10 Best Heart & Liver Supplements for Dogs 2025: According to Reviews | Chewy

The 10 Best Heart & Liver Supplements for Dogs

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How we created this heart & liver supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best heart & liver supplements for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best heart & liver supplements for dogs.

Key heart & liver supplement considerations

Dosage

Effectiveness

Ingredients

Safety

1
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Rated 4.6 out of 5 stars
1,756
$74.99Chewy Price
($2.50/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.2/5
Great

Safety

4.2/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: S-Adenosylmethionine, Silybin A+B

Packaging Type

Bottle
2
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rated 4.6 out of 5 stars
327
$46.99Chewy Price
($0.27/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.2/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ingredients per capsule: Milk Thistle Extract 100 mg (EMed-MT premium providing 80% Silymarin and 30% silybinin) Inositol 20 mg Choline 20 mg DL-Methionine(pharmaceutical grade) 20 mg Pantothenic Acid (calcium pantothenate) 10 mg Vitamin B-1 (thiamine) 5 mg Vitamin B-2 (riboflavin) 5 mg Vitamin B-6 (pyridoxine) 5 mg Alpha Lipoic Acid 5 mg Vitamin B-12 (cyanocobalamin) 10 mcg Inactive ingredients: Gelatin‚ glycerin‚ silica and water

Food Flavor

Unflavored
3
Wanderfound Pets SAMe 100 Liver Support for Dogs, 60 count
Wanderfound Pets SAMe 100 Liver Support for Dogs, 60 count
Wanderfound Pets SAMe 100 Liver Support for Dogs, 60 count
Wanderfound Pets SAMe 100 Liver Support for Dogs, 60 count
Wanderfound Pets SAMe 100 Liver Support for Dogs, 60 count
Wanderfound Pets SAMe 100 Liver Support for Dogs, 60 count

Wanderfound Pets SAMe 100 Liver Support for Dogs, 60 count

Rated 4.5 out of 5 stars
174
$32.99Chewy Price
($0.55/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.6/5
Excellent

Effectiveness

4.7/5
Excellent

Ingredients

4.6/5
Excellent

Safety

4.5/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active: S-Adenosyl-L-Methionine p-tolunsulfate (SAM-e PATES) 100 mg, Inactive: Dicalcium Phosphate, Liver, Microcystalline Cellulose & Silicone Dioxide, Natural/Artificial Bacon Flavor

Food Flavor

Bacon, Meat
4
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle

Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle

Rated 4.4 out of 5 stars
280
$19.95Chewy Price
($9.98/fl oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.6/5
Excellent

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Omega-3 Fatty Acids (from Salmon Oil) with 75 mg EPA and 85 mg DHA: 250 mg, Milk Thistle Extract (Sylibum marianum) (Seed): 50 mg, Curcumin C3 Complex Turmeric Root Extract (95% Curcuminoids) (Curcuma longa): 27 mg

Special Diet

Human-Grade, Natural
5
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle

Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle

Rated 4.5 out of 5 stars
248
$64.95Chewy Price
($16.24/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Safety

4.2/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Organic Milk Thistle Seed (Silybum Marianum)., Inactive Ingredients: Deionized Water, Natural Bacon Flavor (Glycerin-Based), Vegetable Glycerin

Food Flavor

Bacon, Liver, Meat
6
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count

Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count

Rated 4.7 out of 5 stars
136
$54.99Chewy Price
($1.84/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Safety

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

Medium Breeds, Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Actual Ingredients: S-Adenosylmethionine

Packaging Type

Box
7
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Rated 4.6 out of 5 stars
212
$25.99Chewy Price
($0.35/g)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.4/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ground Milk Thistle (Supports Healthy Liver Function)

Food Flavor

Unflavored
8
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count

Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count

Rated 4.3 out of 5 stars
359
$36.97Chewy Price
($0.42/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

3.9/5
Good

Effectiveness

4.3/5
Great

Ingredients

4.2/5
Great

Safety

4.1/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Milk Thistle Extract (Min. 80% Silymarin) (Silactive™), Turmeric Extract, Choline Bitartrate, N-Acetyl Cysteine (NAC), Dandelion Root

Food Flavor

Chicken, Poultry
9
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules

Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules

Rated 4.5 out of 5 stars
119
$44.95Chewy Price
($0.38/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active: L-Carnitine Tartrate 300mg, Taurine 250mg, Coenzyme Q10 50mg, Organic Hawthorn Berry 50mg, Vitamin E (D Alpha Tocopherol) 10IU

Special Diet

Non-GMO, Soy Free, Grain-Free, Gluten Free
10
VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count
VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count
VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count
VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count

VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count

Rated 4.5 out of 5 stars
113
$13.49Chewy Price
($0.14/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.3/5
Great

Safety

4.5/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Coenzyme Q10., Inactive Ingredients: Cellulose, Gelatin, Maltodextrin, Silicon Dioxide

Food Flavor

Unflavored