Simparica Chewable Tablet for Dogs 22.1-44 lbs (Mint Box), 1 Chewable Tablet (1-mos. supply)

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About This Item

Details

  • 35-Day Flea and Tick Prevention for Dogs: Simparica is a tasty, once-a-month chewable that protects your dog from fleas and ticks for 35 days, even if the next dose is a few days late.
  • Kills 6 Types of Ticks: Proven to kill Gulf Coast, Brown Dog, Deer, American Dog, Lone Star, and Asian Longhorned ticks.
  • Helps Prevent Lyme Infections: FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Fast-Acting Relief: Starts killing fleas within 3 hours and ticks within 8 hours. Kills adult fleas before they lay eggs to help stop infestations fast.
  • Tasty, Once-a-Month Chewable: Pork-liver flavored for easy dosing. Approved for dogs 6 months and older weighing at least 2.8 lbs, and backed by a 100% satisfaction guarantee on prevention.

Ingredients

Instructions

FAQ

Learn More About Simparica From Our Team of Experts

Protects Dogs From Ticks & Fleas for 35 days

Simparica is tasty pork liver-flavored, veterinarian-recommended monthly chew that protects your dog from fleas and ticks for a full 35 days.[1] It works fast and starts to kill fleas in 3 hours and ticks in 8 hours.[2] Simparica is approved for dogs 6+ months of age, weighing 2.8 lbs or more.

FDA-Approved to Prevent Lyme Infections*

Because it kills deer ticks, Simparica is FDA-approved to block infections that may cause Lyme disease. It kills 6 different types of ticks, including:

  • Gulf Coast Tick
  • Deer Tick
  • American Dog Tick
  • Lone Star Tick
  • Brown Dog Tick
  • Asian Longhorned Tick

Satisfaction Guaranteed

Simparica comes with a 100% satisfaction guarantee on prevention—so you can feel confident choosing fast, reliable protection. It’s a simple way to stay proactive about your dog’s care, with support you can count on.

Protect Your Dog & Earn Rewards From Zoetis

Your 6-or 12-count Simparica purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future vet care and more! Learn More at zoetispetcare.com/rewards

About Zoetis, the Makers of Rimadyl

At Zoetis, we’ve helped pets live their best lives for over 70 years. Zoetis offers a comprehensive range of products to support your pet’s health—from pest prevention and pain management to allergic itch relief and more. Know that we’ll always be here for you and your pet, no matter what.

Shop Zoetis

IMPORTANT SAFETY INFORMATION

Simparica is for use only in dogs 6 months of age and older. Simparica, which contains sarolaner, a member of the isoxazoline class, may cause neurologic signs such as tremors, unsteadiness, and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding, or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaPI.com.

*Data on file, Zoetis Services LLC.

References:Six RH, Liebenberg J, Honsberger NA, Mahabir SP. Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ctenocephalides felis on dogs. Parasit Vectors. 2016;9:90Honsberger NA, Six RH, Heinz TJ, et al. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67–72 (AR-04287).

SMP-00748

4.8
Rated 4.8 out of 5 stars
1309 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

91% Positive

Effectiveness

91% Positive

Ingredients

90% Positive

Long-Term Benefits

92% Positive

442 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 1 out of 5 stars
By Suzanne on Jan 13, 2026

Sent wrong med! Still not resolved!

This was an order for three meds. Carprofen, Simparica, and Interceptor. You sent for carprofen but failed to send the interceptor and instead sent two Simparica

This was an order for three meds. Carprofen, Simparica, and Interceptor. You sent for carprofen but failed to send the interceptor and instead sent two Simparica. I wrote you about this, the reply did not address the issue, and then they canceled it without even telling me! So I have written you a second time and have not gotten any reply! I have been a client for a number of years but I am about to get rid of you! This is the second time in recent months that you have screwed up my order!


Rated 1 out of 5 stars
By Carol on Oct 24, 2025

May cause seizures!!! Beware!!

I used Simparica for years for all of my dogs. However I suspect (and have read reports) that it contains ingredients that can cause seizures in dogs. Unfortunately

I used Simparica for years for all of my dogs. However I suspect (and have read reports) that it contains ingredients that can cause seizures in dogs. Unfortunately I was unaware of this in time to prevent my dogs from being exposed to it. Both of my dogs developed epilepsy. They are two different breeds and were otherwise healthy until they were given Simparica for an extended period (over two years). Both my vet and my neurologist confirmed that this is a growing issue with this product. Unfortunately once a beloved pet develops epilepsy it is not reversible. One of our dogs died in our arms during a seizure. The other must have her medicine every 6 hours or she will start seizures. We have switched to a natural flea prevention (available through CHEWY) which has been very effective and was recommended by our neurologist.


Rated 5 out of 5 stars
By Barbara on Jan 18, 2026

Super Fast

Going out of town when my auto ship was due to be delivered. Moved my auto ship date up and it wad here before I went out of town and Louie didn't miss a dose.

Going out of town when my auto ship was due to be delivered. Moved my auto ship date up and it wad here before I went out of town and Louie didn't miss a dose.


Rated 5 out of 5 stars
By Janet on Jan 8, 2026

Top Notch Customer Service

US post office returned the rx and it took a month to get it back. I was in a panic, but my vet relented and called Chewy and Chewy expedited the order. Lovely

US post office returned the rx and it took a month to get it back. I was in a panic, but my vet relented and called Chewy and Chewy expedited the order. Lovely people


Rated 1 out of 5 stars
By Debra on Oct 28, 2025

Rude customer service agent

Your customer service agent. She blamed me for everything thing that went wrong with the order. If you’re interested in what I’m saying listen to our phone call

Your customer service agent. She blamed me for everything thing that went wrong with the order. If you’re interested in what I’m saying listen to our phone call. Being they say “this call is being monitored for training purposes”. She was a terrible customer service representative. Cause chewy to loose a long time customer. Deleted everything on my phone regarding chewy. Thanks for nothing.


Rated 5 out of 5 stars
By Randy on Dec 19, 2025

Fast and efficient service

My order was shipped promptly and efficiently. In addition, emails keeping me apprised of the status and shipping was accurate and greatly appreciated!!!!!!

My order was shipped promptly and efficiently. In addition, emails keeping me apprised of the status and shipping was accurate and greatly appreciated!!!!!!


Rated 5 out of 5 stars
By Jeffrey on Dec 23, 2025

Sooooo Easy

Chewy contacted the vet so we didn't have to. Kept us posted along the way and then shipped super fast ( as usual!)

Chewy contacted the vet so we didn't have to. Kept us posted along the way and then shipped super fast ( as usual!)


Rated 5 out of 5 stars
By Jeanna on Jan 19, 2026

Price!

Buying the three pack on chewy was way less expensive than buying it at my vet's office

Buying the three pack on chewy was way less expensive than buying it at my vet's office


Rated 5 out of 5 stars
By Beverly on Dec 1, 2025

It Works!

I used Conforti for the last 10 years, but my dogs hated this taste. As soon as I gave them.simparica the fleas died instantly

I used Conforti for the last 10 years, but my dogs hated this taste. As soon as I gave them.simparica the fleas died instantly


Rated 5 out of 5 stars
By Avis on Oct 20, 2025

Quick service

All items I've ever purchased from Chewy come to my house within a few days even those needing vet approval. I find it comforting to know that I can get my dog's

All items I've ever purchased from Chewy come to my house within a few days even those needing vet approval. I find it comforting to know that I can get my dog's medication as soon as it's needed!