Neo-Predef with Tetracaine Topical Powder for Dogs & Cats, 15-g

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Neo-Predef with Tetracaine is an antibacterial topical powder prescribed by your veterinarian to decrease the symptoms of certain ear and skin conditions in dogs, including ear infections, hot spots and skin infections found between the toes. It's also useful as a dusting powder for various minor cuts, lacerations and abrasions in both dogs and cats. It’s easy to apply—simply spread the powder over the affected area for quick relief.


Neo-Predef with Tetracaine Powder is indicated in the treatment or adjunctive therapy of certain ear and skin conditions in dogs and cats caused by or associated with neomycin-susceptible organisms and/or allergy.

Possible Side Effects

Do not give to pregnant animals, as corticosteroids may lead to birth defects. If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Drug & Food Interactions

Always tell your veterinarian about all medications and supplements your pet is taking before using Neo-Predef with Tetracaine.


Before applying any medication to the ear, examine the external ear canal carefully to be certain the tympanic membrane is not ruptured to avoid the possibility of spreading infection to the middle ear or damaging the cochlea or vestibular apparatus from prolonged contact.

  1. Prescribing Information

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  • Item Number
  • Brand


  • Dosage Measure

    Use according to your veterinarian's instructions.

  • For Use With

    Dogs & Cats

  • Generic Name

    Neomycin Sulfate, Isoflupredone Acetate, Tetracaine Hydrochloride

  • Brand


  • Product Form


  • Health Condition

    Ear Infections, Recovery, Wounds, Allergies

  • Drug Type

    Antibiotic, Anti-inflammatory, Sedative


Neomycon Sulfate, Isoflupredone Acetate, Tetracaine Hydrochloride.

Recommended Dosage

Apply this medication exactly as directed. In most instances a single daily application will be sufficient; however, it may be applied one to three times daily, as required.

Storage Instructions

Store in a dry place at controlled room temperature between 68° - 77°F.


What is Neo-Predef with Tetracaine Powder?

Neo-Predef is a medication that helps treatment of certain ear and skin problems.

What are the benefits of Neo-Predef with Tetracaine Powder?

Successful in the treatment of acute otitis externa in dogs Antibacterial powder with anti-inflammatory and soothing anesthetic effects. Adheres well to moist surfaces.

How is this medication given?

Follow treatment instructions carefully, since incorrect treatment can result in recurring infections and damage to the ear. Neo-Predef with Tetracaine is applied topically. Always follow the dosage instructions provided by your veterinarian. If you have difficulty applying the medication, contact your veterinarian.

The ear or area of skin should be thoroughly cleaned and dried before treatment. For the ear, remove any debris, crusty material, etc., with a suitable nonirritating ear cleaning solution. For the skin, use a skin cleansing solution to clean the lesion and adjacent area. Clip any excessive hair from the ear or treatment area as directed by your veterinarian.

How does this medication work?

Neo-Predef with Tetracaine is a combination of three drugs: neomycin, isoflupredone, and tetracaine. Neomycin is an antibiotic, isoflupredone is a corticosteroid, and tetracaine is a topical anesthetic. This combination of the three active ingredients work together at the site of infection or wound to kill bacteria, provide anesthetic relief, and to decrease inflammation. Isoflupredone has a potent anti-inflammatory effect and works blocking the production of substances that trigger allergic and inflammatory actions. Tetracaine has a numbing effect on the nerves in the area applied, to reduce discomfort.

What results can I expect?

Neo-Predef with Tetracaine works promptly to decrease the symptoms, and the effects last for hours. The tetracaine and isoflupredone help to soothe the area and prevent further trauma from licking or scratching at the site.

Customer Reviews
8 Reviews 8 Reviews 5 out of 5 Stars

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  • Will never be without this stuff again

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    This has been a game changer for our family. It works so well on so many injuries. We originally got the prescription for a dog with injuries after an altercation with another dog but we have used it on our dog that gets occasional hot spots that we have tried everything on with no success and this works perfectly. I can usually see improvement within 24 hours after the first application and rarely have to use it for more than two days. I also love that it is powder so it isn't messy and doesn't get everywhere. The dogs don't seem to want to lick it off as bad as other medicines either. Great product.

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  • Doberman Ear Crop

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    We have been using this product during the posting process of our dobie puppy's ears following a serious ear infection after the surgery. This powder has worked like a charm ever since, making our posting process stress free! Going on our 3rd week using it, we are very very happy.

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  • Seems to work as directed

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    For rear-end usage along with chlorhexidine solution 2% on my 14-year-old Golden who had a UTI and needed to also be shaved to keep area clean per vet. Chewy supplied at a much less price for both items.

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  • The ONLY thing that works.

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    For my dog's hot spots. I apply sparingly, ensure area clear of hair and dirt. After NUMEROUS treatments I no longer use anything else.

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  • Dog hot spots

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    This has helped tremendously with my senior fur baby’s hot spots by keeping them dry and comfortable for my pup.

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  • Perfect product for between my pets toes

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    My veterinarian prescribed this product for my dog when he got irritation between his toes after I shaved them. It is soothing and he doesn’t lick it off.

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  • Worked wonders

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    My dog has bed sores. Tried many different prescription ointments. Nothing worked. With this powder they are 50% better in 2 weeks

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  • Hot spot remedy

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    Excellent product for treating hot spots. Easy to apply.

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