VETOQUINOL Zylkene Capsules Calming Supplement for Dogs, 14 count -

Vetoquinol Zylkene Capsules Calming Supplement for Dogs

By Vetoquinol
Rated 3.8434 out of 5 stars

$22.47Chewy Price
$22.99Chewy Price
$21.35Autoship Price
Autoship (Save an extra 5%)

Why Autoship?

  • Save 5% on all future Autoship orders
  • Set your schedule based on your pet's needs
  • No fees, no commitments - skip, change or cancel anytime.

In Stock
FREE 1-3 day shipping over $49

About This Item


  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your dog.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for dogs with sensitive tummies; used by veterinarians and dog behaviorists worldwide.
  • Formula comes in 225 mg capsules that can be given by mouth, or opened and mixed with a meal.

See More

Nutritional Information

Feeding Instructions


Play Video: Learn More About Vetoquinol From Our Team of Experts
Learn More About Vetoquinol From Our Team of Experts

Questions & Answers

8 Customer Questions

Can y give zylkene and valerian root or other tranquilizer type herb?
Answer by ChewyJul 09, 2018
The non-drowsy formula uses alpha-casozepine, a natural ingredient found in cow’s milk, to help balance the stress reactions of dogs safely and with no tranquilizing or sedating effects. We suggest consulting with your vet before supplementing this with an additional behavior support alternatives.

Will this help I have a German Shepard who very wild to where I can't even try to hold him still to groom his hair.
Answer by ChewyMar 25, 2018
Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training. Consult your veterinarian before giving your pet Zylkene.

Can this be given daily long term? Can dogs build up a tolerance if given daily? Or should it be used for times of high stress?
Answer by ChewyJan 07, 2020
This product is intended for intermittent or supplemental feeding only. Consult your veterinarian before giving your pet Zylkene. Follow the recommended administration on the package, unless otherwise instructed by your veterinarian.

When are you supposed to give this to your dog if you’re flying?
Answer by ChewyAug 03, 2018
Short-term use: Use Zylkene for 1 - 2 days before a planned event or change in environment. Some animals may need earlier administration (5 - 7 days).

ReviewsWrite a Review

Rated 3.8434 out of 5 stars
83 Reviews
Would recommend to a friend

83 Customer Reviews

Filter by reviews that mention

Rated 5 out of 5 stars
By ACTA on Jan 11, 2023

This works

I have a very excitable terrier mix, I've used other calming supplements but I found they were not very effective. This particular supplement seems to work really well. We had flooring replaced in our house, lots of noise, lots of disruption and she did really well. I could get her to stop barking, to go lay down in her quiet place. She seemed less anxious overall.

Rated 1 out of 5 stars
By Michele on Jul 12, 2022

Can't use for my dog

Bought this for my dogs fireworks Anxiety. It didn't help and gave her bad Diarrhea. It was also very expensive and now I can't even use it.

Rated 5 out of 5 stars
By Lauren on Mar 10, 2022

this saved my cat

This saved my cat he was so anxious he would get aggressive. I felt bad for him and got him put on fluoxetine but didn’t see much of a change. I was beginning to loose hope but the vet said to put him on this and it has seriously saved him. He still has his personality but he is not nearly as anxious and can relax.

Rated 5 out of 5 stars
By Sugar on Apr 23, 2022

Calming her down

Works really good puts here to sleep I use it all the time

Rated 1 out of 5 stars
By Kebees42 on Mar 10, 2022

Dog calming pills

It was a waste of money. If anything it made my dog worse. I will never buy again.

Rated 1 out of 5 stars
By MJ19 on Dec 8, 2021

Pass on this

I paid almost $50 for 30 pills. I have 2 dogs with anxiety and thought this would help. Went through the whole bottle super fast, noticed no change in either dog. Too much money and doesn't even have any effect.

Rated 5 out of 5 stars
By mmjc on Oct 20, 2021

this medication works

I have three dogs: one girl and two boys. The girl is 10 lbs; the boys are 14 pounds each. Small dogs. We got to the point where the boys could not even look at each other without attacking one another. I would be sitting on the couch reading a book, and suddenly, the boys would start ferociously attacking each other. It made life at home extremely difficult. My girl dog was scared and hid. she developed anxiety bc of this. We had no idea what to do. As soon as both of them began to take this medication, both of their temperaments changed. They were dog piling on top of each other and falling asleep, faces touching. They were playing with toys with each other. They followed each other everywhere. They were like two completely different dogs. I thought it was going to change their personalities dramatically or turn them into little zombies. That was not the case. It did make them sleepier than usual. For the most part, they were their upbeat selves, and they were very affectionate towards each other. If you were ever in this situation, I would absolutely try this medication.

Rated 5 out of 5 stars
By BrittGuy on Aug 24, 2021

Worth every penny

A friend of mine from our vet clinic recommended CBD and this product - but had never used it. These two ‘items’ were recommended, because she knows my reluctance to use heavier drugs. Dog: 4 1/2yo springer that has always moaned and groaned when in the car. Wife and I had a 900 mile trip planned. Results: Day1: used over her breakfast food. Traveled GREAT. Day 2: less than 5hr drive-didn’t use. Traveled TERRIBLE! Return trip day 1: used, traveled great Day 2: used, traveled great! Relaxed in the car - usually energy at stops! Is this a perfect run ‘drug trial’ - no. But I will definitely use again based on my experience!

Rated 1 out of 5 stars
By bbbb on Nov 7, 2021

didn’t calm my dog down

Gave one capsule per day as directed but there was no noticeable change in her behavior

Rated 5 out of 5 stars
By Richardsharon4 on Jul 24, 2021

Good calming supplement

This is a calming supplement recommended by our veterinarian for our cat Fluffy who has feline PTSD. Combined with TLC, she's gradually become calmer and easier to handle.