Proin (phenylpropanolamine hydrochloride) Chewable Tablets for Dogs, 25-mg, 1 tablet

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About This Item

Details

  • Effectively treats urinary incontinence in dogs by strengthening the urethral sphincter muscle
  • Formulated with trusted Phenylpropanolamine Hydrochloride in a chewable, liver-flavored tablet
  • Easy administration and appealing to dogs. Typically shows results within a few weeks, helping prevent accidents and restoring quality of life for both owners and pets
  • Proin chewable tablets release the medication into the dog's system immediately, with level of absorption that may vary over time- multiple dosages provide the effective daily dosage prescribed
  • Not effective in dogs with incontinence due to neurologic disease or malformations

Ingredients

Instructions

FAQ

Learn More About Proin From Our Team of Experts

These Proin Chewable Tablets have the same efficacy as Proin Extended-Release Tablets.

Take control with PROIN

PROIN effectively treats urinary incontinence in dogs by strengthening the urethral sphincter muscle. Available in chewable tablets (25 mg, 50 mg, 75 mg), its liver-flavored formula makes administration easy and appealing to dogs and typically shows results within a few weeks, helping prevent accidents and restoring quality of life for both pets and owners.

Signs of Urinary Incontinence

  • Dripping, leaking urine 
  • Wet spots where the dog sleeps
  • Excessive licking of genitals
  • Red, irritated skin in the genital area

About PROIN

PROIN (phenylpropanolamine hydrochloride) is indicated for urinary incontinence control due to urethral sphincter hypotonus in dogs, available in twice-daily chewable tablets. Ask your veterinarian before using PROIN with any other medications.

Shop PROIN

Important Safety Information

PROIN IMPORTANT SAFETY INFORMATION: The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases, death, including euthanasia, has been reported. Sudden death was sometimes preceded by vocalization or collapse.

Instances of dogs chewing through closed vials of PROIN and eating the vial contents have been reported, in some cases resulting in overdose. Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN Chewable tablets. Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN Chewable tablets.

PROIN may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure.

The safe use of PROIN in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions.

Consumer Dog Owner survey conducted by PRN Pharmacal, December 2022 | 2025 PRN Pharmacal, Inc. All rights reserved.

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4.7
Rated 4.7 out of 5 stars
3464 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

90% Positive

Effectiveness

89% Positive

Ingredients

87% Positive

Long-Term Benefits

91% Positive

1187 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Jennifer on Jan 13, 2026

Very easy process- seamless with local vet office

I was told to order this medication by my local Veterinarian on the Chewy website. I was skeptical about how easy the process would be knowing they needed confirmation

I was told to order this medication by my local Veterinarian on the Chewy website. I was skeptical about how easy the process would be knowing they needed confirmation of a prescription from my local Veterinarian. It was easy! All right there. And the medicine is working! Even better than I expected. Within three days of starting on the medication, my older male dog was having no urine accidents most days. I am happy to have Chewy delivering us this medication.

Rated 5 out of 5 stars
By Terry on Jan 2, 2026

Great for mild incontinence

This is a product our vet prescribed for our now 8 year old spayed female lab. She started having mild leaks when she was about 3-4 with no other symptoms or issues

This is a product our vet prescribed for our now 8 year old spayed female lab. She started having mild leaks when she was about 3-4 with no other symptoms or issues and the vet felt this was the best option. She has had no problems since taking it. We also have another spayed female lab, she’s 3 and started having the same problem. Since she’s been on Proin there have been no issues, so we know it works!

Rated 5 out of 5 stars
By Carolyn on Jan 13, 2026

Really works!

My 10 1/2 YO 116 LB female Rottie has been taking Proin twice daily since she was about a year old. In 9+ years she has had an accident maybe 4 times at most. Possibly

My 10 1/2 YO 116 LB female Rottie has been taking Proin twice daily since she was about a year old. In 9+ years she has had an accident maybe 4 times at most. Possibly my fault?? I’m very conscientious that she gets her meds, but likely not 100% infallible over 9+ years. This is great stuff - it works!!!

Rated 5 out of 5 stars
By Deborah on Dec 22, 2025

Fast Turnaround!!!

This prescription was previously sent to me but it went to the wrong address. I called Chewy and a new prescription was sent out immediately to the correct address

This prescription was previously sent to me but it went to the wrong address. I called Chewy and a new prescription was sent out immediately to the correct address. My dog gets all her medications from Chewy and the fact that they were aware of that, knew the medication was important and didn’t hesitate to get a replacement out so my dog wouldn’t have to miss any days due to the problem is why I do business with Chewy!

Rated 4 out of 5 stars
By Dalton on Jan 14, 2026

Arrived quickly, but a little overhandled

Arrived a couple days faster than expected, but when I opened the medication there was a decent amount of powder in the jar. Im not sure if this was from when the

Arrived a couple days faster than expected, but when I opened the medication there was a decent amount of powder in the jar. Im not sure if this was from when the jar was filled, or if overhandling in transit caused the tablets to shed powder.

Rated 4 out of 5 stars
By Kathleen on Jan 17, 2026

Leaking has stopped

Hope was beginning to leak on a daily basis. No matter how many times she was taken out to potty. Poor thing was always wet and smelling. Since taking this tablet

Hope was beginning to leak on a daily basis. No matter how many times she was taken out to potty. Poor thing was always wet and smelling. Since taking this tablet twice a day she has not experienced leaking.

Rated 5 out of 5 stars
By Cynthia on Dec 31, 2025

Helps with k9 female incontinence

Sehr was leaking a lot while she was snoozing. Up to 4 times a day. She was tested for UTI But it came back negative. Her vet recommended Proin and wow, what a difference

Sehr was leaking a lot while she was snoozing. Up to 4 times a day. She was tested for UTI But it came back negative. Her vet recommended Proin and wow, what a difference. Been on it for 12 days and only 3 accidents compared to 4 a day. Highly recommend

Rated 5 out of 5 stars
By Mary on Dec 20, 2025

Tablets easy to cut and acceptable to the dog

Unfortunately, my dog Anjelo only took a few doses of this. It did not help his urinary incontinence. The incontinence was new. He became very ill about five days

Unfortunately, my dog Anjelo only took a few doses of this. It did not help his urinary incontinence. The incontinence was new. He became very ill about five days . He developed G.I. bleeding. The vet could not figure out what was wrong. He was almost 14. He died in his sleep the nextday.

Rated 5 out of 5 stars
By Caleb on Jan 4, 2026

Two year user. Proven results.

We started using Buddy Guard after removing three cancerous growths from our bump/growth prone 7 year old pitty. Two years later the number of bumps has decreased

We started using Buddy Guard after removing three cancerous growths from our bump/growth prone 7 year old pitty. Two years later the number of bumps has decreased and the bumps she has had are all benign.

Rated 1 out of 5 stars
By Julia on Jan 16, 2026

The shipping COST

I’m just not going to order anything else from Chewy. I’ve been a customer for over 10 years and now there are CHOICES where I still get great service and NO shipping

I’m just not going to order anything else from Chewy. I’ve been a customer for over 10 years and now there are CHOICES where I still get great service and NO shipping costs.