Heartgard Plus Chew for Dogs, up to 25 lbs, (Blue Box)

By Heartgard
Rated 4.9253 out of 5 stars
Prescription Item
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Heartgard Plus Chew for Dogs, up to 25 lbs, (Blue Box), 1 Chew (1-mo. supply) slide 1 of 11
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Heartgard Plus Chew for Dogs, up to 25 lbs, (Blue Box), 1 Chew (1-mo. supply) slide 1 of 11

$9.99Chewy Price
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Bundle Heartgard Plus with NexGard and Save 15% Off at Checkout With Code: HGNG15

Frequently Bought Together
Rated 4.9106 out of 5 stars
$63.99Chewy Price

Bundle Heartgard Plus with NexGard and Save 15% Off at Checkout With Code: HGNG15

Total Price: $0.00

About This Item

For use in animals only. Heartgard Plus Chew for Dogs, up to 25 lbs. is a heartworm preventative that kills heartworms and also helps treat and control roundworms and hookworms. It comes in a delicious once-a-month, real-beef chew that dogs love and is safe for puppies 6 weeks and older. Head back to the dog park, reassured that your dog is protected from nasty parasites with this heartworm preventative that's trusted over 2 billion times! Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Learn More About Heartgard From Our Team of Experts

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
BlueUp to 25 lbs68 mcg Ivermectin & 57 mg PyrantelAdministered orally at monthly intervals✓-Click Here
Green26 to 50 lbs136 mcg Ivermectin & 114 mg PyrantelAdministered orally at monthly intervals✓-Click Here
Brown51 to 100 lbs272 mcg Ivermectin & 227 mg PyrantelAdministered orally at monthly intervals✓-Click Here

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About HEARTGARD Plus Soft Chews

Protection Dogs Love

HEARTGARD Plus (ivermectin/pyrantel) prevents the invisible and potentially deadly threat of heartworm disease. HEARTGARD Plus not only prevents heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms. Plus, it comes as a real-beef chew with a taste dogs love.

Recommended by Vets

Whether for their patients or their own dogs, HEARTGARD Plus is recommended by vets. Safe for puppies as young as 6 weeks of age with no minimum weight requirement, HEARTGARD Plus delivers safe but powerful protection against heartworm disease. Trusted over 2 billion times, with HEARTGARD Plus, you can rest easy knowing your dog is protected.

Dogs Love Real-Beef Chews

Preventing heartworm disease never tasted so good! So, forget wrapping pills in sliced cheese, and put away the peanut butter. Giving real-beef HEARTGARD Plus chewables is easy because dogs love the taste, making monthly dosing an enjoyable experience.

All Dogs Are at Risk Year-Round

Inside or out, year-round, all dogs are at risk for heartworm disease no matter where you live in the US. When it comes to heartworm disease, treatment can be expensive, traumatic, and is not always effective. Instead, protect your dog every month with delicious HEARTGARD Plus.

Product Guide

HEARTGARD Plus offers protection for dogs in most sizes and weights. Choose the option best fitted for your pet.

Up to 25 lbs

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26 - 50 lbs

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51 - 100 lbs

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HEARTGARD Plus (ivermectin/pyrantel) is well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurological side effects have rarely been reported. For more information, contact your veterinarian, or refer to the full prescribing information.


Data on file at Boehringer Ingelheim. HEARTGARD® Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA 140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc. Prevent Heartworms in Dogs, Cats, and Ferrets Year-Round _FDA Consumer Updateshttps://www.fda.gov/consumers/consumer-updates/preventheartworms-dogs-cats-andferrets-yearround#:~:text=That’s%20one%20reason%20veterinarians%2often,giving%20medication%20during%20this%20season. Accessed 2/8/2021.


HEARTGARD Plus is a monthly, real-beef chewable that prevents heartworm disease and treats and controls hookworms and roundworms. As a vet-recommended heartworm disease prevention, HEARTGARD Plus is safe for all breeds and sizes of dogs, you can begin protecting your puppy as young as six weeks of age. The great taste makes monthly dosing a delight. Ask your veterinarian about preventing heartworm disease in your dog with HEARTGARD Plus.


