Zymox Topical Dog & Cat Enzymatic Skin Cream, 1-oz tube
By Zymox
$11.79Chewy Price
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$15.99Chewy Price
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About ZYMOX Enzymes for Healthy Ears and Skin


Antimicrobial and Antifungal Care
ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).
Committed to Healthy Ears, Skin and Coat, and Smiles
To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions
Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions
Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health
Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.
100% Safe, Gentle and Easy
Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!


Enzyme-Based and Antibiotic-Free
Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.
About ZYMOX
Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.
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19 Customer Questions
My dog has folliculitis on her chin. Is this safe to use this close to her mouth? She could obviously not lick it but still want to make sure we buy something safe..
Answer by • Feb 07, 2018
Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use. This product is for external use only. It's safe for use around the mouth but avoid contact with eyes. Stop use and consult veterinarian if condition gets worse or a rash or other allergic reaction develops.
My cat is severely allergic to fleas and has lost most fur on her rear area due to over grooming from the itching. Would this help her?
Answer by • Apr 06, 2018
We encourage speaking with your Veterinarian before combining supplements, for the safest opinion.
Can this be used in a dogs ears for yeast infection?
Answer by • Dec 22, 2017
The Enzymatic Skin Cream isn't recommended to use in the ears, you would want to use the Zymox Otic.
Can this be used in or on cats ears?
Answer by • Jul 01, 2021
It is recommended to avoid contact with eyes or mucous membranes. Do not apply to large areas of the body. We recommend speaking to your vet to see if this would be suitable for your pet's current treatment plan.