10 Best Heart & Liver Supplements for Cats 2025: According to Reviews | Chewy

The 10 Best Heart & Liver Supplements for Cats

Jump to the list

How we created this heart & liver supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best heart & liver supplements for cat.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best heart & liver supplements for cats.

Key heart & liver supplement considerations

Dosage

Effectiveness

Form

Ingredients

1
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle

Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle

Rated 4.6 out of 5 stars
1,213
$32.99Chewy Price
($1.10/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.5/5
Great

Form

4.4/5
Great

Ingredients

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: S-Adenosylmethionine, Silybin A+B

Health Feature

Liver Care
2
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rated 4.6 out of 5 stars
255
$43.94Chewy Price
($0.25/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.5/5
Great

Form

4.4/5
Great

Ingredients

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ingredients per capsule: Milk Thistle Extract 100 mg (EMed-MT premium providing 80% Silymarin and 30% silybinin) Inositol 20 mg Choline 20 mg DL-Methionine(pharmaceutical grade) 20 mg Pantothenic Acid (calcium pantothenate) 10 mg Vitamin B-1 (thiamine) 5 mg Vitamin B-2 (riboflavin) 5 mg Vitamin B-6 (pyridoxine) 5 mg Alpha Lipoic Acid 5 mg Vitamin B-12 (cyanocobalamin) 10 mcg Inactive ingredients: Gelatin‚ glycerin‚ silica and water

Food Flavor

Unflavored
3
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle

Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 4-oz bottle

Rated 4.5 out of 5 stars
217
$64.95Chewy Price
($16.24/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Form

4.4/5
Great

Ingredients

4.5/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Organic Milk Thistle Seed (Silybum Marianum)., Inactive Ingredients: Deionized Water, Natural Bacon Flavor (Glycerin-Based), Vegetable Glycerin

Food Flavor

Bacon, Liver, Meat
4
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Rated 4.6 out of 5 stars
194
$14.99Chewy Price
($0.20/g)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.2/5
Great

Form

4.3/5
Great

Ingredients

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ground Milk Thistle (Supports Healthy Liver Function)

Food Flavor

Unflavored
5
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules

Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules

Rated 4.6 out of 5 stars
88
$44.61Chewy Price
($0.38/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Form

4.5/5
Great

Ingredients

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active: L-Carnitine Tartrate 300mg, Taurine 250mg, Coenzyme Q10 50mg, Organic Hawthorn Berry 50mg, Vitamin E (D Alpha Tocopherol) 10IU

Special Diet

Non-GMO, Soy Free, Grain-Free, Gluten Free
6
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count
VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count

VetriScience Cardio Strength Capsules Heart Supplement for Cats & Dogs, 90 count

Rated 4.2 out of 5 stars
243
$30.49Chewy Price
($0.34/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Form

4.0/5
Great

Ingredients

4.1/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: L-Carnitine HCl, L-Taurine, N, N-Dimethylglycine HCl, D-Alpha Tocopheryl Succinate (Vitamin E)

Health Feature

Heart Care
7
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count

VetClassics Liver Support Soft Chews Dog & Cat Supplement, 60 count

Rated 4.1 out of 5 stars
95
$37.99Chewy Price
($0.64/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

3.6/5
Good

Effectiveness

4.5/5
Great

Form

4.2/5
Great

Ingredients

4.0/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients Per 3 g Soft Chew: Milk Thistle 200 mg, Dandelion Root 75 mg, Vitamin C (Calcium Ascorbate) 50 mg, Thiamine (Vitamin B1) 30 mg, Glutathione 20 mg

Food Flavor

Unflavored
8
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count

Nutramax Denosyl Tablets Liver & Brain Supplement for Small Dogs & Cats, 30 count

Rated 4.7 out of 5 stars
137
$23.99Chewy Price
($0.80/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.2/5
Great

Form

4.2/5
Great

Ingredients

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

Extra Small Breeds, Small Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

S-Adenosylmethionine

Health Feature

Liver Care
9
Prana Pets Liver Function Support Liquid Cat & Dog Supplement, 2-fl oz bottle
Prana Pets Liver Function Support Liquid Cat & Dog Supplement, 2-fl oz bottle
Prana Pets Liver Function Support Liquid Cat & Dog Supplement, 2-fl oz bottle
Prana Pets Liver Function Support Liquid Cat & Dog Supplement, 2-fl oz bottle
Prana Pets Liver Function Support Liquid Cat & Dog Supplement, 2-fl oz bottle
Prana Pets Liver Function Support Liquid Cat & Dog Supplement, 2-fl oz bottle
Prana Pets Liver Function Support Liquid Cat & Dog Supplement, 2-fl oz bottle

Prana Pets Liver Function Support Liquid Cat & Dog Supplement, 2-fl oz bottle

Rated 4.4 out of 5 stars
27
$37.95Chewy Price
($18.98/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.5/5
Great

Form

4.6/5
Excellent

Ingredients

4.6/5
Excellent

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active: Boldo 4X, Carduus Marianus 4X, Chelidonium Majus 4X, Cynara Scolymus 4X, Kali Muriaticum 12X

Special Diet

Plant Based, Natural
10
Animal Essentials Liver Defense Support Dog & Cat Supplement, 2-fl oz bottle
Animal Essentials Liver Defense Support Dog & Cat Supplement, 2-fl oz bottle
Animal Essentials Liver Defense Support Dog & Cat Supplement, 2-fl oz bottle
Animal Essentials Liver Defense Support Dog & Cat Supplement, 2-fl oz bottle

Animal Essentials Liver Defense Support Dog & Cat Supplement, 2-fl oz bottle

Rated 4.1 out of 5 stars
73
$30.99Chewy Price
($15.50/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.7/5
Excellent

Form

4.6/5
Excellent

Ingredients

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: A Proprietary Blend Containing Extracts of Certified Organic Milk Thistle Seed 1:4, Dandelion Root and Leaf 1:4., Inactive Ingredients: Vegetable Glycerin USP, Distilled Water, Grain Alcohol USP 20% By Volume

Special Diet

Plant Based