Amitriptyline HCl (Generic) Tablets, 25-mg, 1 tablet

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About This Item

Details

  • Treats behavior conditions, pruritus, postspaying urinary incontinence, chronic pain in dogs and anxiety, behavior conditions, and as adjunctive treatment of neuropathic pain in cats.
  • Works by blocking the reabsorptin of serotonin and norepinephrine. By increasing the amount of both of these, Amitriptyline helps the brain regulate mood and behavior.
  • Not given on an as needed basis, but continously and may require several weeks to see a positive response.
  • Contact your veterinarian before making any treatment changes. Serious side effects are rare.
  • Behavioral disorders may also require the use of additional medications, daily modifications to routine, environmental changes, supplements, or other medical therapies.

Ingredients

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FAQ

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4.5
Rated 4.5 out of 5 stars
178 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

88% Positive

Effectiveness

86% Positive

Ingredients

85% Positive

Long-Term Benefits

90% Positive

65 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 1 out of 5 stars
By LauraV on Dec 10, 2025
Top 1000 Contibutor

Doesn't help my dogs anxiety

My dog Winter has been taking this for a couple months. I thought at first it was helping but it really isn't. She is so skittish and I was so hopeful this would

My dog Winter has been taking this for a couple months. I thought at first it was helping but it really isn't. She is so skittish and I was so hopeful this would help. She's terrified of everyone and basically anything that moves. You move a box to quickly and she jumps out of her skin. I tried fluoxetine first and that did nothing. Next my vet wants her to try clomipramine. Hopefully that does something!

Rated 5 out of 5 stars
By Bernadette on Dec 2, 2025

Color and size

Easy size to give and good color to see when he would spit it out. Unfortunately, this medication didn’t work for my cat, he’s still aggressive towards my other

Easy size to give and good color to see when he would spit it out. Unfortunately, this medication didn’t work for my cat, he’s still aggressive towards my other cat. I’m sure it’s worked for others. Good luck

Rated 2 out of 5 stars
By Pippen on Sep 20, 2025

Inconsistent quality

These are generic and come from various manufacturers. One manufacturer sends a pill that is ineffective and our cat starts right back into his inappropriate urinating

These are generic and come from various manufacturers. One manufacturer sends a pill that is ineffective and our cat starts right back into his inappropriate urinating within a few days. The other manufacturer seems legit and the results are consistent. And there’s no way to specify which you want so it’s luck of the draw and the times we get the bad ones we are in for a month of cleaning up urine everywhere and starting back from scratch when the next month’s supply comes. (And hoping it’s not from the same manufacturer)

Rated 1 out of 5 stars
By Cat on Oct 29, 2025

Major GI upset and Zero Behavior Change

Both dogs started having explosive diarrhea, my older dog even started vomiting and became lethargic. On top of the GI upset, the younger dog still wants to eat

Both dogs started having explosive diarrhea, my older dog even started vomiting and became lethargic. On top of the GI upset, the younger dog still wants to eat the stool and now even the vomit. Requesting refund from company, completely unsatisfied.

Rated 5 out of 5 stars
By Cathy on Sep 12, 2025

Great price

These small coated pills must be cut in half for my little cat Cherise. The coating ensures that they don't break up or cut unevenly in the pill cutter. Chewy always

These small coated pills must be cut in half for my little cat Cherise. The coating ensures that they don't break up or cut unevenly in the pill cutter. Chewy always contacts my vet right away for refills on this med, and I always get the Rx in plenty of time. Will keep buying from Chewy, it is so easy and reliable.

Rated 5 out of 5 stars
By Debora on Dec 3, 2025

Home delivery

Lovely to be able to have the meds delivered to me now that two of my cats are on meds. Thank you, Chewy!

Lovely to be able to have the meds delivered to me now that two of my cats are on meds. Thank you, Chewy!

Rated 1 out of 5 stars
By Susan on Feb 1, 2026

Yes and no

It works for crumpet but not die Colby or mango. Sheesh.

It works for crumpet but not die Colby or mango. Sheesh.

Rated 5 out of 5 stars
By MICHAEL on Oct 7, 2025

Quick & Easy

Having Chewy deliver our pets meds saved us so much time and energy. It’s taken so much stress out of having to schedule a day around just getting to the vets. Thanks

Having Chewy deliver our pets meds saved us so much time and energy. It’s taken so much stress out of having to schedule a day around just getting to the vets. Thanks Chewy.com!

Rated 2 out of 5 stars
By Alexandra on Jun 27, 2025

Coating comes off too easily

For a long time Chewy used the manufacturer Unichem for its amitriptyline and everything was fine. Now they use Advagen and the pills SUCK. They are orange and the

For a long time Chewy used the manufacturer Unichem for its amitriptyline and everything was fine. Now they use Advagen and the pills SUCK. They are orange and the coating comes off very easily. I usually hide the pill in my cats’ food and they have no problem eating it. Now they won’t eat these pills by Advagen because the coating comes off so easy, leaving a bitter taste. Chewy, please go back to Unichem!

Rated 5 out of 5 stars
By Amber on Sep 15, 2025

Auto shipping

The auto shipping option is convenient, one less thing I have to remember. Knowing my pup never runs out of her medicine.

The auto shipping option is convenient, one less thing I have to remember. Knowing my pup never runs out of her medicine.