Cyclavance (cyclosporine modified oral solution) for Dogs, 100-mg/mL, 50-mL

CYCLAVANCE is an oral solution of cyclosporine that lowers the immune response. CYCLAVANCE selectively acts on the immune cells involved in the allergic reaction. CYCLAVANCE reduces the inflammation and itching associated with atopic dermatitis.

CYCLAVANCE should be given daily until improvement is seen. This will generally be the case within 30 days. You should contact your veterinarian if you are not satisfied with your dog’s response. Once the signs of atopic dermatitis are satisfactorily controlled, your veterinarian may reduce the frequency of administration of the product. Dose adjustment should only be carried out in consultation with your veterinarian. Your veterinarian will perform a clinical assessment at regular intervals and adjust the frequency of administration up or down according to the clinical response obtained.

Your dog should not be given CYCLAVANCE if s/he: * Has a history of cancer or may possibly have cancer. * Has a history of seizures, diabetes mellitus, and infections. * Is hypersensitive to cyclosporine.

Tell your veterinarian about: * Any digestive upset (vomiting or diarrhea) your dog has had * Any history of lack of appetite and/or weight loss your dog has had * Any serious disease or health conditions your dog has had * Any allergies that your dog has now or has had * Any medications (specifically any azoles (e.g. ketoconazole and/or steroids) that you are giving your dog or plan to give your dog, including those you can get without prescription (over the counter) and any dietary supplements * If you plan to breed your dog, or if your dog is pregnant or nursing

Talk to your veterinarian about: * What tests might be done before CYCLAVANCE is prescribed * The potential side effects your dog may experience while taking CYCLAVANCE * How often your dog may need to be examined by your veterinarian * The risks and benefits of using CYCLAVANCE