10 Best Immune System & Allergy Supplements for Dogs 2025: According to Reviews | Chewy

The 10 Best Immune System & Allergy Supplements for Dogs

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How we created this immune system & allergy supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best immune system & allergy supplements for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best immune system & allergy supplements for dogs.

Key immune system & allergy supplement considerations

Dosage and Administration

Effectiveness

Ingredients

Safety

1
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count

Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count

Rated 4.9 out of 5 stars
136
$21.99Chewy Price
($0.37/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.8/5
Excellent

Effectiveness

4.9/5
Excellent

Ingredients

4.8/5
Excellent

Safety

4.8/5
Excellent

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Pumpkin Powder, Chicory Root, Yea-Sacc OA, Tynagen, 7-strain Immunity Blend

Special Diet

Natural, No Corn No Wheat No Soy, Low Fat, Limited Ingredient Diet...
2
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count

Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count

Rated 4.2 out of 5 stars
567
$25.99Chewy Price
($0.29/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.2/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.3/5
Great

Safety

4.2/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Colostrum, Apple Cider Vinegar, Salmon Oil, Astragalus Root, Wellmune® Baker’s Yeast Beta 1

Food Flavor

Peanut Butter
3
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count

Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count

Rated 4.5 out of 5 stars
4,358
$32.97Chewy Price
($0.37/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

3.9/5
Good

Effectiveness

4.0/5
Great

Ingredients

4.0/5
Great

Safety

4.0/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Colostrum (Bovine), Dried Fermentate (Made Using Saccharomyces cerevisiae) (EpiCor® Pets), Astragalus Root, 6-Strain Gut Health Blend (Bacillus subtilis, Lactobacillus acidophilus

Food Flavor

Lamb, Meat
4
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count

Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count

Rated 4.2 out of 5 stars
1,155
$34.00Chewy Price
($0.38/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.3/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Safety

4.4/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Colostrum (Bovine): 150mg, Wild Alaskan Salmon Oil: 100mg, Fructooligosaccharides (FOS): 100 mg, Quercetin: 50mg, Bee Propolis: 10mg

Special Diet

Grain-Free, No Corn No Wheat No Soy, Chicken-Free, Natural
5
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count

StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count

Rated 4.5 out of 5 stars
188
$23.80Chewy Price
($0.20/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.6/5
Excellent

Effectiveness

4.5/5
Great

Ingredients

4.6/5
Excellent

Safety

4.4/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Brewers Dried Yeast, Dried Potato Product, Glycerin, Flaxseed, Lecithin

Special Diet

Rawhide-Free, No Corn No Wheat No Soy
6
Native Pet Allergy & Immune Chews Allergy & Itch Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy & Itch Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy & Itch Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy & Itch Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy & Itch Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy & Itch Relief Supplement for Dogs, 60 count

Native Pet Allergy & Immune Chews Allergy & Itch Relief Supplement for Dogs, 60 count

Rated 4.2 out of 5 stars
472
$24.99Chewy Price
($0.42/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.1/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.3/5
Great

Safety

4.1/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Top Ingredients

Active Ingredients: Colustrum, Spirulina, Colostrum, Dried Yeast Fermentate, Algae Oil

Special Diet

Gluten Free, Natural, Limited Ingredient Diet, Grain-Free

Food Flavor

Chicken
7
NaturVet Mushroom Max with Turkey Tail Soft Chews Immune Supplement for Cats & Dogs, 120 count
NaturVet Mushroom Max with Turkey Tail Soft Chews Immune Supplement for Cats & Dogs, 120 count
NaturVet Mushroom Max with Turkey Tail Soft Chews Immune Supplement for Cats & Dogs, 120 count
NaturVet Mushroom Max with Turkey Tail Soft Chews Immune Supplement for Cats & Dogs, 120 count

NaturVet Mushroom Max with Turkey Tail Soft Chews Immune Supplement for Cats & Dogs, 120 count

Rated 4.5 out of 5 stars
194
$42.97Chewy Price
($0.36/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.3/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.2/5
Great

Safety

4.3/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Reishi Mushroom, Shiitake Mushroom, Turkey Tail Mushroom, Maitake Mushroom, N-acetyl-L-cysteine

Food Flavor

Turkey, Poultry
8
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count
Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count

Pet Parents Allergy SoftSupps Immune & Allergy Relief Dog Supplement, 90 count

Rated 4.4 out of 5 stars
120
$29.99Chewy Price
($0.34/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Ingredients

4.5/5
Great

Safety

4.6/5
Excellent

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Colostrum (250mg), Biomos(200mg), Apple Cider Vinegar (80mg), Salmon Oil (80mg), Organic Licorice Root (50mg)

Special Diet

No Corn No Wheat No Soy, Grain-Free, Chicken-Free, Soy Free
9
Fera Pets Mushroom Immune Support Dog & Cat Supplement, 120 servings
Fera Pets Mushroom Immune Support Dog & Cat Supplement, 120 servings
Fera Pets Mushroom Immune Support Dog & Cat Supplement, 120 servings
Fera Pets Mushroom Immune Support Dog & Cat Supplement, 120 servings
Fera Pets Mushroom Immune Support Dog & Cat Supplement, 120 servings
Fera Pets Mushroom Immune Support Dog & Cat Supplement, 120 servings
Fera Pets Mushroom Immune Support Dog & Cat Supplement, 120 servings

Fera Pets Mushroom Immune Support Dog & Cat Supplement, 120 servings

Rated 4.5 out of 5 stars
190
$34.95Chewy Price
($0.30/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

4.5/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Safety

4.4/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Proprietary Mushroom Blend: Organic Lion's Mane, Organic Red Reishi, Organic Shiitake, Organic Cordyceps, Organic Maitake

Special Diet

Gluten Free, Grain-Free, No Corn No Wheat No Soy, Pea-Free...
10
Bark&Spark Allergy Relief & Anti Itch Relief with Omega 3 Skin & Coat Fish Oil Chew Supplement for Dogs, 120 count
Bark&Spark Allergy Relief & Anti Itch Relief with Omega 3 Skin & Coat Fish Oil Chew Supplement for Dogs, 120 count
Bark&Spark Allergy Relief & Anti Itch Relief with Omega 3 Skin & Coat Fish Oil Chew Supplement for Dogs, 120 count
Bark&Spark Allergy Relief & Anti Itch Relief with Omega 3 Skin & Coat Fish Oil Chew Supplement for Dogs, 120 count
Bark&Spark Allergy Relief & Anti Itch Relief with Omega 3 Skin & Coat Fish Oil Chew Supplement for Dogs, 120 count
Bark&Spark Allergy Relief & Anti Itch Relief with Omega 3 Skin & Coat Fish Oil Chew Supplement for Dogs, 120 count

Bark&Spark Allergy Relief & Anti Itch Relief with Omega 3 Skin & Coat Fish Oil Chew Supplement for Dogs, 120 count

Rated 4 out of 5 stars
593
$23.99Chewy Price
($0.20/ea)
Promo, Spend $100, Get $30 eGift Card with code HAVEFUN

Our ratings

Dosage and Administration

3.8/5
Good

Effectiveness

4.0/5
Great

Ingredients

3.9/5
Good

Safety

3.9/5
Good

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active: Omega-3 Fatty Acids (Fish Oil), Turmeric Root, Grape Seed Extract, Quercetin, Pumpkin Powder

Special Diet

Human-Grade, No Corn No Wheat No Soy, Rawhide-Free, Sugar Free...