Vetoquinol Zylkene Capsules Calming Supplement for Dogs, 30 count

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At a Glance

  • Calming
  • All Lifestages
  • Medium Breeds
  • Large Breeds

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About This Item

Details

  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your dog.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for dogs with sensitive tummies; used by veterinarians and dog behaviorists worldwide.
  • Formula comes in 225 mg capsules that can be given by mouth, or opened and mixed with a meal.

Ingredient Information

Instructions

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Questions & Answers

8 Customer Questions

Can y give zylkene and valerian root or other tranquilizer type herb?

Answer by Chewy • Jul 09, 2018
The non-drowsy formula uses alpha-casozepine, a natural ingredient found in cow’s milk, to help balance the stress reactions of dogs safely and with no tranquilizing or sedating effects. We suggest consulting with your vet before supplementing this with an additional behavior support alternatives.

Will this help I have a German Shepard who very wild to where I can't even try to hold him still to groom his hair.

Answer by Chewy • Mar 25, 2018
Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training. Consult your veterinarian before giving your pet Zylkene.

When are you supposed to give this to your dog if you’re flying?

Answer by Chewy • Aug 03, 2018
Short-term use: Use Zylkene for 1 - 2 days before a planned event or change in environment. Some animals may need earlier administration (5 - 7 days).

Can this be given daily long term? Can dogs build up a tolerance if given daily? Or should it be used for times of high stress?

Answer by Chewy • Jan 07, 2020
This product is intended for intermittent or supplemental feeding only. Consult your veterinarian before giving your pet Zylkene. Follow the recommended administration on the package, unless otherwise instructed by your veterinarian.
Reviews
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4.0
Rated 4 out of 5 stars
173 Ratings
Terms & Conditions

121 Customer Reviews

Rated 5 out of 5 stars
By Cyndi on Jan 14, 2026

Great for Riley!

My Golden Retriever is very reactive and has PTSD from falling down our stairs twice. Ive had him on prescription meds for about 4 months and didnt really work for

My Golden Retriever is very reactive and has PTSD from falling down our stairs twice. Ive had him on prescription meds for about 4 months and didnt really work for him. Ive done CBD and other holistic remedies I tried Zylkene and in two days I saw a slight difference. Its been 2 weeks now and with some tweaks in how we react to his anxiousness he's doing so much better. Finally a natural remedy that works for him

Rated 5 out of 5 stars
By Elizabeth on Nov 21, 2025

This Works

On the recommendation of our veterinarian, we tried this for our 43 pound rescue that we’ve had for a year. She has made tremendous gains over this year, but Zylkene,

On the recommendation of our veterinarian, we tried this for our 43 pound rescue that we’ve had for a year. She has made tremendous gains over this year, but Zylkene, at half the dose for her weight, has been a game changer. She walks more and spends less time sniffing which I know was calming for her, but meant she wasn’t getting as much exercise. She is less bothered by truck noises and people she doesn’t know. The ONLY fault I find is with the packaging. Is there seriously not a more efficient way to send this tiny bottle when it’s the only thing in my order?

Rated 5 out of 5 stars
By Monarae on Nov 27, 2025

Better than a Chill Pill

My dog anxiety worsens with each year. I try to give her Rx-Trazadone sparingly as she has myasthenia gravis so need to be careful with drugs. In the past the OTC

My dog anxiety worsens with each year. I try to give her Rx-Trazadone sparingly as she has myasthenia gravis so need to be careful with drugs. In the past the OTC calming pills have worked but now, no so much. My vet recommended the Vetoquinol & I saw improvement almost immediately. Is she a 100% chill dog - never! She's a border collie, LOL. But compared with my other 2 "chill" border collies she's as chill as she can be during fireworks & thunderstorms.

Rated 5 out of 5 stars
By Roberta on Nov 16, 2025

Highly recommend this product

We were adopted by a dog who was found wandering for no one knows how long. She came with a lot of emotional issues and the vet at rescue had prescribed trazodone

We were adopted by a dog who was found wandering for no one knows how long. She came with a lot of emotional issues and the vet at rescue had prescribed trazodone. I wanted to get her off of the medication and onto something healthier. This is a remarkable item. The change in her behavior been enlarged part from the medication, calming her enough to accept our love and attention. We highly recommend this to others who have similar problems with their dogs. It is healthy and our vet was happy to see her off the other medication.

Rated 2 out of 5 stars
By Lily on Sep 15, 2025

Wish it worked better

I got this as my vet and I noticed my dog having pretty bad anxiety (he’s a husky) with that being said he is my younger husky just a tab bit over two years old

I got this as my vet and I noticed my dog having pretty bad anxiety (he’s a husky) with that being said he is my younger husky just a tab bit over two years old and me and my vet did not want to put him on medication if a supplement would help and or benefit trey. I got two different supplements and for the price I would skip out on this one I tried him on each one for 30 days to see which one would help trey more and this one was also harder for me to administer as this is a capsule as the other is a chewable tablet in this case Trey think the other one is a treat. But over all I really wished this work and hope this benefits your dog if you choose to purchase!

Rated 2 out of 5 stars
By mary on Nov 10, 2025

Short lived

Helped significantly for about 6 days but after that not do much. My dog developed the runs on day 4. Expensive test buying the smallest quantity plus then anti

Helped significantly for about 6 days but after that not do much. My dog developed the runs on day 4. Expensive test buying the smallest quantity plus then anti diarrhea pills (apparently this is a known side effect)

Rated 4 out of 5 stars
By Sandra on Nov 1, 2025

Pretty good!

This worked pretty good. I gave it with her food before a rain storm. She was way more calm. I gave the whole capsule but you can open capsule and serve as a powder

This worked pretty good. I gave it with her food before a rain storm. She was way more calm. I gave the whole capsule but you can open capsule and serve as a powder with food.

Rated 4 out of 5 stars
By Corinne on Jan 7, 2026

Not sure of the effect

This might work on other dogs but didn’t seem to help my foster dog.

This might work on other dogs but didn’t seem to help my foster dog.

Rated 5 out of 5 stars
By Pamela on Aug 20, 2025

This product works.

This product was recommended by a Veterinary Behavioralist. I initially purchased the 75 mg for my 15 lb. cat and gave 2 capsules 1 x day. The vet recommended

This product was recommended by a Veterinary Behavioralist. I initially purchased the 75 mg for my 15 lb. cat and gave 2 capsules 1 x day. The vet recommended giving 1/2 225 mg. 1 x day. The 75 mg. 2 times a day worked best. I will be going back to that with Vet's approval.

Rated 5 out of 5 stars
By Olga on Oct 28, 2025

This works for my pup!

I like that it’s a very natural source, made from a milk source. My pup tolerated this very well. Highly recommend!

I like that it’s a very natural source, made from a milk source. My pup tolerated this very well. Highly recommend!