Just one bite from an infected mosquito could put your dog at risk for heartworm disease, but HEARTGARD Plus offers the protection your dog needs. This heartworm preventive is made with real beef and has a savory taste, making it the #1 dog-preferred chew. HEARTGARD Plus makes protecting your dog year-round easy and enjoyable month after month.*



  1. Data on file at Boehringer Ingelheim.
  2. HEARTGARD® Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA 140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.
  3. Heartworm prevalent in South, expanding in other hot spots. American Veterinary Medical Association. https://www.avma.org/javma-news/2020-08-01/heartwormprevalent-south-expanding-other-hot-spots. Accessed December 23, 2021.
  4. Heartworm Parasite Prevalence Maps. Companion Animal Parasite Council. https://capcvet.org/maps/#/2020/all/heartworm-canine/dog/united-states. Accessed November 18, 2021.
  5. Heartworm Guidelines. American Heartworm Society. https://www.heartwormsociety.org/veterinary-resources/ american-heartworm-society-guidelines. Accessed December 23, 2021.

ReviewsWrite a Review

Rated 4.9253 out of 5 stars
1098 Reviews
Would recommend to a friend

1095 Customer Reviews

Rated 5 out of 5 stars
By ZiggyandMikimoto on Apr 21, 2022


Quality product, easy to obtain and shipped quickly so I don't get off schedule. Love CHEWY contacting my vet, notifying of vet response and then of course when it is shipped and delivered. Super Easy!! Thank you, after 2 cervical neck fusions and a lumbar fusion scheduled your site is very helpful with meds, treats, food and other needs in a timely manner when I am not able to get out and drive around. Thank you for the service!!

Rated 5 out of 5 stars
By SharonM on Apr 25, 2022

Perfect for my doggy!

I have always had problems with getting my little one to take his heartgard meds but this one has been perfect for him as he eats it up with me not trying to trick him to it. I also loved that Chewy's reaches out to my vet to ensure they get the approvals on behalf of me so it's an easy process to get this on a regular basis. Thank you Chewy's.

Rated 3 out of 5 stars
By Wolf on Apr 14, 2022

Heartgard chewables

Not sure why it was felt this product had to be made into a chewable. My dog did not like the flavor at all. I ended up having to cut it into multiple pieces and putting it in peanut butter - just like I did with the pills. I can't evaluate effectiveness as a heartworm preventative, but I'll go back to the old-fashioned pill when I refill my Rx.

Rated 5 out of 5 stars
By Dallas on May 18, 2022

CHEWY Home Delivery

I love the autoship feature and home delivery at CHEWY. Saves me the trouble of lugging heavy bags for my furbabies!! AND, of course, the reminders and autoship of their Heartguard and other products is amazing!!

Rated 5 out of 5 stars
By Tickerpicker on May 6, 2022

Not my Walter

Prevention and protection guaranteed. Easy to give . . .Walter thinks it’s an extra treat. The product’s name says it all. Heart guard for Walter and my peace of mind.

Rated 5 out of 5 stars
By Cristina on Apr 2, 2022

My dog thinks its a tasty treat

My mini doodle is super picky, she usually needs any medication hidden in a peanut butter pill pocket, but she will eat this chew by itself in 2 seconds, she thinks it's a treat and she must love the flavor because so far, so good. Highly recommend.

Rated 5 out of 5 stars
By Bebe on May 17, 2022

No fussing !!

She chews it easily, never spits it out!! Easy to administer, no chasing around the house. If you have a problem just rub peanut butter on it!

Rated 5 out of 5 stars
By Curlytop on Apr 20, 2022

Great Protection

My regimen for small dogs has always been Heartgard Plus and Frontline Plus each month. My dogs have never had a reaction from either, and we've always been heart worm and pest free.

Rated 5 out of 5 stars
By Duke on May 2, 2022

Works great!

So far using chewy to order my dogs heartguard has been seemless. No issues, delivered online time, good to go. Will continue to order through chewy.

Rated 5 out of 5 stars
By Herme on May 19, 2022

Pups love these!

My pups eat the heartgard as if it was a special treat. I give the 51-100# and 0-25# to my pups because they are over 100#.