Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone

By Zymox
Rated 4.8562 out of 5 stars
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$55.79Chewy Price
$73.99Chewy Price
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About This Item

  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.
Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsActive Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Natural Enzymes, Lysozyme, Lactoferrin, Lactoperoxidase.Active Ingredient: Hydrocortisone 1.0%., Inactive Ingredients: Benzyl Alcohol, Bet-Glucanase...Benzyl Alcohol, Beta-Glucanase, Cellulase...
Health FeatureEar CareEar CareEar CareEar CareEar Care
Breed SizeSmall Breeds, Medium Breeds, Large Breeds

Questions & Answers

56 Customer Questions

Is this safe for cats as well ?
Answer by SuzannaMay 14, 2021

Will the 1.25 ounce bottle be enough to treat 1 dog, both ears?
Answer by ChewyOct 08, 2017
The 1.25 ounce bottle will provide more than 2 weeks worth of daily maintenance to both ears.

how long do you massage the base of your pet's ear and keep the liquid in the ear canal?
Answer by ChewyAug 24, 2018
Massage the base of your pet's ear until the treatment has coated the infected area.

Is this safe if ingested? I have three dogs that like to lick/clean each others ears and want to ensure this is safe.
Answer by ChewyOct 02, 2018
Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use.

ReviewsWrite a Review

Rated 4.8562 out of 5 stars
2253 Reviews
Would recommend to a friend

2253 Customer Reviews

Rated 5 out of 5 stars
By geekycat1 on Nov 4, 2022

had no hope until I got this

I was extremely skeptical about this purchase but my cat had an ear infection for a year and it stunk the guck in his ear was absolutely disgusting I wanted to take him to the vet but it was 200 something dollars just to look at him I did a little Google research and this product came up it stated within seven days it would clear it up and OMG honestly it cleared it up within four days but I continue using it for the amount of time as instructed to be on the safe side. My cats attitude has completely changed he has so much pep in the step now this definitely works

Rated 5 out of 5 stars
By MoeJoe1 on Oct 25, 2022

highly recommend

MoeJoe (yes he lives up to his name lol) has had problems with his ears He is a gorgeous Black Lab who has medical problems (heart guard heart worms gave him seizures) food allergies and Blastoma of his back paw and he is great except his ears, we have had multiple trips to vet Dr Grant is a great doc but couldn’t explain the constant ear problems I cleaned them weekly and he did good but ear infection almost constantly we tried multiple antibiotic meds yes cleared it up only to have problems a week later and meds didn’t Agree with him and we tried Zymox what a relief for MoeJoe it worked like a charm I will constantly buy this for him to see his large goofy smile Thanks Zymox No script needed which is a blessing although 55.00 for 4 oz is a lot of money… I Highly recommend!!! Thanks from MoeJoe!!

Rated 5 out of 5 stars
By Beffers on Nov 28, 2022

works fast

My vet told me to get this for my dogs itchy ears and it worked within 2 days all his symptoms went away. He had some brown smelly stuff in his ears that is gone as well. I highly recommend this for your dogs ears you can even use as a preventative for ear infections. Thank you chewy for fast delivery.

Rated 5 out of 5 stars
By Melli on Nov 13, 2022


My dog was having a lot of issues with yeast in her ears. She went to the vet, i cleaned her ears every day and they just would not get better. Just twice using this and her ears are completely cleared up and no infection ever since!!!! This stuff is truly amazing!!!!!!! Highly recommend!!!

Rated 5 out of 5 stars
By JanisK on Nov 5, 2022

Works really well

My dog was always getting ear mites and I had a hard time treating it. My friend told me about this stuff so I tried it. It was a blessing because it took care of the mites and in 7 days he was back to himself. For prevention I use once a week now and it really works.

Rated 5 out of 5 stars
By Spacemite on Nov 2, 2022

Saved me alot of money

This product works as advertised took about a week and cleared my dogs ears out they were so bad he kept scratching i was dreading a vet visit so i figured id try it my self worked beautifully and saved me a vet trip!

Rated 5 out of 5 stars
By Valerie on Oct 16, 2022


Honestly I have a beagle his ears were looking really dirty possibly an infection I didnt want to take him to the vet since its so pricey I decided to try this thanks to all the great reviews and it worked!! With just one application his ear was clean I was so impressed!!

Rated 5 out of 5 stars
By Cindy on Nov 29, 2022

Quickly made a difference

I had two dogs with ear infections at the same time. Within a day the infections were significantly better. By the second day they were almost cleared up.

Rated 5 out of 5 stars
By Spook on Nov 11, 2022

Ear ointment

The dog ear ointment worked great. After a couple of days my dog stopped scratching around her ears. Saved me a trip to the vet. I recommend this product highly.

Rated 5 out of 5 stars
By Bhardesty on Sep 22, 2022

Amazing product!!!

My poor dog had an infection of some sort, shaking his head and yelping when we touched his ears and they smelled horrible, found this on chewy and read the reviews and just like the reviews said about a week into use the smell was gone and we were able to touch his ears no issues!!!