Vetoquinol Zylkene Capsules Calming Supplement for Dogs

By Vetoquinol
Rated 3.6934 out of 5 stars


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$76.99Chewy Price
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Frequently Bought Together

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$18.99Chewy Price
Total Price: $114.97

About This Item


  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your dog.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for dogs with sensitive tummies; used by veterinarians and dog behaviorists worldwide.
  • Formula comes in 450 mg capsules that can be given by mouth, or opened and mixed with a meal.

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Nutritional Information

Feeding Instructions


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Questions & Answers

11 Customer Questions

Can this product be used long term OR only situational?
Answer by ChewyOct 26, 2022
Zylkene supplement can be used long term or short term. It has proven to be safe and effect.

will this make my dog less playful and get deprest
Answer by ChewyApr 19, 2018
This supplement will not cause your dog to be depressed. The non-drowsy formula uses alpha-casozepine, a natural ingredient found in cow’s milk, to help balance the stress reactions of dogs safely and with no tranquilizing or sedating effects.

Generally speaking, how long is a Zylkene capsule effective in a dog? There are chews available that work for about four hours, and I am looking for something that will assist a bit longer in the day. Thank you.
Answer by ChewySep 10, 2018
The results will vary from pet to pet, but generally speaking the effects last most of the day (4+ hours).

My vet prescribed one pill 1-2 hours before the car ride that stresses my dog out. I’m reading that it should be days, not hours?
Answer by ChewyJul 11, 2019
This dog supplement recommends dogs 33 - 65 pounds to have 1 capsule daily. For dogs 66 - 132 pounds, feed 2 capsules daily. We recommend consulting your Veterinarian to see what would be a good fit for your pet.

ReviewsWrite a Review

Rated 3.6934 out of 5 stars
137 Ratings
Would recommend to a friend

137 Customer Reviews

Rated 5 out of 5 stars
By Rabbitmom on May 16, 2023

very helpful for dog stress

we are currently using this for a new dog who has fear aggression in order to be able to train her. but some people use it for fear of fireworks etc, it takes a few weeks to kick in, so start ahead of time.

Rated 1 out of 5 stars
By Meg on Apr 23, 2023
Top 1000 Contibutor

Didn’t Make A Difference

My Standard Poodle has struggled with anxiety. His veterinarian recommended that we try Zylkene before a prescription, but it didn’t help him at all. I didn’t see any differences in behavior or anxiety.

Rated 2 out of 5 stars
By Leah on Nov 21, 2022

Caution with dairy or beef sensitivities!

My dog has a whole host of food sensitivities after surviving parvovirus. Since beginning this supplement, his itching has dramatically increased and as a result he seems more anxious and uncomfortable. I wish this caution had been provided in the product information before spending $75. An expensive experiment!

Rated 3 out of 5 stars
By Emily on Nov 13, 2022

doesn’t work on everyone

Unfortunately I have a year old puppy lab/boxer mix and it does not work on him. I got it for him so that someone would be able to cut his nails and it has no effect on him :( but again it works on some and doesn’t on others!

Rated 5 out of 5 stars
By U593562 on Nov 19, 2022

House with 4 Doggy Babies

Best stuff the vet ever recommended to our family. Make sure you give the right dose, but product works great especially for traveling.

Rated 5 out of 5 stars
By Judy on Oct 27, 2022

Excellent Supplement for Separation Anxiety

As my pet became older she became more anxious when we left her at home alone. This supplement is amazing and calms her down within 15 minutes after injection.

Rated 5 out of 5 stars
By Pams on Jun 16, 2022

super fast!!

We have been using this pills for almost a month, I am not able yet to see changes but my vet told me that it takes at least a month to see results. However, this product arrived so fast, I was looking into other websites and most had a delivered time of almost 15 days. With Chewy we received the pills in two business days!!

Rated 5 out of 5 stars
By Rick on May 11, 2022

Not a miracle, but very helpful

We have a rescue dog that's about 13, we had him for almost 12 years. No one at the shelter told us we were his 5th family! He was borderline vicious... After a LOT of work and age, he's great. All said, we moved once after we got him, he freaked... We moved 6 weeks ago, across country. Vet gave us anxiety meds, helped some, he hated them, and he was a vegetable. I tried these, and within an hour he was very calm. I only give at night now. We did have an issue two nights ago, but he just went into another room to freak out and fell asleep. If he stays in our room, he gets a pill. Not his favorite. I will buy again, if he hasn't adjusted by then. It's a good product.

Rated 1 out of 5 stars
By Marty on Nov 10, 2022

Zylkene rating

This did not affect my hyper German Shepherd at all.

Rated 5 out of 5 stars
By Joseph on Mar 22, 2022

Works wonders for my dog!

Zylkene has helped my 2 year old dog adapt to a move to a new apartment/neighborhood great. Our vet had recommended it in the past but we never tried it, but after moving our dog was almost refusing to go outside (he's generally afraid of busy city traffic, and the new environment didn't help). I got him Zylkene (which arrived next day-thanks Chewy!), we used it for about a week, and it worked miracles. He would walk alongside busy roads just fine without being afraid like in the past, and now he feels confident and excited when exploring his new neighborhood. The best part is that when he takes it he is still his same playful, energetic self and it doesn't seem to have any adverse side effects. Highly recommend trying this for anyone dealing with an anxious pup and/or stressful situations. It may not work for all dogs but I'm glad we tried it and it helped ours.