10 Best Heart & Liver Supplements for Dogs 2025: According to Reviews | Chewy

The 10 Best Heart & Liver Supplements for Dogs

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How we created this heart & liver supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best heart & liver supplements for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best heart & liver supplements for dogs.

Key heart & liver supplement considerations

Dosage

Effectiveness

Ingredients

Safety

1
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Rated 4.6 out of 5 stars
1,270
$75.99Chewy Price
($2.54/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: S-Adenosylmethionine, Silybin A+B

Health Feature

Liver Care
2
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rated 4.6 out of 5 stars
232
$43.94Chewy Price
($0.25/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Safety

4.5/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ingredients per capsule: Milk Thistle Extract 100 mg (EMed-MT premium providing 80% Silymarin and 30% silybinin) Inositol 20 mg Choline 20 mg DL-Methionine(pharmaceutical grade) 20 mg Pantothenic Acid (calcium pantothenate) 10 mg Vitamin B-1 (thiamine) 5 mg Vitamin B-2 (riboflavin) 5 mg Vitamin B-6 (pyridoxine) 5 mg Alpha Lipoic Acid 5 mg Vitamin B-12 (cyanocobalamin) 10 mcg Inactive ingredients: Gelatin‚ glycerin‚ silica and water

Food Flavor

Unflavored
3
Wonder Paws Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle

Wonder Paws Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle

Rated 4.4 out of 5 stars
210
$19.95Chewy Price
($9.98/fl oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.7/5
Excellent

Safety

4.5/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Omega-3 Fatty Acids (from Salmon Oil) with 75 mg EPA and 85 mg DHA: 250 mg, Milk Thistle Extract (Sylibum marianum) (Seed): 50 mg, Curcumin C3 Complex Turmeric Root Extract (95% Curcuminoids) (Curcuma longa): 27 mg

Special Diet

Human-Grade, Natural
4
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle

Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs & Cats, 2-oz bottle

Rated 4.5 out of 5 stars
207
$40.95Chewy Price
($20.48/oz)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.5/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Organic Milk Thistle Seed (Silybum Marianum)., Inactive Ingredients: Deionized Water, Natural Bacon Flavor (Glycerin-Based), Vegetable Glycerin

Food Flavor

Bacon, Liver, Meat
5
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count

Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count

Rated 4.4 out of 5 stars
222
$19.98Chewy Price
($0.20/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Ingredients

4.7/5
Excellent

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Milk Thistle Seed Extract (Silybum Marianum) 100 mg, Artichoke Leaf Extract (Cyrana Scolymus) 25 mg, Dandelion Root Extract (Taraxacum Officinale) 25 mg, Yellow Dock (Root) (Rumex Crispus) 25 mg, Inactive: Microcrystalline Cellulose & Silicon Dioxide

Food Flavor

Salmon, Bacon, Meat, Seafood & Fish
6
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count
Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count

Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count

Rated 4.7 out of 5 stars
101
$54.99Chewy Price
($1.84/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.4/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

Medium Breeds, Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Actual Ingredients: S-Adenosylmethionine

Health Feature

Liver Care
7
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count
Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count

Zesty Paws Cardio Bites Salmon Flavored Soft Chews Heart Supplement for Dogs, 90 count

Rated 4.7 out of 5 stars
133
$36.97Chewy Price
($0.42/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.7/5
Excellent

Effectiveness

4.5/5
Great

Ingredients

4.3/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: L-Carnitine, Taurine, Hawthorn Berry, L-Arginine, Fish Oil (AlaskOmega®)

Food Flavor

Salmon, Seafood & Fish
8
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Rated 4.6 out of 5 stars
181
$14.99Chewy Price
($0.20/g)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.1/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ground Milk Thistle (Supports Healthy Liver Function)

Food Flavor

Unflavored
9
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules
Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules

Fera Pets Cardiac Support Salmon Flavor Dog & Cat Supplement, 120 capsules

Rated 4.6 out of 5 stars
78
$42.95Chewy Price
($0.36/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.3/5
Great

Safety

4.4/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active: L-Carnitine Tartrate 300mg, Taurine 250mg, Coenzyme Q10 50mg, Organic Hawthorn Berry 50mg, Vitamin E (D Alpha Tocopherol) 10IU

Special Diet

Non-GMO, Soy Free, Grain-Free, Gluten Free
10
CardioMAX Soft Chew Dog Heart Supplement, 60 count
CardioMAX Soft Chew Dog Heart Supplement, 60 count
CardioMAX Soft Chew Dog Heart Supplement, 60 count
CardioMAX Soft Chew Dog Heart Supplement, 60 count
CardioMAX Soft Chew Dog Heart Supplement, 60 count
CardioMAX Soft Chew Dog Heart Supplement, 60 count
CardioMAX Soft Chew Dog Heart Supplement, 60 count
CardioMAX Soft Chew Dog Heart Supplement, 60 count

CardioMAX Soft Chew Dog Heart Supplement, 60 count

Rated 4.7 out of 5 stars
40
$24.99Chewy Price
($0.42/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage

4.7/5
Excellent

Effectiveness

4.5/5
Great

Ingredients

4.5/5
Great

Safety

4.5/5
Great

Is this heart & liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: L-Taurine, Arginine, Hawthorne, Elcosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA)

Food Flavor

Fruits & Vegetables