K9 Advantix II Flea & Tick Spot Treatment for Dogs, 21-55 lbs, 2 Doses (2-mos. supply)

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About This Item

Details

  • Helps to protect dogs weighing 21 to 55 pounds from fleas, ticks, mosquitoes, biting flies and lice.
  • Starts working within hours of application.
  • Kills and repels on contact, so fleas don’t have to bite your furbaby to die.
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours.
  • No prescription needed.

Ingredients

Instructions

Size

FAQ

Learn More About K9 Advantix II From Our Team of Experts

Questions & Answers

27 Customer Questions


How do you apply the topical treatment? Is it messy?

Answer by ChewyMar 21, 2024
To apply, remove applicator tube from the package. Use scissors and peel down foil. Hold applicator tube in an upright position and pull the cap off the tube. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. The dog should be standing for easy application. The entire contents of the K9 Advantix II tube should be applied evenly on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Discard the empty tube.

How long do I need to wait before I can cuddle and pet my dog after using K9 Advantix II? How long do I have to wait to bush him and is that fur toxic?

Answer by ChewyAug 21, 2019
Once the treatment has been absorbed by the dogs' coat and they're fully dry, normally between 1-5 hours depending on the environment, the treated area should be safe for anyone to touch. It's always recommended to wash your hands after touching your pet.

Does this Kill ticks on contact

Answer by ChewyDec 14, 2019
K9 Advantix II kills fleas within 12 hours. New fleas that jump on the dog from the surroundings, such as grass, carpet and pet bedding, are killed within 2 hours with protection against further infestation for at least 4 weeks.

I have a dog and two rats at home, can I use this on my dog even with the rats in the same home? I seen that it is dangerous for cats but not sure about other pets.

Answer by ChewyMay 29, 2018
K9 Advantix for Dogs (containing pymethrin), Advantage ll (containing pyriproxyfen) should not be used with or around rats due to increased toxicity.

4.5
Rated 4.5 out of 5 stars
4656 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

83% Positive

Ingredients

80% Positive

Long-Term Benefits

83% Positive

2163 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Denise on Jan 22, 2026

No more ticks

Our 8y.o. dog & 5 m.o. puppy were getting ticks daily during a warm spell in December. After one application the first week of January the ticks are a thing of

Our 8y.o. dog & 5 m.o. puppy were getting ticks daily during a warm spell in December. After one application the first week of January the ticks are a thing of the past! And our dog and pup have had no bad reaction to this product. I've used it for years on dogs and have never witnessed a bad reaction after using K-9 Advantix II. Also, we have never had a case of fleas. Our dogs enjoy running loose outside where there are plenty of wild critters such as squirrels, rabbits, deer. etc. So our dogs have plenty of ops for picking up fleas & ticks this product also claims to repel mosquitoes which carry heart worms. So glad to note our dogs have never had a case of heart worms . I recommend this product !


Rated 1 out of 5 stars
By Elonda on Feb 7, 2026

4 orders paid for separately all in 1 box!!!! Not happy

Box was too heavy and crushed smaller items..you packed 4 bags of litter , cat food, and dog food, 2 boxes of flea control, 2 bottles of eye wash, treats into 1

Box was too heavy and crushed smaller items..you packed 4 bags of litter , cat food, and dog food, 2 boxes of flea control, 2 bottles of eye wash, treats into 1 box..it was too heavy and crushed smaller items. Those 4 orders were ordered separately and paid for separately. Why did you consolidate 4 paid orders of sensitive items????


Rated 4 out of 5 stars
By Kathy on Feb 8, 2026

Flea & Tick Treatment

This treatment works great but if you live in the country, which is full pest of kinds a lot of treatment will not last long. This only last about 3 weeks and the

This treatment works great but if you live in the country, which is full pest of kinds a lot of treatment will not last long. This only last about 3 weeks and the fleas were on my dogs like crazy. This was for Latte & Mocha.


Rated 3 out of 5 stars
By Pat on Feb 5, 2026

It only last 2-3 weeks

The product’s good is effective against fleas unfortunately, it only lasts 2 to 3 weeks at the most. Auto shipping doesn’t work because you constantly run out of

The product’s good is effective against fleas unfortunately, it only lasts 2 to 3 weeks at the most. Auto shipping doesn’t work because you constantly run out of the product.


Rated 1 out of 5 stars
By Tim on Jan 4, 2026

Poorly packaged

All items were in a box with a 47# bag of dog food. The flaps were taped but not edges. The dog food squished other packaging. 2 of the Advantix boxes came open

All items were in a box with a 47# bag of dog food. The flaps were taped but not edges. The dog food squished other packaging. 2 of the Advantix boxes came open. 3 does fell out of the packing carton in gaps were the edges bulged.


Rated 5 out of 5 stars
By Kimberle on Dec 22, 2025

I buy this every year!

I have it on my calendar as a reminder to purchase enough for a year on Black Friday, I have three Aussie's and the savings and quality of this product helps me

I have it on my calendar as a reminder to purchase enough for a year on Black Friday, I have three Aussie's and the savings and quality of this product helps me be a better pet parent. We are "bug" free for another year. Thanks Chewy!


Rated 1 out of 5 stars
By Paul on Nov 30, 2025

Does not work very well!

My dog is still continuously scratching, I even applied a second dose after 3.5 weeks per advice from Elanco the manufacturer, and still the same results, still

My dog is still continuously scratching, I even applied a second dose after 3.5 weeks per advice from Elanco the manufacturer, and still the same results, still lots of fleas. I even have a pest control company that sprays my yard every two months! I would not recommend this product.


Rated 5 out of 5 stars
By MARYLEE on Dec 9, 2025

Effective Treatment

I have used it for each of my dogs for many years. I bought for Charlie and Stella most recently.Stella died so Charlie inherited her sippy of Advantix so I did

I have used it for each of my dogs for many years. I bought for Charlie and Stella most recently.Stella died so Charlie inherited her sippy of Advantix so I did cancel the recurring order as Charlie now works through Stella's 12 month supply.


Rated 2 out of 5 stars
By Allie on Jan 27, 2026

Didn't work

My sister and I bought this for the dogs in our houses. The fleas are exceptional this year. This treatment was not effective at all.

My sister and I bought this for the dogs in our houses. The fleas are exceptional this year. This treatment was not effective at all.


Rated 5 out of 5 stars
By Courtney on Jan 7, 2026

Works very well!

My poor girl had fleas and I had tried everything over the counter. This medicine without a prescription worked quickly and my fur baby has no more fleas!

My poor girl had fleas and I had tried everything over the counter. This medicine without a prescription worked quickly and my fur baby has no more fleas!