Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Infection Solution, 1.25-fl oz bottle

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About This Item

Details

  • Naturally occurring enzymes are highly effective against bacterial, fungal and yeast ear infections, plus the anti-inflammatory power of hydrocortisone. While this formula isn’t designed to treat dog and cat ear mites, it could help relieve symptoms and protect against secondary infections from yeast, bacteria, and fungus.
  • Proven antimicrobial LP3 Enzyme System inhibits, splits and destroys the offending organisms while leaving healthy cells alone.
  • Four additional biofilm-reducing enzymes destroy the hard-to-penetrate biofilm slime layer that obscures the microbe.
  • Ideal for cases of repeated infections or infections that won’t resolve, and bacteria will never develop a resistance to the enzymes. Great alternative to antibiotics and the non-toxic solution won’t irritate a pet’s sensitive or irritated skin and is great for dogs and cats.
  • Made in the USA.

Ingredients

Instructions

Learn More About Zymox From Our Team of Experts

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Questions & Answers

30 Customer Questions

Can I give this to my dog while he takes amoxicillin?

Answer by DrMoore • Dec 16, 2025
Yes. It is safe.

What does “apply liberally” mean exactly ? I.e., how many drops of the solution should I use daily for a large dog ( standard poodle)?

Answer by Chewy • Mar 26, 2020
It is directed to apply a generously amount of solution to un-cleaned ear, filling ear canal.

Is it safe if ingested Some cats lick their paws and pass it by the ear area ear after using these drops

Answer by Chewy • Oct 30, 2019
This solution is safe if accidentally ingested.

I cleaned my dogs ears today. How long should I wait to use this?

Answer by Chewy • Jan 17, 2018
You should not clean the ears before or during use. Doing so will disrupt the enzyme system. You can wait 5 days before administering this solution.
Reviews
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4.8
Rated 4.8 out of 5 stars
2314 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

86% Positive

Ease of Use

94% Positive

Effectiveness

93% Positive

Safety

90% Positive

1181 Customer Reviews

Rated 1 out of 5 stars
By Courtney on Jan 24, 2026

Everything they claim is false

I bought this because their description of this medication stated that the ear drops help getting rid of any bacterial or fungal infections. My cat had a really

I bought this because their description of this medication stated that the ear drops help getting rid of any bacterial or fungal infections. My cat had a really bad ear and I was in search of medicine to ais getting rid of it. I was desperate bc my vet would not see my cat without payment. All this description of this medicine led me to believe that it will get rid of a ear infection. Let's just say the ingredients are no different than the 15 dollar ear care cleaning swabs. The difference I was lead to believe with this product would kill bacterial and fungal infections. It does not. It only lessens the irritation part of ear infection. Don't trust their description. And I also thought I was getting the sale price, only to get my bank statement and it was the full amount. Never would I pay 40 bucks for mainly hydrocortisone. I'm definitely going to be asking for my money back!!

Rated 5 out of 5 stars
By Madeline on Jan 13, 2026

Fixed ear infection within 24 hours.

This is amazing. Like actually incredible. I got home from a trip and my golden had the worst ear infection ive ever seen. Shaking her head, black wax EVERYWHERE

This is amazing. Like actually incredible. I got home from a trip and my golden had the worst ear infection ive ever seen. Shaking her head, black wax EVERYWHERE. I mean everywhere, there was a shred of skin uncovered in her ear. Absolutely besides herself crying when you pet her ear even lightly. Of course I was livid at our sitter. This was a saturday night, vets closed til monday. I bought this in the meantime along with regular ear cleaner, it got here monday morning, vet was scheduled for tuesday. Come tuesday they were so impressed. She doesnt even need extra medication from them. Absolutely grateful. The price is super high but its worth it.

Rated 4 out of 5 stars
By Mary on Jan 28, 2026

Effective

I had been trying to keep my dog's ear clean for about a month, but the dark brown ear wax kept returning. She also kept scratching at it. I decided to try this

I had been trying to keep my dog's ear clean for about a month, but the dark brown ear wax kept returning. She also kept scratching at it. I decided to try this Zymox solution and followed the directions to a 't,' and it worked wonderfully-the brown ear wax is gone and she doesn't scratch. We live in the boondocks, so this saved me a trip to the vet and a vet bill.

Rated 5 out of 5 stars
By Victoria on Dec 6, 2025
Top 500 Contributor

Once I get it into my dog's ear, it seems to help quickly.

My dog has itchy ears and even some scabbing from itching. I've used this after wiping her ear with the medicated pads. She absolutely hates it, i am pretty good

My dog has itchy ears and even some scabbing from itching. I've used this after wiping her ear with the medicated pads. She absolutely hates it, i am pretty good with bribing her, but it's slow to drip out so I have a hard time moving quickly. I really wish there was another method to getting these drops in her ears. For some medications, i've used cotton balls, soak them in the medicine. Then, softly make my way around the ear canal while squeezing the cotton ball so it's not a hard drop, more of a gentle wet cloth. This stuff is too thick for a cotton ball to absorb, but it does appear to be effective with what little that my dog has allowed me to use (which is important because you only get 1 chance to aim correctly before she runs and shakes her head).

