Anipryl (Selegiline HCl) Tablets for Dogs, slide 1 of 1

Anipryl (Selegiline HCl) Tablets for Dogs

Prescription Item

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Strength: 15-mg
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Count: 30 tablets

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Description

Anipryl is an oral tablet prescribed by veterinarians to control the clinical signs of canine cognitive dysfunction syndrome (CDS) and of uncomplicated pituitary-dependent Addison's Disease (PDH). Since this medication is a selective monoamine oxidase -B inhibitor, it may enhance catecholamine neuroactivity and increase dopamine levels in dogs. Unlike other prescription medications, Anipryl does not require laboratory tests for treatment and it can be given with your canine companion’s favorite food.

Uses

Anipryl tablets are indicated for the control of clinical signs associated with canine cognitive dysfunction syndrome (CDS) and control of clinical signs associated with uncomplicated canine pituitary-dependent hyperadrenocorticism (PDH).

Possible Side Effects

Contact your veterinarian if your dog experiences restlessness/agitation, vomiting, disorientation, diarrhea, diminished hearing, possible drug interaction (weakness, confusion, incoordination and “seizure like” activity while being treated concurrently with metronidazole, prednisone, and trimethoprim sulfa), increase in destructive behavior in a dog with separation anxiety, anorexia, anemia, stiffness and polydipsia.

Drug & Food Interactions

Concurrent use of Anipryl with ephedrine or potential MAO inhibitors, such as amitraz, is not recommended.

Precautions

Anipryl is not recommended for other behavior problems such as aggression. The safety and efficacy of Anipryl has not been evaluated in dogs with debilitating systemic diseases other than PDH.

  1. Prescribing Information

See all items by Anipryl

  • Item Number
    146189
  • Common Brand Name(s)
    Anipryl, l-deprenyl, Eldepryl, Selegiline
  • Generic Name
    Selegiline Hydrochloride, L-Deprenyl Hydrochloride
  • For Use With
    Dogs
  • Administration Form
    Oral
  • Brand
    Zoetis
  • Product Form
    Tablet
  • Health Condition
    Senility, Cushing's Disease
  • Drug Type
    Inhibitor/Blocker
Ingredients
Ingredients

Selegiline Hydrochloride, L-Deprenyl Hydrochloride.

Instructions
Recommended Dosage

For pets with Cognitive Dysfunction Syndrome, orally administer 0.5-1.0 mg/kg once daily, preferably in the morning. For pets with Pituitary-Dependent Cushing's Disease, orally administer 1 mg/kg once daily, preferably in the morning.

Storage Instructions

Store at controlled room temperatures 68° - 77°F.

FAQ

What is Anipryl?

Anipryl is a type of oral medication called a monoamine oxidase inhibitor (MAOI). It is used in order to manage symptoms associated with senility (Canine Cognitive Dysfunction Syndrome). It is also prescribed to treat Cushing's disease in dogs when the cause is a pituitary tumor.

What are the benefits of Anipryl?

  • Only medication that is FDA approved for canine senility.
  • Is highly successful after several weeks of treatment.
  • Also helps to manage pituitary-dependent Cushings disease.

How is this medication given?

Always follow the prescribed directions given by your veterinarian. Anipryl is generally given by mouth once a day in the morning.

If you do not understand the directions your veterinarian gives you regarding the use of this medication, call him/her for further clarification.

How does this medication work?

Anipryl causes a rise in dopamine levels in the brain. This can help to improve cognitive processes in the brain.

What results can I expect?

You should start to notice an improvement in your pets senility symptoms. Results can vary from pet to pet and it may take several weeks to notice an improvement.

It can also take four to eight weeks to notice a chance in your pet when treating pituitary-dependent Cushings disease. If results are not observed within this time period, contact your veterinarian for re-evaluation.

Rating: 4.4 of 5 stars 16 Reviews 16 Reviews 4.4 out of 5 Stars

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Rating: 4.4 of 5 stars 4.4 / 5

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16 Reviews

Showing 1-10 of 16 Reviews

  • 5 out of 5 stars

    Don’t panic and give it a few days

    By on

    Our 16 year old Aussie developed cataracts late in life and we opted to not treat given the low likelihood of a positive outcome. So he is essentially blind. I attributed some of his worsening behavior like spinning in a circle to his loss of sight. My wife theorized that it was actually doggie dementia. After consulting our vet we put our guy on anipryl. The first night was terrifying. He seemed to get a lot worse. And he became weak. The next day we reduced the dose and it seemed to stop the new issues but didn’t seem to help with the symptoms we put him on the med for in the first place. We decided that since the med keeps dopamine in his system longer he is probably feeling pretty good even Our 16 year old Aussie developed cataracts late in life and we opted to not treat given the low likelihood of a positive outcome. So he is essentially blind. I attributed some of his worsening behavior like spinning in a circle to his loss of sight. My wife theorized that it was actually doggie dementia. After consulting our vet we put our guy on anipryl. The first night was terrifying. He seemed to get a lot worse. And he became weak. The next day we reduced the dose and it seemed to stop the new issues but didn’t seem to help with the symptoms we put him on the med for in the first place. We decided that since the med keeps dopamine in his system longer he is probably feeling pretty good even if physically he was struggling. And if this was all that’s left for him we were going to have to make the hard loving choice so what did we have to lose. So we returned the recommended higher dose, toughed it out with our boy and by day 4 the miracle started. It’s day 8 on 8/3/2020 and it looks like our boy has gone back in time 6-8 months. We couldn’t be happier and are eager to see what he is like after the 4 weeks the manufacturer cites in their literature about the product. I hope you all have the same great experience. Good luck. … more

