10 Best Heart & Liver Supplements for Dogs 2026: According to Reviews | Chewy

The 10 Best Heart & Liver Supplements for Dogs

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How we created this heart & liver supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best heart & liver supplements for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best heart & liver supplements for dogs.

Key heart & liver supplement considerations

Dosage

Effectiveness

Ingredients

Safety

1
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Rated 4.6 out of 5 stars
1,858
$74.99Chewy Price
($2.50/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.1/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.2/5
Great

Safety

4.2/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: S-Adenosylmethionine, Silybin A+B

Packaging Type

Bottle
2
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rated 4.6 out of 5 stars
340
$46.99Chewy Price
($0.27/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ingredients per capsule: Milk Thistle Extract 100 mg (EMed-MT premium providing 80% Silymarin and 30% silybinin) Inositol 20 mg Choline 20 mg DL-Methionine(pharmaceutical grade) 20 mg Pantothenic Acid (calcium pantothenate) 10 mg Vitamin B-1 (thiamine) 5 mg Vitamin B-2 (riboflavin) 5 mg Vitamin B-6 (pyridoxine) 5 mg Alpha Lipoic Acid 5 mg Vitamin B-12 (cyanocobalamin) 10 mcg Inactive ingredients: Gelatin‚ glycerin‚ silica and water

Food Flavor

Unflavored
3
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count

Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count

Rated 4.5 out of 5 stars
332
$19.98Chewy Price
($0.20/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.5/5
Great

Safety

4.2/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Milk Thistle Seed Extract (Silybum Marianum) 100 mg, Artichoke Leaf Extract (Cyrana Scolymus) 25 mg, Dandelion Root Extract (Taraxacum Officinale) 25 mg, Yellow Dock (Root) (Rumex Crispus) 25 mg, Inactive: Microcrystalline Cellulose & Silicon Dioxide

Food Flavor

Salmon, Bacon, Meat, Seafood & Fish
4
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle

Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle

Rated 4.5 out of 5 stars
256
$64.95Chewy Price
($16.24/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.4/5
Great

Safety

4.1/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Organic Milk Thistle Seed (Silybum Marianum)., Inactive Ingredients: Deionized Water, Natural Bacon Flavor (Glycerin-Based), Vegetable Glycerin

Food Flavor

Bacon, Liver, Meat
5
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count

Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count

Rated 4.7 out of 5 stars
140
$44.99Chewy Price
($1.50/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

Medium Breeds, Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Actual Ingredients: S-Adenosylmethionine

Packaging Type

Box
6
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count

Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count

Rated 4.3 out of 5 stars
371
$36.97Chewy Price
($0.42/ea)
Promo, Save 50% on your first Autoship

Our ratings

Dosage

3.9/5
Good

Effectiveness

4.3/5
Great

Ingredients

4.1/5
Great

Safety

4.0/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Milk Thistle Extract (Min. 80% Silymarin) (Silactive™), Turmeric Extract, Choline Bitartrate, N-Acetyl Cysteine (NAC), Dandelion Root

Food Flavor

Chicken, Poultry
7
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Rated 4.6 out of 5 stars
221
$25.99Chewy Price
($0.35/g)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.4/5
Great

Safety

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ground Milk Thistle (Supports Healthy Liver Function)

Food Flavor

Unflavored
8
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules

Fera Pets Cardiac Support Salmon Flavor Supplement for Dog & Cat, 120 capsules

Rated 4.5 out of 5 stars
128
$44.95Chewy Price
($0.38/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.4/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active: L-Carnitine Tartrate 300mg, Taurine 250mg, Coenzyme Q10 50mg, Organic Hawthorn Berry 50mg, Vitamin E (D Alpha Tocopherol) 10IU

Special Diet

Non-GMO, Soy Free, Grain-Free, Gluten Free
9
VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count
VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count
VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count
VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count

VetriScience Coenzyme Q10 10 mg Capsules Heart Supplement for Cats & Dogs, 100 count

Rated 4.6 out of 5 stars
116
$13.49Chewy Price
($0.14/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.5/5
Great

Effectiveness

4.6/5
Excellent

Ingredients

4.3/5
Great

Safety

4.5/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Coenzyme Q10., Inactive Ingredients: Cellulose, Gelatin, Maltodextrin, Silicon Dioxide

Food Flavor

Unflavored
10
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count
CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count

CardioMAX Heart Support Supplement Soft Chews for Dogs, 60 count

Rated 4.7 out of 5 stars
67
$25.99Chewy Price
($0.44/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.3/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: L-Taurine, Arginine, Hawthorne, Elcosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA)

Food Flavor

Fruits & Vegetables