Rated 5 out of 5 stars
By Sarah on Dec 15, 2025

It worked! Less head shaking now

I put two drops in each ear for 7 days, and the brown/black gunk in my dog's ears has greatly decreased! I supplemented this with cleaning his ears a few times throughout

I put two drops in each ear for 7 days, and the brown/black gunk in my dog's ears has greatly decreased! I supplemented this with cleaning his ears a few times throughout the week as the drops loosened things up that were originally too deep to get. Money well spent - cheaper than seeing the vet and getting antibiotics, which I also didn't want to do anyways. So if you're hesitant to get expensive drops like I was, take the chance and do it!

Rated 5 out of 5 stars
By Bonnie on Nov 29, 2025

Quick and lasting results!

My beloved elderly rescued cat has allergies that contribute to frequent ear infections. She also has heart and immune-system problems, so stressing her out by

My beloved elderly rescued cat has allergies that contribute to frequent ear infections. She also has heart and immune-system problems, so stressing her out by taking her to the vet is always a risk and can make her health even worse. My last vet bill for an ear infection was approx. $500 and results didn't last. When I saw some dark brown gunk in her ears again, I tried Zymox Plus Otic and was amazed by the quick and lasting results. My cat and I are both so grateful for this product! An added bonus is that she doesn't mind the thicker consistency of this product compared to ear washes.

Rated 5 out of 5 stars
By Marilyn on Jan 29, 2026

Really help to relieve my dog’s persistent ear problems.

We had been fighting an ear infection for a while. It’s a chronic thing with him. After the normal meds we used in the past didn’t work we tried this. He is now

We had been fighting an ear infection for a while. It’s a chronic thing with him. After the normal meds we used in the past didn’t work we tried this. He is now doing well.

Rated 5 out of 5 stars
By Rick on Jan 5, 2026

Smell and dirt in ears of my Daschund

Applied for the full week and it seems to be working , her ear doesn’t smell so bad and the dirt has diminished, not sure if this is a permanent fix at this point

Applied for the full week and it seems to be working , her ear doesn’t smell so bad and the dirt has diminished, not sure if this is a permanent fix at this point but it was better than before I applied the Zymox

Rated 5 out of 5 stars
By Samanthy on Nov 2, 2025

Miracle Worker

Our sweet sweet orange boy is our medical mystery/ problem, this child has had a yeast infection in his left ear for 8+ months that we just COULD NOT get rid of,

Our sweet sweet orange boy is our medical mystery/ problem, this child has had a yeast infection in his left ear for 8+ months that we just COULD NOT get rid of, antibiotics in every form and of every strength, ear cleansers in all the different strengths, creams, ear wipes non medicated and medicated. We are already on a grain free yeast free food because of his stomach issues and his chicken allergy (don’t get me started on cat food that doesn't contain chicken) We’ve done EVERYTHING short of surgical options and even those were not a 100% fix for his problem. We’ve been using this product as it directs for 3 days and OH MY LANTA the DIFFERENCE it has made already, no more crust hanging from his ear, no more smell, no more crust flying in the air when his shakes his head, no more junk left on the bed from him cleaning his own ears, it’s so great! I’m what you could call a helicopter parent, an overly controlling one if you will; I’m extremely picky on what we use on them, around them, for them. We have Binks who is our medical mystery, we have Toby that has extremely sensitive skin along with his own medical problems and then we have 2 brand new Kits that I brought home as bottle babies, plus we’ve had a babe that had asthma and heart problems so for good reason it takes me a hot minute to make a decision that’s not suggested by our vet that I trust 100% so when I tell you I went on this ear cleaner hunt for near 3 weeks I’m not joking but my mom gut kept coming back to this product and I’m so glad it did, our boy no longer plays for 30 seconds and then has to itch or shake or nothing because his ear isn’t bothering him, it’s clearing up so well and I’m fully hoping that this is what knocks this infection OUT!( The photo attached was how his ear use to look; I know not a great photo but he hates his ears messed with )

Rated 5 out of 5 stars
By Tiffany on Nov 3, 2025

UNBELIEVABLE!!!!!!

My old cat Present has MANY health issues, and the answer ALWAYS seems to be antibiotics!! Her ears, have been bothering her like crazy, scratching all day and night,

My old cat Present has MANY health issues, and the answer ALWAYS seems to be antibiotics!! Her ears, have been bothering her like crazy, scratching all day and night, as well as sneezing, but that is just her, the ears is sort of new.. but 2 rounds of antibiotics helped for a week or so, then one day I noticed, she was so wobbly on her feet, wouldn't eat, I had to do something!!! I searched online and saw this, kept reading, so I ordered.. she HATES it but the very first day, I noticed she actually slept better!!! We are on day 4, and there is ZERO scratching!!!! It says use for 7 days, this is a miracle!!!!!