Anipryl (Selegiline HCl) Tablets for Dogs, 30 tablets, 15-mg

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$117.38 Autoship Price
(-5%)
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$123.56 Chewy Price
($4.12 /ea)
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Medications ship separately. Delivery times may vary.

About This Item

Details

Anipryl is an oral tablet prescribed by veterinarians to control the clinical signs associated with canine Cognitive Dysfunction syndrome (CDS) and uncomplicated canine pituitary-dependent hyperadrenocorticism (PDH). Hyperadrenocorticism (HAC) is also known as Cushing’s disease. This medication is an irreversible inhibitor of monoamine oxidase (MAOI). Specifically, it is a selective monoamine oxidase-B inhibitor (MAO-B), which could enhance catecholamine neuroactivity and increase dopamine levels in dogs. No specific laboratory tests are required for Anipryl treatment, and it can be given with your canine companion’s favorite food.

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4.2
Rated 4.2 out of 5 stars
99 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

77% Positive

Effectiveness

77% Positive

Ingredients

70% Positive

Long-Term Benefits

83% Positive

53 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Dolores on Sep 28, 2025

Scout's Meds

Chewy is the best for ordering prescriptions items. Orders arrive quickly and accurately. Support staff is always professional, friendly, and knowledgeable. My place

Chewy is the best for ordering prescriptions items. Orders arrive quickly and accurately. Support staff is always professional, friendly, and knowledgeable. My place forever for pet meds.

Rated 5 out of 5 stars
By Leona on Sep 8, 2025

It helped him be more normal

Harley was showing moderate dementia and it was scary. Our vet recommended anipryl for it. He was acting way better but not quite normal but so much better than

Harley was showing moderate dementia and it was scary. Our vet recommended anipryl for it. He was acting way better but not quite normal but so much better than before.

Rated 5 out of 5 stars
By Krystina on Jun 30, 2025

Works wonders!

Our 13 year old, Luna has been on this med for just over a year. Our vet recommended it due to her sundowner condition (pacing, whining, confusion and not sleeping

Our 13 year old, Luna has been on this med for just over a year. Our vet recommended it due to her sundowner condition (pacing, whining, confusion and not sleeping at night) it’s done wonders for her! She’s just about back to old self again! Very satisfied with this medication and with chewy delivery!

Rated 1 out of 5 stars
By Ann on Sep 12, 2025

Not a good medicine for my dog.

My dog did not tolerate the medicine. He stopped eating completely. He vomited daily & had diarrhea.

My dog did not tolerate the medicine. He stopped eating completely. He vomited daily & had diarrhea.

Rated 5 out of 5 stars
By Elizabeth on Apr 1, 2025

Saved a lot money on this Rx

Unfortunately, my 15 year old Miniature Schnauzer, Greta, has succumbed to the dreaded Canine Cognitive Decline (CCD). My Vet recommended Anipryl as it seems to

Unfortunately, my 15 year old Miniature Schnauzer, Greta, has succumbed to the dreaded Canine Cognitive Decline (CCD). My Vet recommended Anipryl as it seems to be the only treatment for this disorder. Ordering it from Chewy saved me quite a bit of money which is helpful since she may be on this medication for the remainder of her life. There is no cure for CCD but this medication seems to help some. I appreciate Chewy contacting my Vet to secure the prescription so that it can be mailed to me each month. I hope it will be for many months but this is uncertain. I love my Greta so much and want to do whatever I can to make her remaining years as comfortable as possible.

Rated 5 out of 5 stars
By Peter on Sep 21, 2025

The script arrived on schedule....no issues....thank you

This medication is needed for our "doggie dementia" pep ......

This medication is needed for our "doggie dementia" pep ......

Rated 5 out of 5 stars
By Liza on Sep 13, 2025

Seems to be alleviating anxiety

Relieves anxiety brought on by dementia

Relieves anxiety brought on by dementia

Rated 1 out of 5 stars
By Katherine on Jul 18, 2025

Dog Couldn't Stomach

Made my dog vomit after taking it.

Made my dog vomit after taking it.

Rated 1 out of 5 stars
By Pam on Dec 15, 2024

Poor delivery

It seems that the delivery service Chevy uses think it is ok for their drivers to throw the delivery from midway up to the porch. This is the third time my dog medicine

It seems that the delivery service Chevy uses think it is ok for their drivers to throw the delivery from midway up to the porch. This is the third time my dog medicine has been thrown onto the porch. If I could get the right dosage from another site I would.

Rated 3 out of 5 stars
By Cassandra on Sep 15, 2024

Anxiety inducing

We noticed cognitive decline in our 15 year old shiba. He would forget how to use his doggie door and get stuck in corners and be up all night pacing. Our vet prescribed

We noticed cognitive decline in our 15 year old shiba. He would forget how to use his doggie door and get stuck in corners and be up all night pacing. Our vet prescribed this med and his cognition improved for a couple months as far as remembering how to get outside and normalized his wake and sleep cycles but noticed he would be up pacing in circles all day after giving the med in the morning. Because this med affects his serotonin levels we could not give anti anxiety meds like alprazolam or trazadone. We have chosen to take him off the med due to the constant pacing and drooling. It is as like doggie crack. It took about 4 weeks for us to notice some improvement but then the side effects outweighed the benefits. He was on it for a total of 12 weeks.