Simparica Chewable Tablet for Dogs 11.1-22 lbs (Orange Box), 1 Chewable Tablet (1-mos. supply)

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About This Item

Details

  • 35-Day Flea and Tick Prevention for Dogs: Simparica is a tasty, once-a-month chewable that protects your dog from fleas and ticks for 35 days, even if the next dose is a few days late.
  • Kills 6 Types of Ticks: Proven to kill Gulf Coast, Brown Dog, Deer, American Dog, Lone Star, and Asian Longhorned ticks.
  • Helps Prevent Lyme Infections: FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Fast-Acting Relief: Starts killing fleas within 3 hours and ticks within 8 hours. Kills adult fleas before they lay eggs to help stop infestations fast.
  • Tasty, Once-a-Month Chewable: Pork-liver flavored for easy dosing. Approved for dogs 6 months and older weighing at least 2.8 lbs, and backed by a 100% satisfaction guarantee on prevention.

Ingredients

Instructions

FAQ

Learn More About Simparica From Our Team of Experts

Protects Dogs From Ticks & Fleas for 35 days

Simparica is tasty pork liver-flavored, veterinarian-recommended monthly chew that protects your dog from fleas and ticks for a full 35 days.[1] It works fast and starts to kill fleas in 3 hours and ticks in 8 hours.[2] Simparica is approved for dogs 6+ months of age, weighing 2.8 lbs or more.

FDA-Approved to Prevent Lyme Infections*

Because it kills deer ticks, Simparica is FDA-approved to block infections that may cause Lyme disease. It kills 6 different types of ticks, including:

  • Gulf Coast Tick
  • Deer Tick
  • American Dog Tick
  • Lone Star Tick
  • Brown Dog Tick
  • Asian Longhorned Tick

Satisfaction Guaranteed

Simparica comes with a 100% satisfaction guarantee on prevention—so you can feel confident choosing fast, reliable protection. It’s a simple way to stay proactive about your dog’s care, with support you can count on.

Protect Your Dog & Earn Rewards From Zoetis

Your 6-or 12-count Simparica purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future vet care and more! Learn More at zoetispetcare.com/rewards

About Zoetis, the Makers of Rimadyl

At Zoetis, we’ve helped pets live their best lives for over 70 years. Zoetis offers a comprehensive range of products to support your pet’s health—from pest prevention and pain management to allergic itch relief and more. Know that we’ll always be here for you and your pet, no matter what.

Shop Zoetis

IMPORTANT SAFETY INFORMATION

Simparica is for use only in dogs 6 months of age and older. Simparica, which contains sarolaner, a member of the isoxazoline class, may cause neurologic signs such as tremors, unsteadiness, and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding, or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaPI.com.

*Data on file, Zoetis Services LLC.

References:Six RH, Liebenberg J, Honsberger NA, Mahabir SP. Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ctenocephalides felis on dogs. Parasit Vectors. 2016;9:90Honsberger NA, Six RH, Heinz TJ, et al. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67–72 (AR-04287).

SMP-00748

4.8
Rated 4.8 out of 5 stars
2036 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

92% Positive

Effectiveness

90% Positive

Ingredients

89% Positive

Long-Term Benefits

90% Positive

690 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 4 out of 5 stars
By Dale on Dec 26, 2025

Sales Tax should not be charged

Charging sales tax on a prescription, never heard of it. Now the price becomes more expensive than what my vet charged. Chewy is not saving me money, it's actually

Charging sales tax on a prescription, never heard of it. Now the price becomes more expensive than what my vet charged. Chewy is not saving me money, it's actually costing more because of the sales tax charged. Online or vets office should make no difference.


Rated 1 out of 5 stars
By lorireber2 on Jan 8, 2026

Wrong item

I was supposed to get simpatico trio Simparica. Both or 411.12 22 pound 6 count which is correct. Can I return the wrong one and can you send me the new one ple

I was supposed to get simpatico trio Simparica. Both or 411.12 22 pound 6 count which is correct. Can I return the wrong one and can you send me the new one please?


Rated 4 out of 5 stars
By Lynn on Dec 19, 2025

Work well, but not all the doggies like them

We’ve been using this for years and have no flees or ticks. The only bad thing is the cost and the taste. Some of my doggies need to have them wrapped in cheese

We’ve been using this for years and have no flees or ticks. The only bad thing is the cost and the taste. Some of my doggies need to have them wrapped in cheese in order to eat them.


Rated 5 out of 5 stars
By Susan on Dec 22, 2025

Great company

The item is just their regular flea meds but the company customer service is outstanding!! I get monthly deliveries and if something isn't right they correct it

The item is just their regular flea meds but the company customer service is outstanding!! I get monthly deliveries and if something isn't right they correct it immediately.


Rated 5 out of 5 stars
By Debi on Dec 19, 2025

Works! Fleas gone.

Mine got fleas and tried quite a few solutions; flea dips, other meds, flea collar. Nothing was working. Staying on this has worked great. No unwanted side effe

Mine got fleas and tried quite a few solutions; flea dips, other meds, flea collar. Nothing was working. Staying on this has worked great. No unwanted side effects.


Rated 5 out of 5 stars
By Laurielle on Nov 16, 2025

Effective Flea & Tick

This is the only solution we’ve found to keep fleas off our dogs here in Florida. Fleas are built differently this far south and we struggled for months to get rid

This is the only solution we’ve found to keep fleas off our dogs here in Florida. Fleas are built differently this far south and we struggled for months to get rid of them. Pretty much as soon as we gave them Simparica, the fleas vanished.


Rated 5 out of 5 stars
By Jeanine on Nov 7, 2025

Does the Job

I switched to this because my vet recommended it. I also love that I don't have to give a separate pill for heartworm. Once a month and no fleas. My dog doesn't

I switched to this because my vet recommended it. I also love that I don't have to give a separate pill for heartworm. Once a month and no fleas. My dog doesn't seem to have any problems with this medication.


Rated 5 out of 5 stars
By Dionna on Dec 7, 2025

Fast Delivery

Chewy is awesome!!! They track when our pets are due for medications and assist with obtaining prescriptions from our Vet Services. I love Chewy!

Chewy is awesome!!! They track when our pets are due for medications and assist with obtaining prescriptions from our Vet Services. I love Chewy!


Rated 5 out of 5 stars
By Merlin on Dec 5, 2025

No fleas on my dogs

Been using it for years for my 132 lb Flat Coat Retriever and now for our 18 lb Terrier mix that is a rescue and 14 yrs. old.

Been using it for years for my 132 lb Flat Coat Retriever and now for our 18 lb Terrier mix that is a rescue and 14 yrs. old.


Rated 1 out of 5 stars
By John on Sep 4, 2025

Delivery

This is the second time I have contacted chewy and the third time I have contacted FedEx. My orders are left everywhere except where they shouldbe left in the mailbox

This is the second time I have contacted chewy and the third time I have contacted FedEx. My orders are left everywhere except where they shouldbe left in the mailbox on the street at the end of the driveway. FedEx should deliver to my home a number of homes in my have had issues with FedEx doing the same thing. One more time and I will change where I order so I do not have to use FedEx. Thank you.