Anipryl (Selegiline HCl) Tablets for Dogs, slide 1 of 1

Anipryl (Selegiline HCl) Tablets for Dogs

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Strength: 30-mg
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Count: 30 tablets

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Anipryl is an oral tablet prescribed by veterinarians to control the clinical signs of canine cognitive dysfunction syndrome (CDS) and of uncomplicated pituitary-dependent Addison's Disease (PDH). Since this medication is a selective monoamine oxidase -B inhibitor, it may enhance catecholamine neuroactivity and increase dopamine levels in dogs. Unlike other prescription medications, Anipryl does not require laboratory tests for treatment and it can be given with your canine companion’s favorite food.

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Anipryl tablets are indicated for the control of clinical signs associated with canine cognitive dysfunction syndrome (CDS) and control of clinical signs associated with uncomplicated canine pituitary-dependent hyperadrenocorticism (PDH).

Possible Side Effects

Contact your veterinarian if your dog experiences restlessness/agitation, vomiting, disorientation, diarrhea, diminished hearing, possible drug interaction (weakness, confusion, incoordination and “seizure like” activity while being treated concurrently with metronidazole, prednisone, and trimethoprim sulfa), increase in destructive behavior in a dog with separation anxiety, anorexia, anemia, stiffness and polydipsia.

Drug & Food Interactions

Concurrent use of Anipryl with ephedrine or potential MAO inhibitors, such as amitraz, is not recommended.


Anipryl is not recommended for other behavior problems such as aggression. The safety and efficacy of Anipryl has not been evaluated in dogs with debilitating systemic diseases other than PDH.

Please note product may arrive in a Chewy Pharmacy vial, manufacturer packaging is shown for reference.

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  1. Prescribing Information

See all items by Anipryl

  • Item Number
  • Common Brand Name(s)
    Anipryl, l-deprenyl, Eldepryl, Selegiline
  • Generic Name
    Selegiline Hydrochloride, L-Deprenyl Hydrochloride
  • For Use With
  • Administration Form
  • Product Form
  • Health Condition
    Senility, Cushing's Disease
  • Drug Type

Selegiline Hydrochloride, L-Deprenyl Hydrochloride.

Recommended Dosage

For pets with Cognitive Dysfunction Syndrome, orally administer 0.5-1.0 mg/kg once daily, preferably in the morning. For pets with Pituitary-Dependent Cushing's Disease, orally administer 1 mg/kg once daily, preferably in the morning.

Storage Instructions

Store at controlled room temperatures 68° - 77°F.


What is Anipryl?

Anipryl is a type of oral medication called a monoamine oxidase inhibitor (MAOI). It is used in order to manage symptoms associated with senility (Canine Cognitive Dysfunction Syndrome). It is also prescribed to treat Cushing's disease in dogs when the cause is a pituitary tumor.

What are the benefits of Anipryl?

  • Only medication that is FDA approved for canine senility.
  • Is highly successful after several weeks of treatment.
  • Also helps to manage pituitary-dependent Cushings disease.

How is this medication given?

Always follow the prescribed directions given by your veterinarian. Anipryl is generally given by mouth once a day in the morning.

If you do not understand the directions your veterinarian gives you regarding the use of this medication, call him/her for further clarification.

How does this medication work?

Anipryl causes a rise in dopamine levels in the brain. This can help to improve cognitive processes in the brain.

What results can I expect?

You should start to notice an improvement in your pets senility symptoms. Results can vary from pet to pet and it may take several weeks to notice an improvement.

It can also take four to eight weeks to notice a chance in your pet when treating pituitary-dependent Cushings disease. If results are not observed within this time period, contact your veterinarian for re-evaluation.

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