with a low dose of allopurinol (100 mg daily) and increase at weekly intervals by 100 mg until a serum uric acid level of 6 mg/dL or less is attained but without exceeding the maximal recommended dosage.

Storage Instructions

Store at temperatures from 68° - 77°F.


What is Allopurinol?

Allopurinol reduces the production of uric acid in the body. Allopurinol helps prevent the formation of bladder stones in dogs that are caused by high levels of uric acid.

What are the benefits of Allopurinol?

Prevents recurrent urate bladder stones. Ideal for canine breeds prone to blood flow abnormalities

How is this medication given?

Allopurinol is orally given.

How does this medication work?

Give this medication exactly as directed by your veterinarian. Allopurinol should be given with food to lessen stomach upset. Allopurinol should be given with lots of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you.

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