Best Liver Supplements for Dogs 2026: According to Reviews | Chewy

Best Liver Supplements For Dogs

How we created this liver supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best liver supplements for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best liver supplements for dogs.

Key liver supplement considerations

Effectiveness in Supporting Liver Health

Digestive Tolerance and Side Effects

Active Ingredients and Formula

Dosage and Administration

Our Top Picks

1
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle
Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Rated 4.6 out of 5 stars
2,120
$74.99 Chewy Price
($2.50/ea)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.3/5
Great

Digestive Tolerance and Side Effects

4.1/5
Great

Active Ingredients and Formula

4.2/5
Great

Dosage and Administration

4.2/5
Great

Is this liver supplement right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: S-Adenosylmethionine, Silybin A+B

Packaging Type

Bottle
2
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count
Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rx Vitamins Hepato Support Liver Supplement for Cats & Dogs, 180 count

Rated 4.6 out of 5 stars
385
$46.99 Chewy Price
($0.27/ea)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.4/5
Great

Digestive Tolerance and Side Effects

4.4/5
Great

Active Ingredients and Formula

4.3/5
Great

Dosage and Administration

4.3/5
Great

Is this liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ingredients per capsule: Milk Thistle Extract 100 mg (EMed-MT premium providing 80% Silymarin and 30% silybinin) Inositol 20 mg Choline 20 mg DL-Methionine(pharmaceutical grade) 20 mg Pantothenic Acid (calcium pantothenate) 10 mg Vitamin B-1 (thiamine) 5 mg Vitamin B-2 (riboflavin) 5 mg Vitamin B-6 (pyridoxine) 5 mg Alpha Lipoic Acid 5 mg Vitamin B-12 (cyanocobalamin) 10 mcg Inactive ingredients: Gelatin‚ glycerin‚ silica and water

Food Flavor

Unflavored
3
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle
Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle

Wonder Paws Superhero Milk Thistle Liver & Kidney Health Liquid Supplement for Dogs, 2-fl oz bottle

Rated 4.4 out of 5 stars
319
$19.95 Chewy Price
($9.98/fl oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.3/5
Great

Digestive Tolerance and Side Effects

4.3/5
Great

Active Ingredients and Formula

4.4/5
Great

Dosage and Administration

4.4/5
Great

Is this liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Omega-3 Fatty Acids (from Salmon Oil) with 75 mg EPA and 85 mg DHA: 250 mg, Milk Thistle Extract (Sylibum marianum) (Seed): 50 mg, Curcumin C3 Complex Turmeric Root Extract (95% Curcuminoids) (Curcuma longa): 27 mg

Special Diet

Human-Grade, Natural
4
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle
Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle

Pet Wellbeing Milk Thistle Bacon Flavored Liquid Liver Supplement for Dogs, 4-oz bottle

Rated 4.5 out of 5 stars
271
$64.95 Chewy Price
($16.24/oz)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.5/5
Great

Digestive Tolerance and Side Effects

4.3/5
Great

Active Ingredients and Formula

4.2/5
Great

Dosage and Administration

4.3/5
Great

Is this liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Organic Milk Thistle Seed (Silybum Marianum)., Inactive Ingredients: Deionized Water, Natural Bacon Flavor (Glycerin-Based), Vegetable Glycerin

Food Flavor

Bacon, Liver, Meat
5
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count
SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count

SilymarinAdvanced S-Adenosylmethionine & Silybin Tablet Liver Health Supplement for Large Dogs, 30 count

Rated 4.7 out of 5 stars
43
$49.99 Chewy Price
($1.67/ea)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.6/5
Excellent

Digestive Tolerance and Side Effects

4.4/5
Great

Active Ingredients and Formula

4.3/5
Great

Dosage and Administration

4.3/5
Great

Is this liver supplement right for my pet?

Breed Size

Large Breeds

Lifestage

All Lifestages

Top Ingredients

Inactive Ingredients: Microcrystalline Cellulose, Hydroxypropyl Cellulose, Silicon Dioxide, Flavoring and Natural Coloring

Packaging Type

Bottle
6
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count
Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count

Wanderfound Pets Milk Thistle Liver Support Salmon & Bacon Flavor Dog Supplement, 100 count

Rated 4.5 out of 5 stars
384
$19.98 Chewy Price
($0.20/ea)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.3/5
Great

Digestive Tolerance and Side Effects

4.1/5
Great

Active Ingredients and Formula

4.4/5
Great

Dosage and Administration

4.3/5
Great

Is this liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Milk Thistle Seed Extract (Silybum Marianum) 100 mg, Artichoke Leaf Extract (Cyrana Scolymus) 25 mg, Dandelion Root Extract (Taraxacum Officinale) 25 mg, Yellow Dock (Root) (Rumex Crispus) 25 mg, Inactive: Microcrystalline Cellulose & Silicon Dioxide

Food Flavor

Salmon, Bacon, Meat, Seafood & Fish
7
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count
Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count

Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Large Dogs, 30 count

Rated 4.7 out of 5 stars
152
$54.99 Chewy Price
($1.84/ea)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.2/5
Great

Digestive Tolerance and Side Effects

3.7/5
Good

Active Ingredients and Formula

4.1/5
Great

Dosage and Administration

4.1/5
Great

Is this liver supplement right for my pet?

Breed Size

Medium Breeds, Large Breeds, Giant Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Actual Ingredients: S-Adenosylmethionine

Packaging Type

Box
8
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar
Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Herbsmith Herbal Blends Milk Thistle Powdered Dog & Cat Supplement, 75g jar

Rated 4.6 out of 5 stars
238
$25.99 Chewy Price
($0.35/g)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.3/5
Great

Digestive Tolerance and Side Effects

4.2/5
Great

Active Ingredients and Formula

4.3/5
Great

Dosage and Administration

4.4/5
Great

Is this liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Ground Milk Thistle (Supports Healthy Liver Function)

Food Flavor

Unflavored
9
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count
Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count

Zesty Paws Liver Support Bites Chicken Flavored Soft Chews Milk Thistle Supplement for Dogs, 90 count

Rated 4.3 out of 5 stars
403
$36.97 Chewy Price
($0.42/ea)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.2/5
Great

Digestive Tolerance and Side Effects

4.0/5
Great

Active Ingredients and Formula

4.1/5
Great

Dosage and Administration

4.1/5
Great

Is this liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Proprietary Liver Blend [Choline Bitartrate, N-Acetyl Cysteine (NAC), Dandelion Root], Milk Thistle Extract (Min. 80% Silymarin) (Silactive), Turmeric Extract

Food Flavor

Chicken, Poultry
10
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count
VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count

VetClassics Liver Support Soft Chews Dog & Cat Supplement, 120 count

Rated 4.2 out of 5 stars
141
$57.99 Chewy Price
($0.49/ea)
Promo, New Customers Only: Spend $49+, get $20 eGift Card

Our ratings

Effectiveness in Supporting Liver Health

4.1/5
Great

Digestive Tolerance and Side Effects

3.7/5
Good

Active Ingredients and Formula

3.9/5
Good

Dosage and Administration

3.9/5
Good

Is this liver supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients Per 3 g Soft Chew: Milk Thistle 200 mg, Dandelion Root 75 mg, Vitamin C (Calcium Ascorbate) 50 mg, Thiamine (Vitamin B1) 30 mg, Glutathione 20 mg

Food Flavor

Unflavored