10 Best Immune System & Allergy Supplements for Dogs 2025: According to Reviews | Chewy

The 10 Best Immune System & Allergy Supplements for Dogs

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How we created this immune system & allergy supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best immune system & allergy supplements for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best immune system & allergy supplements for dogs.

Key immune system & allergy supplement considerations

Dosage and Administration

Effectiveness

Ingredients

Safety

1
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz bag
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz bag
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz bag
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz bag
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz bag
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz bag
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz bag

Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz bag

Rated 4.8 out of 5 stars
257
$29.99Chewy Price
($13.64/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.8/5
Excellent

Effectiveness

4.8/5
Excellent

Ingredients

4.8/5
Excellent

Safety

4.8/5
Excellent

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages

Special Diet

Gluten Free, No Corn No Wheat No Soy

Packaging Type

Can
2
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count

Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count

Rated 4.8 out of 5 stars
140
$21.99Chewy Price
($0.37/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.8/5
Excellent

Effectiveness

4.9/5
Excellent

Ingredients

4.8/5
Excellent

Safety

4.8/5
Excellent

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Pumpkin Powder, Chicory Root, Yea-Sacc OA, Tynagen, 7-strain Immunity Blend

Special Diet

Natural, No Corn No Wheat No Soy, Low Fat, Limited Ingredient Diet...
3
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count

Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count

Rated 4.4 out of 5 stars
4,824
$32.99Chewy Price
($0.37/ea)
Promo, Save 50% on your first Autoship

Our ratings

Dosage and Administration

3.8/5
Good

Effectiveness

3.9/5
Good

Ingredients

3.9/5
Good

Safety

3.8/5
Good

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Colostrum (Bovine), Dried Fermentate (Made Using Saccharomyces cerevisiae) (EpiCor® Pets), Astragalus Root, 6-Strain Gut Health Blend (Bacillus subtilis, Lactobacillus acidophilus

Food Flavor

Lamb, Meat
4
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 14 count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 14 count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 14 count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 14 count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 14 count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 14 count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 14 count

Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 14 count

Rated 4.1 out of 5 stars
757
$3.99Chewy Price
($0.29/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.2/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.3/5
Great

Safety

4.1/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Colostrum, Apple Cider Vinegar, Salmon Oil, Astragalus Root, Wellmune® Baker’s Yeast Beta 1

Food Flavor

Peanut Butter
5
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count
Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count

Finn Allergy & Itch Beef Liver Flavored Soft Chew Allergy Supplement for Dogs, 90 count

Rated 4.1 out of 5 stars
1,286
$34.99Chewy Price
($0.39/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Safety

4.2/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Colostrum (Bovine): 150mg, Wild Alaskan Salmon Oil: 100mg, Fructooligosaccharides (FOS): 100 mg, Quercetin: 50mg, Bee Propolis: 10mg

Special Diet

Grain-Free, No Corn No Wheat No Soy, Chicken-Free, Natural
6
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count

StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count

Rated 4.5 out of 5 stars
217
$23.99Chewy Price
($0.20/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.6/5
Excellent

Effectiveness

4.4/5
Great

Ingredients

4.5/5
Great

Safety

4.2/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Brewers Dried Yeast, Dried Potato Product, Glycerin, Flaxseed, Lecithin

Special Diet

Rawhide-Free, No Corn No Wheat No Soy
7
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL

VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL

Rated 4.6 out of 5 stars
230
$27.99Chewy Price
($0.25/mL)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.7/5
Excellent

Effectiveness

4.7/5
Excellent

Ingredients

4.7/5
Excellent

Safety

4.5/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Each Drop Contains: 6 mg, of N-Dimethylglycine (D mg )., Inactive Ingredients: Citric Acid, Glycerin, Malic Acid

Special Diet

Human-Grade
8
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count

NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count

Rated 4.5 out of 5 stars
255
$43.99Chewy Price
($0.37/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.1/5
Great

Safety

4.2/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Reishi Mushroom, Shiitake Mushroom, Turkey Tail Mushroom, Maitake Mushroom, N-acetyl-L-cysteine

Food Flavor

Turkey, Poultry
9
VetClassics CAS Options Extra Strength Immune & Antioxidant Support Dog & Cat Supplement, 120 count
VetClassics CAS Options Extra Strength Immune & Antioxidant Support Dog & Cat Supplement, 120 count
VetClassics CAS Options Extra Strength Immune & Antioxidant Support Dog & Cat Supplement, 120 count
VetClassics CAS Options Extra Strength Immune & Antioxidant Support Dog & Cat Supplement, 120 count
VetClassics CAS Options Extra Strength Immune & Antioxidant Support Dog & Cat Supplement, 120 count
VetClassics CAS Options Extra Strength Immune & Antioxidant Support Dog & Cat Supplement, 120 count

VetClassics CAS Options Extra Strength Immune & Antioxidant Support Dog & Cat Supplement, 120 count

Rated 4.9 out of 5 stars
45
$62.09Chewy Price
($0.52/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.3/5
Great

Effectiveness

4.6/5
Excellent

Ingredients

4.7/5
Excellent

Safety

4.6/5
Excellent

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients per 4 g Soft Chew: Reishi Mushroom 578 mg, Shiitake Mushroom 446 mg, Turkey Tail Mushroom 150 mg, Maitake Mushroom 95 mg, N-acetyl-L-cysteine 79 mg

Food Flavor

Unflavored
10
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar
Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar

Fera Pets Mushroom Cognitive & Immune Support Powder Supplement for Dog & Cat, 2.12-oz jar

Rated 4.5 out of 5 stars
247
$34.99Chewy Price
($16.51/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Proprietary Mushroom Blend: Organic Lion's Mane, Organic Red Reishi, Organic Shiitake, Organic Cordyceps, Organic Maitake

Special Diet

Gluten Free, Grain-Free, No Corn No Wheat No Soy, Pea-Free...