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  • 5 out of 5 stars

    Gave me most of my dog back

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    My 16-yr-old doxie made a noticeable change after a just few days on this medication! She had retreated into herself, got stuck in corners having lost her ability to back up, and was anxious. I had first had her on an anti-anxiety medication but it all it did was dull her. Now she's back to seeking me out (altho I don't think she really knows who I am anymore), wags her tail even sometimes; just seems so much Happier. She's better at getting herself out of jams by herself (getting stuck staring in corners, etc.) now too. Thank you, Anipryl.

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  • 5 out of 5 stars

    It really works!

    By on

    My 14.5 yr old Belgian Malinois has been on Anipryl approximately 1 month. I cannot believe the change in her behavior. She used to be very restless, had major anxiety, and acted like she heard things that weren't there. It was so very sad to watch her feel this way. After about 2 wks, we were able to take her off trazadone. And now she is just on Anipryl. I am so happy that she is no longer anxious, and no longer "hears things". She's completely changed and I couldn't be happier!

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  • 5 out of 5 stars

    Amazing! Its working for our dog.

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    Our 14 year old, 3 pound Yorkie has been taking Anipryl for less then a week, and we’ve noticed a huge change. No more hiding in the closet shaking, and no more or crying and starting at the walls. His appetite’s been good and no side effects from medicine. So far, so good. I hope it continues to work.

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  • 3 out of 5 stars

    Too Early to Tell

    By on

    Our 18 year old dog has been on Anipryl for just over 2 weeks. We have seen some improvement in his behavior (i.e, he has more energy during the day, wants to go on more walks, etc). But some of the more disturbing dementia symptoms (i.e. crying, staring at walls, restlessness, etc) are still occurring. We are going to keep him on Anipryl for another month to see if there is an improvement.

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  • 5 out of 5 stars

    AMAZING! IT WORKS!

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    This pill gave me my dog back. Oliver is a 15 year old Yorkie; he will be 16 in November. He had become very aggressive & had bit me several times, which was not like his usual sweet self. He was confused & seemed very scared & disoriented. This medicine brought him back to his original self. Now, it took about 2 - 3 weeks to see the change, so be patient. I’m so grateful now & it’s truly like a miracle!

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  • 5 out of 5 stars

    I was a skeptic...

    By on

    Now I'm convinced. We tried to address some of her symptoms with other changes, thinking she might just have arthritis pain and other issues that would make her uncomfortable, since she's 13 yrs old. This medication had an immediate effect on my old girl, who has had increasing Cushing's symptoms: panting, pacing, extreme reaction to thunder (she never had that when she was young) and just generally looking miserable. I am astounded at how much more energy she has, and how she moves and just generally looks happier and more peaceful. Wow. Really amazing.

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  • 5 out of 5 stars

    Can't believe it- it works!

    By on

    My little 14 year old dachsie began suffering symptoms of cognitive dementia--she would have trembling spells, act like she was seeing things, etc. I did a TON of research and eventually started her on Anipryl, Tumeric Bites, Fish Oil, Senilife, Co Q 10, and extra virgin coconut oil (has MUFA's which feed the brain). It took about 3 weeks, but WOW- huge difference and I've been on this protocol with her about 4 months and it just keeps working. The symptoms are almost non existent--instead of daily, she may have a trembling spell once per month. I know cognitive dementia is progressive so don't know how long this can hold off the inevitable but I was worried I was going to lose her and we've My little 14 year old dachsie began suffering symptoms of cognitive dementia--she would have trembling spells, act like she was seeing things, etc. I did a TON of research and eventually started her on Anipryl, Tumeric Bites, Fish Oil, Senilife, Co Q 10, and extra virgin coconut oil (has MUFA's which feed the brain). It took about 3 weeks, but WOW- huge difference and I've been on this protocol with her about 4 months and it just keeps working. The symptoms are almost non existent--instead of daily, she may have a trembling spell once per month. I know cognitive dementia is progressive so don't know how long this can hold off the inevitable but I was worried I was going to lose her and we've had many months of much better quality of life due to this product and my overall protocol noted above. I hope this works as well for your fur baby. I was thrilled with this product--give it a few weeks to kick in per what the research says and my experience too. … more

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  • 1 out of 5 stars

    My dog had side effects

    By on

    My sweet Lily had diarrhea and anxiety attacks. She is off it now and may continue with a lower dose

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  • 4 out of 5 stars

    It's helping

    By on

    I have a 13-15 yr old Australian cattle dog. She was exhibiting Sundowners and she is blind due to glaucoma( eyes removed) and was getting lost in our home after 8 yrs with us. The Sundowners symptoms are greatly reduced now. She is still"lost" somewhat in our house, and outside but I'd say her cognitive decline is improved or at least, stalled.

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